A novel manufacturing process for the Net-Zero separation and purification of biobased cadaverine for sustainable fashion application

用于可持续时尚应用的生物基尸胺净零分离和纯化的新型制造工艺

• 批准号: 10063534
• 金额: $ 10.73万
• 依托单位: ALGREEN LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10063534
• 关键词: novel; manufacturing; process; Net; Zero

In recent years, the energy crisis has become increasingly serious. Global warming and the shortage of fossil resources has driven the quest for a new bio-economy. Cadaverine is a bio-based platform chemical that plays an indispensable role in industry, medicine and agriculture. In particular, cadaverine is an important polymer monomer for polyamides and polyurethanes. Due to the similar structure of cadaverine and 1,6-diaminohexane, cadaverine can replace 1,6-diaminohexane to synthesize bio-based polyamide materials such as nylon 54, nylon 56, nylon 510 and nylon 512\. Compared to traditional nylons, the new nylons made from cadaverine have a lower density, better dimensional stability and other superior properties. For example, nylon56 has a significant advantage in producing textile fibres owing to its low glass transition temperature and high water absorption. The low glass transition temperature enables nylon 56 fiber to perform well in alpine regions\[1\], and greatly improves the low-temperature resistance of the material. The high absorption rate gives nylon 56fiber good moisture-wicking performance, significantly improving wearing comfort and reducing static electricity. In addition, nylon 56 has excellent strength, fastness and wear resistance, which increases the service life of clothes.In this project, we aim to take this project from TRL 4 to 6\. We aim to reduce the cost of the energy-intensive product separation and purification process, which counts for \>50% of the final cadaverine price. The utilization of L-lysine hydrochloride as a substrate for the production of high-purity cadaverine will be investigated by a litre-scale integrated strategy incorporating fermentation, bioproduction, deprotonation, extraction and rectification. Based on the experimental achievement on the integrated process for the production of high-purity cadaverine from lysine decarboxylase, we confirm the lab scale feasibility of a low-cost cadaverine production, which is ready for industrial-scale implementation. To scale up the production, we're aiming to achieve a 99% purity of cadaverine separation, which will offer a large potential profit margin. The price of the as-produced cadaverine is estimated to be 7 times cheaper compared to the commercially available cadaverine. We'll focus on taking this lab-scale production and theoretical simulation to an economically feasible industrial production. Most importantly, we will adopt novel digital modelling and artificial intelligence techniques developed at the University of Manchester to accelerate design and optimisation of the underlying bioprocess, so that we can further improve the sustainability and economic viability of the new bio-material manufacturing technology.

近年来，能源危机日益严重。全球变暖和化石资源短缺推动了对新生物经济的追求。身体碱是一种以生物为基础的平台化学品，在工业、医药和农业中发挥着不可或缺的作用。特别是，身体碱是聚酰胺和聚氨酯的重要聚合物单体。由于身体碱与1，6-二氨基己烷结构相似，可取代1，6-二氨基己烷合成尼龙54、尼龙56、尼龙510、尼龙512等生物基聚酰胺材料。与传统尼龙相比，由身体制成的新型尼龙具有密度更低、尺寸稳定性更好等优异性能。例如，尼龙56由于其低玻璃化转变温度和高吸水率，在生产纺织纤维方面具有显著的优势。较低的玻璃化转变温度使尼龙56纤维在高寒地区表现良好，大大提高了材料的耐低温性。高吸水率使尼龙56纤维具有良好的吸湿排汗性能，显著提高了穿着舒适性，减少了静电。此外，尼龙56具有优异的强度、牢度和耐磨性，从而延长了服装的使用寿命。在这个项目中，我们的目标是将这个项目从TRL4提高到6。我们的目标是降低能源密集型产品分离和提纯过程的成本，这一过程占最终身体价格的50%。利用L赖氨酸盐酸盐作为生产高纯度身体碱的底物，将采用发酵、生物生产、去质子化、提取和精馏相结合的升规模综合策略进行研究。基于赖氨酸脱羧酶生产高纯度身体碱一体化工艺的实验成果，我们确认了低成本生产身体碱的小试可行性，为工业化生产做好了准备。为了扩大生产规模，我们的目标是达到99%的身体分离纯度，这将提供巨大的潜在利润率。据估计，生产的身体的价格比商业上可买到的身体便宜7倍。我们将专注于将这种实验室规模的生产和理论模拟转化为经济上可行的工业生产。最重要的是，我们将采用曼彻斯特大学开发的新型数字建模和人工智能技术，以加快基础生物工艺的设计和优化，从而进一步提高新生物材料制造技术的可持续性和经济可行性。