Integrated Health Sciences Facility Core

综合健康科学设施核心

• 批准号: 10393902
• 负责人: ALEJANDRO Pierre COMELLAS
• 金额: $ 15.59万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10393902
• 关键词: Address; Air Pollutants; Animal Model; Animals; Area; Basic Science; Behavior; Biological; Biometry; Blood Vessels; Cardiopulmonary Physiology; Clinical; Clinical Investigator; Clinical Research; Clinical Research Associate; Clinical Treatment; Communities; Computers; Core Facility; Data Analyses; Disease; Doctor of Philosophy; Ecological momentary assessment; Ensure; Environment; Environmental Exposure; Environmental Health; Evaluation; Exposure to; Faculty; Family suidae; Fellowship; Goals; Health; Health Sciences; Human; Image; Infrastructure; Iowa; Lung; Monitor; National Institute of Environmental Health Sciences; Pathway interactions; Phenotype; Physiological; Population; Predisposition; Public Health; Public Health Practice; Pulmonary function tests; Pulmonology; Radiology Specialty; Reproducibility; Research; Research Design; Research Personnel; Research Subjects; Research Support; Resources; Respiratory Function Tests; Rodent; Rural; Safety; Sampling; Science; Scientist; Strategic Planning; Structure; Symptoms; Technology; Testing; Time; Tissues; Toxic effect; Training and Infrastructure; Translating; Translational Research; Translations; Universities; base; behavior influence; career; community engagement; community partnership; data to knowledge; design; experience; handheld mobile device; health literacy; health science research; human subject; imaging facilities; injured airway; insight; interdisciplinary collaboration; interest; lung injury; member; population health; professor; public health research; radiological imaging; recruit; research study; research vision; response; translational study

PROJECT SUMMARY - INTEGRATED HEALTH SCIENCES FACILITY CORE (IHSFC) The Integrated Health Sciences Facility Core (IHSFC) promotes human-centered research on susceptibilities, pathways of toxicity, disease, clinical treatment, and precision environmental health, with the overarching goal to enhance the careers of Center investigators and translating new insights related to rural exposures to population health. Successful accomplishment of this goal requires a state-of-the-art infrastructure that addresses the critical need of investigators to design and implement translational research with safety to both research subjects and investigators, reproducibility, and rigorous scientific approaches. In conjunction with the Community Engagement Core, the IHSFC enhances environmental health literacy and public health practice and facilitates the translation of findings relevant to environmental health science (EHS) bi-directionally along the spectrum from basic or clinical research to the applied or public health arenas. The Specific Aims of the IHSFC are Aim 1) to provide the infrastructure to carry out clinical and translational studies relevant to EHS, including a) providing resources to assist in obtaining approval for the use of human subjects for clinical and translational studies relevant to EHS; b) recruiting human subjects for clinical and translational studies relevant to EHS; c) assessing and monitoring pulmonary and systemic physiologic responses; d) assessing and quantifying radiographic manifestations of lung injury (airway and parenchymal) and physiological responses; e) addressing rigor and reproducibility by providing biostatistical support to all member; and f) providing ecological momentary assessment and health-symptom sampling for environmental health researchers using mobile devices. The IHSFC will: Aim 2) ensure that clinical and translational studies relevant to EHS are carried out safely, and that subject confidentiality is maintained; Aim 3) develop engaged community partnerships between researchers and community-based organizations that impact the conduct of clinical and public health research and support the Community Engagement Fellowship; and Aim 4) provide the infrastructure for training of early- stage investigators with interest in EHS. The IHSFC facilitates the recruitment, evaluation, and assessment of research subjects and supports imaging, cardiopulmonary physiology testing, biologic sampling, and tissue and biospecimen procurement to attain these Aims. The IHSFC provides study design and data analysis assistance, supports a Community Engagement Fellowship, and offers access to cutting-edge technology to evaluate and analyze the effects of ambient air pollutants on lung structures. This technology can be applied to small animals such as rodents, large animals such as pigs, and humans, promoting the translation of basic discoveries related to environmental exposures to humans. Overall, the IHSFC integrates resources that facilitate clinical and translational research studies within the EHSRC.

项目摘要-综合健康科学中心（IHSFC） 综合健康科学设施核心（IHSFC）促进以人为本的研究， 毒性，疾病，临床治疗和精确环境健康的途径，总体目标 提高中心调查人员的职业生涯，并将与农村暴露有关的新见解转化为 人口健康。成功实现这一目标需要最先进的基础设施， 解决了研究者设计和实施安全的转化研究的关键需求， 研究对象和调查人员，可重复性和严格的科学方法。联同 社区参与核心，IHSFC提高环境健康素养和公共卫生实践 并促进与环境健康科学（EHS）相关的发现的双向沿着翻译 从基础或临床研究到应用或公共卫生领域。的具体目标 IHSFC的目标是1）提供基础设施，以开展与EHS相关的临床和转化研究， 包括a）提供资源以帮助获得使用人类受试者进行临床和 与EHS相关的转化研究; B）招募人类受试者进行临床和转化研究 c）评估和监测肺部和全身生理反应; d）评估和 量化肺损伤（气道和实质）和生理反应的放射学表现; e） 通过向所有成员提供生物统计支持来解决严格性和可重复性问题;以及f）提供生态学 环境卫生研究人员使用移动的进行瞬时评估和健康症状采样 装置. IHSFC将：目标2）确保开展与EHS相关的临床和转化研究 安全地，并保持主题的机密性;目标3）发展参与的社区伙伴关系， 影响临床和公共卫生研究行为的研究人员和社区组织 并支持社区参与奖学金;以及目标4）为早期- 对EHS感兴趣的阶段调查员。IHSFC促进招聘，评估和评估 研究对象和支持成像，心肺生理学测试，生物采样，组织和 生物标本采购，以实现这些目标。IHSFC提供研究设计和数据分析协助， 支持社区参与奖学金，并提供尖端技术来评估和 分析环境空气污染物对肺结构的影响。这项技术可以应用于小动物 如啮齿动物、猪等大型动物和人类，促进相关基本发现的翻译， 暴露在环境中的风险。总体而言，IHSFC整合了促进临床和 EHSRC内部的翻译研究。