A novel manufacturing process for the Net-Zero separation and purification of biobased cadaverine for sustainable fashion application

近年来，能源危机日益严重。全球变暖和化石资源的短缺促使人们寻求一种新的生物经济。尸胺是一种生物基平台化学品，在工业、医药和农业中发挥着不可或缺的作用。特别是，尸胺是聚酰胺和聚氨酯的重要聚合物单体。由于尸胺与1,6-二氨基己烷结构相似，尸胺可以代替1,6-二氨基己烷合成尼龙54、尼龙56、尼龙510、尼龙512等生物基聚酰胺材料。与传统尼龙相比，由尸胺制成的新型尼龙具有密度更低、尺寸稳定性更好等优越性能。例如，尼龙56在生产纺织纤维方面具有显著的优势，因为它的玻璃化转变温度低，吸水率高。低玻璃化转变温度使尼龙56纤维在高山地区表现良好\[1\]，大大提高了材料的耐低温性。高吸收率使尼龙56纤维具有良好的吸湿排汗性能，显著提高穿着舒适性，减少静电。此外，尼龙56具有优异的强度、牢度和耐磨性，增加了衣服的使用寿命。在这个项目中，我们的目标是将这个项目从TRL 4提升到6\。我们的目标是降低能源密集型产品分离和净化过程的成本，这一成本占50亿美元% of the final cadaverine price. The utilization of L-lysine hydrochloride as a substrate for the production of high-purity cadaverine will be investigated by a litre-scale integrated strategy incorporating fermentation, bioproduction, deprotonation, extraction and rectification. Based on the experimental achievement on the integrated process for the production of high-purity cadaverine from lysine decarboxylase, we confirm the lab scale feasibility of a low-cost cadaverine production, which is ready for industrial-scale implementation. To scale up the production, we're aiming to achieve a 99% purity of cadaverine separation, which will offer a large potential profit margin. The price of the as-produced cadaverine is estimated to be 7 times cheaper compared to the commercially available cadaverine. We'll focus on taking this lab-scale production and theoretical simulation to an economically feasible industrial production. Most importantly, we will adopt novel digital modelling and artificial intelligence techniques developed at the University of Manchester to accelerate design and optimisation of the underlying bioprocess, so that we can further improve the sustainability and economic viability of the new bio-material manufacturing technology.

In recent years, the energy crisis has become increasingly serious. Global warming and the shortage of fossil resources has driven the quest for a new bio-economy. Cadaverine is a bio-based platform chemical that plays an indispensable role in industry, medicine and agriculture. In particular, cadaverine is an important polymer monomer for polyamides and polyurethanes. Due to the similar structure of cadaverine and 1,6-diaminohexane, cadaverine can replace 1,6-diaminohexane to synthesize bio-based polyamide materials such as nylon 54, nylon 56, nylon 510 and nylon 512\. Compared to traditional nylons, the new nylons made from cadaverine have a lower density, better dimensional stability and other superior properties. For example, nylon56 has a significant advantage in producing textile fibres owing to its low glass transition temperature and high water absorption. The low glass transition temperature enables nylon 56 fiber to perform well in alpine regions\[1\], and greatly improves the low-temperature resistance of the material. The high absorption rate gives nylon 56fiber good moisture-wicking performance, significantly improving wearing comfort and reducing static electricity. In addition, nylon 56 has excellent strength, fastness and wear resistance, which increases the service life of clothes.In this project, we aim to take this project from TRL 4 to 6\. We aim to reduce the cost of the energy-intensive product separation and purification process, which counts for \>50% of the final cadaverine price. The utilization of L-lysine hydrochloride as a substrate for the production of high-purity cadaverine will be investigated by a litre-scale integrated strategy incorporating fermentation, bioproduction, deprotonation, extraction and rectification. Based on the experimental achievement on the integrated process for the production of high-purity cadaverine from lysine decarboxylase, we confirm the lab scale feasibility of a low-cost cadaverine production, which is ready for industrial-scale implementation. To scale up the production, we're aiming to achieve a 99% purity of cadaverine separation, which will offer a large potential profit margin. The price of the as-produced cadaverine is estimated to be 7 times cheaper compared to the commercially available cadaverine. We'll focus on taking this lab-scale production and theoretical simulation to an economically feasible industrial production. Most importantly, we will adopt novel digital modelling and artificial intelligence techniques developed at the University of Manchester to accelerate design and optimisation of the underlying bioprocess, so that we can further improve the sustainability and economic viability of the new bio-material manufacturing technology.