Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors

项目概要/摘要 年轻（小于45岁）的非裔美国人（AA）女性更容易患乳腺癌， 报告较差的生活质量（QOL），并面临健康的负面社会决定因素（例如，低社会经济 地位，获得护理的机会有限，歧视）比年轻的白色妇女。然而，没有出版 全面解决QOL的干预措施（即，身心、社会和精神福祉） 年轻的AA幸存者利用年轻的AA幸存者和医疗保健提供者的意见，我们调整了现有的 针对年轻AA幸存者的QOL干预（Y-AMBIENT）。Y-AMBIENT是一个为期四个月的，基于电话的 三次以生活质量为主题的教育会议、三次随访会议、书面材料和视频的干预 旨在改善QOL。我们建议评估目标生活质量的过程和初步结果 早期（I-II）和晚期（III）乳腺癌年轻AA幸存者的干预与注意力控制。我们将 进行一项两组、重复测量的试点研究，以评估可行性、可接受性和初步健康状况- Y-AMBIENT与注意力控制（脚本社会化）的相关结果。我们将招募40名年轻的AA 完成原发性乳腺癌治疗的幸存者（每组n=20， 有早期和晚期乳腺癌病史者）。我们将通过研究来衡量可行性 招聘和保留（即，研究入组和研究联系完成）和方案可接受性， 满意度，有用性，通过我们的主题关注和策略表使用策略。我们会三角定位 每个研究联系人的定性和定量反应，以（a）确定满意度的看法， 有用性，（B）参与方案各方面的意愿（参与者负担），以及（c）使用自我- 自我管理的管理策略。在基线，两个月，五个月，我们将检查健康状况- 相关结果（即，生活质量、精神健康、自我效能和社会支持） 使用描述性和多效应建模技术。本研究将提供初步数据支持 Y-AMBIENT的大型随机对照试验。

Project Summary/Abstract African American (AA) women who are young (less than age 45) are more likely to develop breast cancer, report poorer quality of life (QOL), and face negative social determinants of health (e.g., low socioeconomic status, limited access to care, discrimination) than young White women. Yet, there are no published interventions that comprehensively address QOL (i.e., physical, psychological, social and spiritual well-being) in young AA survivors. Using input from young AA survivors and healthcare providers, we adapted an existing QOL intervention to target young AA survivors (Y-AMBIENT). Y-AMBIENT is a four-month, telephone-based intervention with three QOL-themed education sessions, three follow up sessions, written materials, and videos designed to improve QOL. We propose to evaluate processes and preliminary outcomes of a targeted QOL intervention vs. attention control in young AA survivors of early (I-II) & late (III) stage breast cancer. We will conduct a two-arm, repeated measures pilot study to evaluate feasibility, acceptability, and preliminary health- related outcomes of Y-AMBIENT vs. an attention control (scripted socialization). We will recruit 40 young AA survivors who have completed primary breast cancer treatment (n=20 per group and equal representation of those with a history of early and late stage breast cancer within). We will measure feasibility via study recruitment and retention (i.e., study enrollment and study contact completion) and protocol acceptability with satisfaction, usefulness, use of strategies via our Topical Concern and Strategy Sheet. We will triangulate qualitative and quantitative responses from each study contact to (a) identify perceptions of satisfaction and usefulness, (b) willingness to participate in aspects of the protocol (participant burden), and (c) use of self- management strategies to self-manage concerns. At baseline, two-, and five-months, we will examine health- related outcomes (i.e., QOL, spiritual well-being, self-efficacy, and social support) within and between groups using descriptive and multiple-effects modeling techniques. This study will provide preliminary data to support a large randomized controlled trial of the Y-AMBIENT.