权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Integrated Health Sciences Facility Core

综合健康科学设施核心

基本信息

批准号：
10649440
负责人：
ALEJANDRO Pierre COMELLAS
金额：
$ 15.5万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-04-01 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10649440
关键词：
Address Air Pollutants Animal Model Animals Area Basic Science Behavior Biological Biometry Blood Vessels Cardiopulmonary Physiology Clinical Clinical Investigator Clinical Research Clinical Research Associate Clinical Treatment Computers Core Facility Data Analyses Disease Doctor of Philosophy Ecological momentary assessment Ensure Environment Environmental Exposure Environmental Health Evaluation Exposure to Faculty Family suidae Fellowship Goals Health Health Sciences Human Image Infrastructure Iowa Lung Monitor National Institute of Environmental Health Sciences Pathway interactions Phenotype Physiological Population Predisposition Process Public Health Public Health Practice Pulmonary function tests Pulmonology Radiology Specialty Reproducibility Research Research Design Research Personnel Research Subjects Research Support Resources Respiratory Function Tests Rodent Rural Safety Sampling Science Scientist Strategic Planning Structure Symptoms Technology Testing Time Tissues Toxic effect Training and Infrastructure Translating Translational Research Translations Universities behavior influence career community engagement community organizations community partnership data to knowledge design experience handheld mobile device health literacy health science research human subject imaging facilities insight interdisciplinary collaboration interest lung injury member population health professor public health research radiological imaging recruit research study research vision response translational study

项目摘要

PROJECT SUMMARY - INTEGRATED HEALTH SCIENCES FACILITY CORE (IHSFC) The Integrated Health Sciences Facility Core (IHSFC) promotes human-centered research on susceptibilities, pathways of toxicity, disease, clinical treatment, and precision environmental health, with the overarching goal to enhance the careers of Center investigators and translating new insights related to rural exposures to population health. Successful accomplishment of this goal requires a state-of-the-art infrastructure that addresses the critical need of investigators to design and implement translational research with safety to both research subjects and investigators, reproducibility, and rigorous scientific approaches. In conjunction with the Community Engagement Core, the IHSFC enhances environmental health literacy and public health practice and facilitates the translation of findings relevant to environmental health science (EHS) bi-directionally along the spectrum from basic or clinical research to the applied or public health arenas. The Specific Aims of the IHSFC are Aim 1) to provide the infrastructure to carry out clinical and translational studies relevant to EHS, including a) providing resources to assist in obtaining approval for the use of human subjects for clinical and translational studies relevant to EHS; b) recruiting human subjects for clinical and translational studies relevant to EHS; c) assessing and monitoring pulmonary and systemic physiologic responses; d) assessing and quantifying radiographic manifestations of lung injury (airway and parenchymal) and physiological responses; e) addressing rigor and reproducibility by providing biostatistical support to all member; and f) providing ecological momentary assessment and health-symptom sampling for environmental health researchers using mobile devices. The IHSFC will: Aim 2) ensure that clinical and translational studies relevant to EHS are carried out safely, and that subject confidentiality is maintained; Aim 3) develop engaged community partnerships between researchers and community-based organizations that impact the conduct of clinical and public health research and support the Community Engagement Fellowship; and Aim 4) provide the infrastructure for training of early- stage investigators with interest in EHS. The IHSFC facilitates the recruitment, evaluation, and assessment of research subjects and supports imaging, cardiopulmonary physiology testing, biologic sampling, and tissue and biospecimen procurement to attain these Aims. The IHSFC provides study design and data analysis assistance, supports a Community Engagement Fellowship, and offers access to cutting-edge technology to evaluate and analyze the effects of ambient air pollutants on lung structures. This technology can be applied to small animals such as rodents, large animals such as pigs, and humans, promoting the translation of basic discoveries related to environmental exposures to humans. Overall, the IHSFC integrates resources that facilitate clinical and translational research studies within the EHSRC.

项目摘要-综合卫生科学设施核心（ihsfc）