Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm

早产儿先天性心脏病新生儿脑损伤与脑发育不良。 摘要： 早产和先天性心脏病（CHD）是围产期发病率的两个最常见的来源 在高资源国家。这两种情况都与获得性脑损伤和不良反应有关。 神经发育结果。关于新生儿先天性心脏病的综合风险知之甚少。 早产儿的心脏病以及这种风险如何受到姑息治疗或 决定性的外科手术策略来修复心脏缺陷。除了脑损伤，越来越多的遗传 在CHD中已经确定了可能导致ND结局的异常。我们丰富的经验 对患有CHD的足月儿和未患CHD的早产儿进行成像，结合高且不断增加的 这两个中心的弱势群体使我们能够独特地描述 获得性脑损伤以及早产CHD新生儿的脑发育比较 干预策略。我们的长期目标是优化神经发育结果。在本提案中，我们 将利用跨中心实践在手术干预时机和选择方面的差异性，姑息性与 明确的，以确定手术干预策略与脑发育和脑损伤风险之间的关系。 损伤我们还将进行全面的遗传评估，以确定遗传异常如何改变 脑损伤易感性和ND结局。

Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm. Abstract: Preterm birth and congenital heart disease (CHD) are two of the most common sources of perinatal morbidity in high resource countries. Both conditions are associated with acquired brain injury and adverse neurodevelopmental outcomes. Very little is known about the combined risk for newborns with congenital heart disease that are born preterm and how this risk is affected by variable approaches to palliative or definitive surgical strategies to repair heart defects. In addition to brain injury, an increasing number of genetic anomalies have been identified in CHD that may contribute to ND outcomes. Our extensive experience imaging term babies with CHD and preterm babies without CHD, combined with high and increasing volume of this vulnerable population at our two centers uniquely positions us to describe the risk and magnitude of acquired brain injury as well as comparative brain development in CHD newborns born preterm with respect to intervention strategies. Our long-term goal is to optimize neurodevelopmental outcomes. In this proposal, we will leverage cross-center practice variability in timing and choice of surgical interventions, palliative versus definitive, to determine the association of surgical intervention strategy with brain development and risk of brain injury. We will also perform a comprehensive genetic evaluation to determine how genetic anomalies alter susceptibility to brain injury and ND outcome.