Integrated Health Sciences Facility Core

项目摘要--综合卫生科学设施核心(IHSFC) 综合健康科学设施核心(IHSFC)促进以人为中心的易感性研究， 毒性、疾病、临床治疗和精确的环境健康的途径，具有总体目标 加强中心调查人员的职业生涯，并将与农村暴露有关的新见解转化为 人口健康。要成功实现这一目标，需要一流的基础设施 满足研究人员设计和实施转化性研究的关键需求，同时确保 研究对象和调查人员、重复性和严谨的科学方法。与 社区参与核心，IHSFC提高环境健康素养和公共卫生实践 并促进与环境健康科学(EHS)相关的研究成果的双向翻译 从基础或临床研究到应用或公共卫生领域。《公约》的具体目标 IHSFC的目标是：1)为开展与EHS相关的临床和转化性研究提供基础设施； 包括a)提供资源，协助获得批准将人体受试者用于临床和 与EHS相关的翻译研究；b)招募人类受试者进行相关的临床和翻译研究 (C)评估和监测肺部和全身生理反应；d)评估和监测 量化肺损伤(呼吸道和实质)的放射表现和生理反应；e) 通过向所有成员提供生物统计支持，解决严密性和重现性问题；以及f)提供生态 环境卫生研究人员使用移动设备的瞬时评估和健康症状采样 设备。IHSFC将：目标2)确保进行与EHS相关的临床和翻译研究 安全，并保持主体机密性；目标3)发展社区之间的积极伙伴关系 影响临床和公共卫生研究的研究人员和社区组织 并支持社区参与联谊会；以及Aim 4)为早期- 对EHS感兴趣的阶段性调查人员。IHSFC协助招聘、评估和评估以下人员 研究对象和支持成像、心肺生理测试、生物采样和组织和 为实现这些目标而进行的生物武器采购。IHSFC提供研究设计和数据分析协助， 支持社区参与奖学金，并提供获得尖端技术的机会，以评估和 分析环境空气污染物对肺结构的影响。这项技术可以应用于小动物 如啮齿动物、大型动物如猪和人类，促进相关基本发现的翻译 暴露在环境中的人类。总体而言，IHSFC整合了促进临床和 EHSRC内的翻译研究。

PROJECT SUMMARY - INTEGRATED HEALTH SCIENCES FACILITY CORE (IHSFC) The Integrated Health Sciences Facility Core (IHSFC) promotes human-centered research on susceptibilities, pathways of toxicity, disease, clinical treatment, and precision environmental health, with the overarching goal to enhance the careers of Center investigators and translating new insights related to rural exposures to population health. Successful accomplishment of this goal requires a state-of-the-art infrastructure that addresses the critical need of investigators to design and implement translational research with safety to both research subjects and investigators, reproducibility, and rigorous scientific approaches. In conjunction with the Community Engagement Core, the IHSFC enhances environmental health literacy and public health practice and facilitates the translation of findings relevant to environmental health science (EHS) bi-directionally along the spectrum from basic or clinical research to the applied or public health arenas. The Specific Aims of the IHSFC are Aim 1) to provide the infrastructure to carry out clinical and translational studies relevant to EHS, including a) providing resources to assist in obtaining approval for the use of human subjects for clinical and translational studies relevant to EHS; b) recruiting human subjects for clinical and translational studies relevant to EHS; c) assessing and monitoring pulmonary and systemic physiologic responses; d) assessing and quantifying radiographic manifestations of lung injury (airway and parenchymal) and physiological responses; e) addressing rigor and reproducibility by providing biostatistical support to all member; and f) providing ecological momentary assessment and health-symptom sampling for environmental health researchers using mobile devices. The IHSFC will: Aim 2) ensure that clinical and translational studies relevant to EHS are carried out safely, and that subject confidentiality is maintained; Aim 3) develop engaged community partnerships between researchers and community-based organizations that impact the conduct of clinical and public health research and support the Community Engagement Fellowship; and Aim 4) provide the infrastructure for training of early- stage investigators with interest in EHS. The IHSFC facilitates the recruitment, evaluation, and assessment of research subjects and supports imaging, cardiopulmonary physiology testing, biologic sampling, and tissue and biospecimen procurement to attain these Aims. The IHSFC provides study design and data analysis assistance, supports a Community Engagement Fellowship, and offers access to cutting-edge technology to evaluate and analyze the effects of ambient air pollutants on lung structures. This technology can be applied to small animals such as rodents, large animals such as pigs, and humans, promoting the translation of basic discoveries related to environmental exposures to humans. Overall, the IHSFC integrates resources that facilitate clinical and translational research studies within the EHSRC.