Prometeus - Preterm Brain-Oxygenation and Metabolic EU-Sensing: Feed the Brain

Prometeus - 早产儿脑氧合和代谢 EU 传感：喂养大脑

• 批准号: 10063686
• 金额: $ 18.39万
• 依托单位: UNIVERSITY COLLEGE LONDON
• 依托单位国家: 英国
• 项目类别: EU-Funded
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10063686
• 关键词: Prometeus; Preterm; Brain; Oxygenation; Metabolic

Prometeus introduces a new-paradigm for personalized nutrition of prematurely born neonates in neonatal intensive care unit (NICU), by developing a groundbreaking technology for real-time adjustment of glucose and nutrients intakes to target neonatal brain needs. The brain of a baby born prematurely is highly susceptible to early neonatal injuries that, in turn, increase the risk for neurodevelopmental disability. Provision of adequate nutrients and oxygen is essential for proper brain development and growth. However, current nutritional strategies are unfit to target real-time brain necessities, and are driven by pre-specified (non personalised) nutritional charts, in the absence of contemporary cot-side monitoring of both brain “health” and metabolic supplies. As a consequence, sudden changes of brain fuel-requirements cannot be promptly addressed by real-time adjustment of glucose and nutrients provision. Prometeus will develop a metabolic model of the interaction between the three key brain fuels [glucose, lactate and beta-hydroxybutyrate (BHB)] and their effect on regional cerebral blood flow (CBF), oxygen saturation (StO2) and metabolism (CMRO2). The model will serve to individualize brain nutrition targeting “brain health” according to the inputs derived from two novel minimally invasive metabolic sensing systems: a wearable cap measuring regional CBF, StO2 and CMRO2 and a subcutaneous miniaturized metabolic sensor for glucose, lactate and BHB. The system will create a metabolic “womb” to feed the brain of preterm neonates. Prometeus will be paralleled by a parent-dedicated interface, exploiting a purposely developed family adjusted visual language, that will inform parents of preterm babies during their NICU admission and stay. Prometeus will dramatically reduce the risk for prematurity-associated disability in Europe and worldwide, with a consequent incalculable ethical, social and economic impact.

Prometeus为新生儿重症监护室（NICU）的早产儿引入了个性化营养的新模式，通过开发一种突破性的技术来实时调整葡萄糖和营养素的摄入量，以满足新生儿的大脑需求。早产儿的大脑极易受到早期新生儿损伤的影响，这反过来又会增加神经发育障碍的风险。提供足够的营养和氧气对大脑的正常发育和生长至关重要。然而，目前的营养策略不适合针对实时大脑必需品，并且由预先指定的（非个性化的）营养图表驱动，缺乏对大脑“健康”和代谢供应的当代床侧监测。因此，大脑燃料需求的突然变化不能通过实时调整葡萄糖和营养物质供应来迅速解决。Prometeus将开发三种关键大脑燃料[葡萄糖，乳酸盐和β-羟基丁酸盐（BHB）]之间相互作用的代谢模型及其对局部脑血流量（CBF），氧饱和度（StO 2）和代谢（CMRO 2）的影响。该模型将根据两种新型微创代谢传感系统的输入来个性化针对“大脑健康”的大脑营养：测量区域CBF，StO 2和CMRO 2的可穿戴帽和用于葡萄糖，乳酸盐和BHB的皮下微型代谢传感器。该系统将创造一个代谢“子宫”来喂养早产儿的大脑。Prometeus将由父母专用的界面支持，利用专门开发的家庭调整视觉语言，在新生儿重症监护病房住院期间通知早产儿的父母。Prometeus将大大降低欧洲和全球早产相关残疾的风险，从而产生不可估量的伦理、社会和经济影响。