The Evidence Project: Systematic Reviews of Critical HIV Interventions, and Disruption in HIV Services from COVID-19 in LMIC

项目总结/摘要 摘要： 尽管有大量和不断增长的关于行为、社会和结构的功效的科学文献， 然而，解释科学文献是一项挑战。确定相关研究是一项时间密集的工作。 从已发表的报告中得出的研究质量需要仔细分析。有相互矛盾的发现， 问题研究研究中使用的样本和研究设计通常不一致。汇总结果 研究还需要先进的统计技术。应对这些挑战的最新战略 使用系统评价和荟萃分析来分析和解释干预措施的效果， 进行了多项研究。在本研究中，我们将进行系统回顾和Meta分析。 分析LMIC的研究，重点是行为，社会或结构干预。有三个关键 我们将分析的领域：（1）旨在支持联系，保留和坚持ART的干预措施， （2）将非艾滋病毒健康问题与艾滋病毒问题相结合的干预措施， 具体的健康问题;以及（3）评估COVID-19疫情对艾滋病毒相关护理的影响，以及 在LMIC预防。此外，我们将添加到我们的严格的数据提取信息的理论 审议中的干预措施的基础，以及关于每项措施的执行特点的数据 干预还将回顾性地进行关于实施特征和理论的数据提取， 所有435项研究，我们以前审查，并添加到我们的数据库。

PROJECT SUMMARY / ABSTRACT Abstract: Despite the vast and ever-growing scientific literature on the efficacy of behavior, social, and structural interventions, interpreting the scientific literature is challenging. Identifying relevant studies is time intensive. The quality of research from published reports requires careful analysis. There are conflicting findings across studies. Metrics and study designs used across studies are typically inconsistent. Pooling results across studies also requires advanced statistical techniques. The state-of-the-art strategy to address these challenges is to use systematic reviews and meta-analyses to analyze and interpret the effects of interventions evidenced with research across multiple studies. In the prposed study we will conduct systematic reviews and meta- analyses on studies from LMIC that focus on behavioral, social, or structural interventions. There are three key areas we will analyze: (1) interventions designed to support linkage, retention, and adherence to ART and PrEP with a focus on modes of service delivery; (2) interventions that integrate non-HIV health issues with HIV- specific health issues; and (3) assessing the impact of the COVID-19 epidemic on HIV-related care and prevention in LMIC. In addition, we will add to our rigorous data extraction information on both the theoretical basis of the interventions under consideration, as well as data on the implementation characteristics of each intervention. Data extraction on implementation characteristics and theory will also be done retrospectively for all 435 studies we have previously reviewed and added to our data repository.