Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm

早产儿先天性心脏病新生儿脑损伤与发育不全 摘要： 早产和先天性心脏病是围产期发病率最常见的两个来源 在资源丰富的国家。这两种情况都与获得性脑损伤有关，并对 神经发育结果。关于新生儿先天性心脏病的综合风险知之甚少。 早产儿的心脏病，以及不同的姑息或治疗方法如何影响这种风险 修复心脏缺陷的明确外科策略。除了脑损伤，越来越多的遗传性疾病 CHD中发现的异常可能与ND的预后有关。我们丰富的经验 对患有CHD的足月儿和没有CHD的早产儿进行成像，并结合高容量和不断增加的 我们这两个中心的弱势群体使我们能够独一无二地描述 先心病早产儿获得性脑损伤与脑发育的比较 干预策略。我们的长期目标是优化神经发育结果。在这项提案中，我们 将利用跨中心实践的可变性，在手术干预的时机和选择上，姑息性与 确定手术干预策略与脑发育和脑风险的关系 受伤。我们还将进行全面的基因评估，以确定基因异常是如何改变的 脑损伤易感性和ND结局。

Brain Injury and Dysmaturation in Newborns with Congenital Heart Disease Born Preterm. Abstract: Preterm birth and congenital heart disease (CHD) are two of the most common sources of perinatal morbidity in high resource countries. Both conditions are associated with acquired brain injury and adverse neurodevelopmental outcomes. Very little is known about the combined risk for newborns with congenital heart disease that are born preterm and how this risk is affected by variable approaches to palliative or definitive surgical strategies to repair heart defects. In addition to brain injury, an increasing number of genetic anomalies have been identified in CHD that may contribute to ND outcomes. Our extensive experience imaging term babies with CHD and preterm babies without CHD, combined with high and increasing volume of this vulnerable population at our two centers uniquely positions us to describe the risk and magnitude of acquired brain injury as well as comparative brain development in CHD newborns born preterm with respect to intervention strategies. Our long-term goal is to optimize neurodevelopmental outcomes. In this proposal, we will leverage cross-center practice variability in timing and choice of surgical interventions, palliative versus definitive, to determine the association of surgical intervention strategy with brain development and risk of brain injury. We will also perform a comprehensive genetic evaluation to determine how genetic anomalies alter susceptibility to brain injury and ND outcome.