Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors in Treatment

项目摘要/摘要 蒂米亚·S·诺兰是俄亥俄州立大学护理学院的助理教授。诺兰医生是 响应PAR-18-336，以获得必不可少的技能、知识和指导研究经验 作为一名专注于癌症存活率健康差异研究的护士科学家。她的长期目标 是建立一个独立的研究计划，确定生活质量(QOL)的背景因素 来自代表不足的少数群体的年轻乳腺癌幸存者(18-44岁)，并将研究结果转化为 制定、实施和传播/翻译多层次的生活质量干预措施和政策 改变。获奖期的短期目标包括发展生物行为和 癌症和健康结果的环境贡献者(特别是QOL)，科学过程中的 进行纵向干预和观察性试验，先进的定量方法，手稿 写作和勇气，在她所在的领域建立在年轻人和非洲人中的存在 美国(AA)乳腺癌幸存者。年轻的再生障碍性贫血幸存者报告生活质量(QOL)较差，面临更多 健康的负面社会决定因素(例如，社会经济地位低、获得护理的机会有限、歧视) 而不是年轻的白人幸存者。然而，目前还没有公布的干预措施全面解决生活质量问题(即， 身体、心理、社会和精神健康)。这项建议的目的是 年轻再障患者有针对性的生活质量干预与对照的评估过程和初步结果 接受早期(I-II)和晚期(III)乳腺癌治疗的幸存者。诺兰博士适应了这个Y环境 使用年轻再生障碍性贫血幸存者和医疗保健信息的现有循证干预措施的干预 供应商。我们将进行一项双臂随机对照试验，以评估可行性、可接受性和 Y-环境(主题教育、书面材料和视频)与AN的初步健康相关结果 注意力控制(加强日常护理)。我们将招募40名完成初选的年轻再生障碍性贫血幸存者 乳腺癌治疗(每组20人，有早期和晚期病史的患者比例相等 乳癌分期)。我们将通过研究招募和保留(即研究)来衡量可行性 注册和学习联系完成)和协议可接受性，满意、有用、使用 通过我们的主题关注和策略表制定战略。我们将对定性和定量进行三角测量 来自每个研究联系人的答复，以(A)确定参与者对其可接受性的看法，(B)是否愿意 参与协议的各个方面(参与者负担)，以及(C)自我管理战略的使用。在… 基线、两个月和五个月，我们将检查与健康相关的结果(即，生活质量、精神幸福感、自我 效能感和社会支持)组内和组之间使用描述性和多效果建模 技巧。在获奖期间完成的指导研究将为 Y-环境的疗效试验和未来通过干预确定其他可修改因素。

Project Summary/Abstract Timiya S. Nolan is an Assistant Professor in the College of nursing at The Ohio State University. Dr. Nolan is responding to PAR-18-336 to obtain the skills, knowledge and mentored research experience that are essential for a career as a nurse scientist focusing on cancer survivorship health disparities research. Her long-term goal is to build an independent program of research that identifies contextual factors of quality of life (QOL) among young (18-44) breast cancer survivors from underrepresented minority groups and translates findings to the development, implementation, and dissemination/translation of multi-level QOL interventions and policy changes. The short-term goals for the award period include developing expertise in biobehavioral and environmental contributors to cancer and health outcomes (particularly QOL), scientific processes in the conduct of longitudinal intervention and observational trials, advanced quantitative methods, manuscripts writing and grantsmanship toward building a presence in her respective field among young and African American (AA) breast cancer survivors. Young AA survivors report poorer quality of life (QOL), and face more negative social determinants of health (e.g., low socioeconomic status, limited access to care, discrimination) than young White survivors. Yet, there are no published interventions that comprehensively address QOL (i.e., physical, psychological, social and spiritual well-being) in young AA survivors. This proposal is aimed at evaluating processes and preliminary outcomes of a targeted QOL intervention vs. control in young AA survivors in treatment for early (I-II) & late (III) stage breast cancer. Dr. Nolan adapted this Y-AMBIENT intervention from an existing evidence-based intervention using input from young AA survivors and healthcare providers. We will conduct a two-arm, pilot randomized controlled trial to evaluate feasibility, acceptability, and preliminary health-related outcomes of Y-AMBIENT (themed education, written materials, and videos) vs. an attention control (enhanced usual care). We will recruit 40 young AA survivors who have completed primary breast cancer treatment (n=20 per group and equal representation of those with a history of early and late stage breast cancer within). We will measure feasibility via study recruitment and retention (i.e., study enrollment and study contact completion) and protocol acceptability with satisfaction, usefulness, use of strategies via our Topical Concern and Strategy Sheet. We will triangulate qualitative and quantitative responses from each study contact to (a) identify participants’ perceptions of its acceptability, (b) willingness to participate in aspects of the protocol (participant burden), and (c) use of self-management strategies. At baseline, two-, and five-months, we will examine health-related outcomes (i.e., QOL, spiritual well-being, self- efficacy, and social support) within and between groups using descriptive and multiple-effects modeling techniques. Mentored research accomplished during the award period will lay the foundation for a large efficacy trial of Y-AMBIENT and future identification of other modifiable factors to address with interventions.