The Evidence Project: Systematic Reviews of Critical HIV Interventions, and Disruption in HIV Services from COVID-19 in LMIC

项目摘要/摘要 摘要： 尽管关于行为、社会和结构性行为的功效的科学文献数量巨大且不断增长 干预，解释科学文献是具有挑战性的。确定相关研究是一项耗时的工作。 已发表报告的研究质量需要仔细分析。在不同的领域有相互矛盾的发现 学习。跨研究使用的指标和研究设计通常是不一致的。将结果汇集在一起 研究还需要先进的统计技术。应对这些挑战的最先进战略 是使用系统评价和荟萃分析来分析和解释干预措施的效果 通过多项研究进行研究。在提出的研究中，我们将进行系统的审查和元 对来自LMIC的侧重于行为、社会或结构性干预的研究进行分析。有三个关键 我们将分析的领域：(1)旨在支持联系、保留和遵守ART和 准备工作，重点放在提供服务的方式上；(2)将非艾滋病毒健康问题与艾滋病毒-- 具体的健康问题；以及(3)评估新冠肺炎疫情对艾滋病毒相关护理和 LMIC中的预防。此外，我们将在我们严格的数据提取中添加关于理论上的 正在审议的干预措施的基础，以及关于每项干预措施执行特点的数据 干预。关于实施特点和理论的数据提取也将追溯到 我们之前审查了所有435项研究并将其添加到我们的数据库中。

PROJECT SUMMARY / ABSTRACT Abstract: Despite the vast and ever-growing scientific literature on the efficacy of behavior, social, and structural interventions, interpreting the scientific literature is challenging. Identifying relevant studies is time intensive. The quality of research from published reports requires careful analysis. There are conflicting findings across studies. Metrics and study designs used across studies are typically inconsistent. Pooling results across studies also requires advanced statistical techniques. The state-of-the-art strategy to address these challenges is to use systematic reviews and meta-analyses to analyze and interpret the effects of interventions evidenced with research across multiple studies. In the prposed study we will conduct systematic reviews and meta- analyses on studies from LMIC that focus on behavioral, social, or structural interventions. There are three key areas we will analyze: (1) interventions designed to support linkage, retention, and adherence to ART and PrEP with a focus on modes of service delivery; (2) interventions that integrate non-HIV health issues with HIV- specific health issues; and (3) assessing the impact of the COVID-19 epidemic on HIV-related care and prevention in LMIC. In addition, we will add to our rigorous data extraction information on both the theoretical basis of the interventions under consideration, as well as data on the implementation characteristics of each intervention. Data extraction on implementation characteristics and theory will also be done retrospectively for all 435 studies we have previously reviewed and added to our data repository.