Integrated Health Sciences Facility Core

项目摘要-综合卫生科学设施核心（ihsfc）

PROJECT SUMMARY - INTEGRATED HEALTH SCIENCES FACILITY CORE (IHSFC) The Integrated Health Sciences Facility Core (IHSFC) promotes human-centered research on susceptibilities, pathways of toxicity, disease, clinical treatment, and precision environmental health, with the overarching goal to enhance the careers of Center investigators and translating new insights related to rural exposures to population health. Successful accomplishment of this goal requires a state-of-the-art infrastructure that addresses the critical need of investigators to design and implement translational research with safety to both research subjects and investigators, reproducibility, and rigorous scientific approaches. In conjunction with the Community Engagement Core, the IHSFC enhances environmental health literacy and public health practice and facilitates the translation of findings relevant to environmental health science (EHS) bi-directionally along the spectrum from basic or clinical research to the applied or public health arenas. The Specific Aims of the IHSFC are Aim 1) to provide the infrastructure to carry out clinical and translational studies relevant to EHS, including a) providing resources to assist in obtaining approval for the use of human subjects for clinical and translational studies relevant to EHS; b) recruiting human subjects for clinical and translational studies relevant to EHS; c) assessing and monitoring pulmonary and systemic physiologic responses; d) assessing and quantifying radiographic manifestations of lung injury (airway and parenchymal) and physiological responses; e) addressing rigor and reproducibility by providing biostatistical support to all member; and f) providing ecological momentary assessment and health-symptom sampling for environmental health researchers using mobile devices. The IHSFC will: Aim 2) ensure that clinical and translational studies relevant to EHS are carried out safely, and that subject confidentiality is maintained; Aim 3) develop engaged community partnerships between researchers and community-based organizations that impact the conduct of clinical and public health research and support the Community Engagement Fellowship; and Aim 4) provide the infrastructure for training of early- stage investigators with interest in EHS. The IHSFC facilitates the recruitment, evaluation, and assessment of research subjects and supports imaging, cardiopulmonary physiology testing, biologic sampling, and tissue and biospecimen procurement to attain these Aims. The IHSFC provides study design and data analysis assistance, supports a Community Engagement Fellowship, and offers access to cutting-edge technology to evaluate and analyze the effects of ambient air pollutants on lung structures. This technology can be applied to small animals such as rodents, large animals such as pigs, and humans, promoting the translation of basic discoveries related to environmental exposures to humans. Overall, the IHSFC integrates resources that facilitate clinical and translational research studies within the EHSRC.