Infrastructure and Opportunity Fund Management Core

基础设施和机会基金管理核心

基本信息

  • 批准号:
    10396000
  • 负责人:
  • 金额:
    $ 44.45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-04-01 至 2024-03-31
  • 项目状态:
    已结题

项目摘要

IOFM Core: Infrastructure and Opportunities Management Core Project Summary The NIH Cooperative Centers on Human Immunology (CCHI) program was designed to promote research in human immunology by providing funding for 8-10 Programs as well as additional financial support for pilot projects, new resource and reagent development and/or cross-program collaborative efforts. These developmental awards are made possible through funding provided by the Infrastructure and Opportunity Fund (IOF) grant. The Infrastructure and Opportunity Fund grant is awarded to one of the Programs supported through the CCHI U19 mechanism. The institution that receives the Infrastructure and Opportunity Funds grant is responsible for establishing an Infrastructure and Opportunity Fund Management Core (IOFMC). The IOFMC works with the NIH Program officers and the CCHI scientific steering committee to solicit, review and distribute Infrastructure and Opportunity Funds as subawards to researchers at the IOFMC parent institution and investigators working at other institutions, who are, in many cases, members of one of the other funded CCHI cooperative centers. The IOFMC is responsible for administrative oversight of the subawards and for ensuring that the recipient of the award and the institution in which they work are in compliance with all applicable state, NIH and federal regulations and that charges to the subaward are reasonable and allowable. Finally, the IOFMC must also provide annual financial reports on the awarded subcontracts to NIH. The major goal of the UAB IOFMC will be to establish an administrative structure that will manage the subaward program from the request for applications (RFA) stage, to the pre- and post-award process, and through the grant close- out and reporting phase. In order to meet this goal, we will: (i) coordinate the IOF project application and selection process; (ii) establish subcontracts to distribute IOF development and pilot project grants to Project Leaders at other institutions; (iii) provide administrative and fiscal oversight of these subawards; and (iv) serve as the communications interface between IOF awardees, the CCHI steering committee and the NIH. Successful and timely completion of these objectives by the UAB IOFMC will allow the NIH to leverage the intellectual, infrastructure and unique reagents/samples that are present in the CCHI network institutions to advance the overall scientific goals of the CCHI program.
IOFM核心:基础设施和机会管理核心 项目摘要 美国国立卫生研究院人类免疫学合作中心(CCHI)计划旨在促进 人类免疫学,为8-10个项目提供资金,并为Pilot提供额外的财政支持 项目、新资源和试剂开发和/或跨计划的协作工作。这些 发展奖是通过基础设施和机会基金提供的资金实现的 (IOF)拨款。基础设施和机会基金赠款授予其中一个受支持的计划 通过CCHI U19机制。接受基础设施和机会基金赠款的机构 负责建立基础设施和机会基金管理核心(IOFMC)。这个 IOFMC与NIH计划官员和CCHI科学指导委员会合作,征求、审查和 将基础设施和机会基金作为子奖分配给IOFMC母机构的研究人员 以及在其他机构工作的调查人员,在许多情况下,他们是其他资助机构之一的成员 CCHI合作中心。IOFMC负责对分奖的行政监督和 确保获奖者及其工作机构遵守所有 适用的州、NIH和联邦法规,并且对分奖收取的费用是合理和允许的。 最后,IOFMC还必须向NIH提供授予分包合同的年度财务报告。少校 UAB IOFMC的目标将是建立一个管理分奖计划的行政结构 从申请申请(RFA)阶段,到授予前和授予后过程,以及通过赠款结束- 出局和报告阶段。为了实现这一目标,我们将:(I)协调IOF项目申请和 遴选过程;(2)建立分包合同,将IOF开发和试点项目赠款分配给项目 其他机构的领导人;(3)对这些次级奖励进行行政和财政监督;(4) 作为IOF获奖者、CCHI指导委员会和NIH之间的沟通接口。 UAB IOFMC成功和及时地完成这些目标将使NIH能够利用 CCHI网络机构中存在的智力、基础设施和独特的试剂/样本 推进CCHI计划的总体科学目标。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Frances E. Lund其他文献

Transcription factor T-bet regulates the maintenance and differentiation potential of lymph node and lung effector memory B cell subsets
转录因子 T 细胞结合抑制因子调节淋巴结和肺效应记忆 B 细胞亚群的维持和分化潜能
  • DOI:
    10.1016/j.immuni.2025.05.021
  • 发表时间:
    2025-07-08
  • 期刊:
  • 影响因子:
    26.300
  • 作者:
    Christopher A. Risley;Michael D. Schultz;S. Rameeza Allie;Shanrun Liu;Jessica N. Peel;Anoma Nellore;Christopher F. Fucile;Christopher D. Scharer;Jeremy M. Boss;Troy D. Randall;Alexander F. Rosenberg;Frances E. Lund
  • 通讯作者:
    Frances E. Lund
IgM Memory Cells: First Responders in Malaria
  • DOI:
    10.1016/j.immuni.2016.08.005
  • 发表时间:
    2016-08-16
  • 期刊:
  • 影响因子:
  • 作者:
    Sara L. Stone;Frances E. Lund
  • 通讯作者:
    Frances E. Lund
This information is current as Infection in Mice Pneumocystis Clearance of T Cells for + Early Priming of CD 4 B Lymphocytes Are Required during the Feola
此信息是最新的,因为小鼠肺孢子虫感染在 Feola 期间需要清除 T 细胞以早期启动 CD 4 B 淋巴细胞
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    M. Opata;M. Hollifield;Frances E. Lund;Troy D. Randall;Robert Dunn;B. Garvy;D. Feola
  • 通讯作者:
    D. Feola
Signaling through CD38 augments B cell antigen receptor (BCR) responses and is dependent on BCR expression.
通过 CD38 的信号传导可增强 B 细胞抗原受体 (BCR) 反应,并且依赖于 BCR 表达。
  • DOI:
    10.4049/jimmunol.157.4.1455
  • 发表时间:
    1996
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Frances E. Lund;N.;K. M. Kim;M. Reth;Maureen Howard
  • 通讯作者:
    Maureen Howard
This information is current as MechanismsStrains of Influenza via Multiple B Cells Promote Resistance to Heterosubtypic and
该信息是最新的,因为机制流感菌株通过多个 B 细胞促进对异亚型和
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. Rangel;D. Carragher;Ravi S. Misra;Kim L. Kusser;Louise Hartson;A. Moquin;Frances E. Lund;T. Randall
  • 通讯作者:
    T. Randall

Frances E. Lund的其他文献

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{{ truncateString('Frances E. Lund', 18)}}的其他基金

TLR7 and TLR9-directed plasma cell formation: Dissecting the molecular basis for their differential dependence on IFN-induced signals
TLR7 和 TLR9 定向浆细胞形成:剖析它们对 IFN 诱导信号的差异依赖性的分子基础
  • 批准号:
    10642784
  • 财政年份:
    2020
  • 资助金额:
    $ 44.45万
  • 项目类别:
TLR7 and TLR9-directed plasma cell formation: Dissecting the molecular basis for their differential dependence on IFN-induced signals
TLR7 和 TLR9 定向浆细胞形成:剖析它们对 IFN 诱导信号的差异依赖性的分子基础
  • 批准号:
    10431929
  • 财政年份:
    2020
  • 资助金额:
    $ 44.45万
  • 项目类别:
Tissue and organ specific human B cell immunity
组织和器官特异性人类 B 细胞免疫
  • 批准号:
    10265689
  • 财政年份:
    2020
  • 资助金额:
    $ 44.45万
  • 项目类别:
TLR7 and TLR9-directed plasma cell formation: Dissecting the molecular basis for their differential dependence on IFN-induced signals
TLR7 和 TLR9 定向浆细胞形成:剖析它们对 IFN 诱导信号的差异依赖性的分子基础
  • 批准号:
    10032785
  • 财政年份:
    2020
  • 资助金额:
    $ 44.45万
  • 项目类别:
Identification and characterization of effector memory B cell populations that dominate memory responses to subsequent influenza infection and vaccination
效应记忆 B 细胞群的鉴定和表征,该细胞群主导对随后流感感染和疫苗接种的记忆反应
  • 批准号:
    10227903
  • 财政年份:
    2020
  • 资助金额:
    $ 44.45万
  • 项目类别:
TLR7 and TLR9-directed plasma cell formation: Dissecting the molecular basis for their differential dependence on IFN-induced signals
TLR7 和 TLR9 定向浆细胞形成:剖析它们对 IFN 诱导信号的差异依赖性的分子基础
  • 批准号:
    10214491
  • 财政年份:
    2020
  • 资助金额:
    $ 44.45万
  • 项目类别:
Identification and characterization of effector memory B cell populations that dominate memory responses to subsequent influenza infection and vaccination
效应记忆 B 细胞群的鉴定和表征,该细胞群主导对随后流感感染和疫苗接种的记忆反应
  • 批准号:
    10455632
  • 财政年份:
    2020
  • 资助金额:
    $ 44.45万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10395996
  • 财政年份:
    2019
  • 资助金额:
    $ 44.45万
  • 项目类别:
Characterization of virus-specific human B cell subsets in lymphoid and non-lymphoid tissues
淋巴和非淋巴组织中病毒特异性人类 B 细胞亚群的表征
  • 批准号:
    10592418
  • 财政年份:
    2019
  • 资助金额:
    $ 44.45万
  • 项目类别:
Tissue and organ specific human B cell immunity
组织和器官特异性人类 B 细胞免疫
  • 批准号:
    10592408
  • 财政年份:
    2019
  • 资助金额:
    $ 44.45万
  • 项目类别:

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