Using partners to enhance long-term weight loss

利用合作伙伴来促进长期减肥

• 批准号: 10396455
• 负责人: Corrine Ione Voils
• 金额: $ 56.29万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-20 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10396455
• 关键词: Address; Adult; Affect; Age; Behavior; Behavior Therapy; Behavioral; Body Weight decreased; Body mass index; Caloric Restriction; Car Phone; Communication; Coping Behavior; Coping Skills; Counseling; Couples; Diet; Diet Monitoring; Dietary intake; Domestic Partners; Educational process of instructing; Effectiveness; Eligibility Determination; Energy Intake; Evaluation; Fatty acid glycerol esters; Frequencies; Future; Goals; Health; Health Care Costs; Health behavior change; Health system; Individual; Insurance Carriers; Intake; Intervention; Joints; Knowledge; Learning; Life Style; Maintenance; Mediating; Mediation; Mediator of activation protein; Methodology; Modeling; Monitor; Motivation; Obesity; Outcome; Overweight; Participant; Patient-Focused Outcomes; Patients; Persons; Pharmaceutical Preparations; Physical Function; Physical activity; Prevalence; Quality of life; Randomized; Relapse; Risk Factors; Role; Social Environment; Social support; Source; Specific qualifier value; Spouses; Telephone; Testing; Text Messaging; Training; United States; Visit; Weight; Weight Gain; Weight maintenance regimen; Work; arm; bariatric surgery; base; behavior change; cardiovascular disorder risk; clinically significant; commune; comorbidity; coping; cost effective; cost effectiveness; design; dietary; dietary restriction; disorder later incidence prevention; efficacy outcomes; efficacy testing; evidence base; hypercholesterolemia; improved; insight; intervention effect; novel; obesity treatment; patient subsets; preventable death; primary outcome; programs; secondary outcome; skills; skills training; theories; treatment as usual; weight loss program; weight maintenance

Abstract Obesity is the second leading cause of preventable deaths in the United States. Weight loss, and maintenance of weight loss, improves cardiovascular disease risk factors, physical functioning, and quality of life. Interventions that combine dietary change, physical activity increase, and behavioral strategies are efficacious for short-term weight loss but less so for long-term weight loss. Given that the best predictor of long-term weight loss is initial weight loss, strategies are needed to enhance both initial weight loss and weight loss maintenance. Dietary and physical activity behaviors often are influenced by domestic partners. Therefore, intervening jointly on patients and their partners is likely to improve the efficacy of weight management programs. This study involves an evaluation of the role of domestic partner support in a comprehensive weight loss initiation and maintenance program. Eligibility criteria include age 18-75, BMI ≥27 kg/m2 with an obesity- related comorbidity or BMI ≥30 kg/m2, and cohabitating with a domestic partner. 230 couples will be randomized to 18-month comprehensive weight program directed at patients alone or involving their partners. In months 1-6, all patients will receive group-based weight loss program featuring a calorie-restricted diet and physical activity. In months 7-18, all patients will receive a weight loss maintenance intervention that involves maintenance-specific content, transitions to individual telephone calls, and gradually decreases in frequency of contact. In the partner-assisted arm, partners will learn and practice communication skills and support strategies to facilitate patient health behavior change. Partners will attend patient group sessions, be informed of patients' goals (during initiation) and relapse plans (during maintenance), and receive reinforcing text messages. In months 19-24, intervention will be withdrawn to examine sustainability of effects. Our primary hypothesis is that average 24-month weight in the partner-assisted intervention will be at least 2.5 kg lower than in the patient-only intervention. Secondary outcomes include caloric intake and physical activity at 24 months. Mediation analyses will examine the role of interdependence theory constructs and social support. If successful, this approach could inform refinement and implementation of effective obesity treatments.

摘要 肥胖是美国可预防死亡的第二大原因。减肥和保养 减肥，改善心血管疾病的危险因素，身体功能和生活质量。 结合联合收割机饮食改变、增加体力活动和行为策略的干预措施是有效的 对于短期减肥，但对于长期减肥来说就不那么重要了。考虑到长期的最佳预测因素 减肥是初始减肥，需要策略来增强初始减肥和减肥 上维护饮食和体育活动行为往往受到家庭伴侣的影响。因此，我们认为， 对患者及其伴侣进行联合干预可能会提高体重管理的效果 程序.本研究涉及家庭伴侣支持作用的综合评价权重 损失启动和维护程序。合格标准包括年龄18-75岁，BMI ≥27 kg/m2，肥胖- 相关合并症或BMI ≥30 kg/m2，并与家庭伴侣同居。230对夫妇将 随机分配到18个月的综合体重计划，针对单独的患者或涉及他们的伴侣。 在第1-6个月，所有患者将接受基于小组的减肥计划，其特点是限制热量饮食， 体力活动。在7-18个月，所有患者将接受减肥维持干预，包括 维护特定的内容，过渡到个人电话，并逐渐减少频率 contact.在合作伙伴协助的手臂，合作伙伴将学习和实践沟通技巧和支持 促进患者健康行为改变的策略。合作伙伴将参加患者小组会议， 患者的目标（在启动期间）和复发计划（在维持期间），并收到强化文本 充分和传播在第19-24个月，将撤回干预措施，以审查影响的可持续性。我们的首要 假设在伴侣协助的干预中，24个月的平均体重将至少降低2.5 kg 而不是只对病人进行干预。次要结果包括24岁时的热量摄入和体力活动 个月中介分析将研究相互依存理论结构和社会支持的作用。如果 如果成功，这种方法可以为有效的肥胖治疗的改进和实施提供信息。

项目成果

A Method to Deliver Automated and Tailored Intervention Content: 24-month Clinical Trial.

• DOI: 10.2196/38262
• 发表时间: 2022-09-06
• 期刊: JMIR FORMATIVE RESEARCH
• 影响因子: 2.2
• 作者: Miller, Hailey N.;Voils, Corrine, I;Cronin, Kate A.;Jeanes, Elizabeth;Hawley, Jeffrey;Porter, Laura S.;Adler, Rachel R.;Sharp, Whitney;Pabich, Samantha;Gavin, Kara L.;Lewis, Megan A.;Johnson, Heather M.;Yancy, William S., Jr.;Gray, Kristen E.;Shaw, Ryan J.
• 通讯作者: Shaw, Ryan J.

Primary outcomes from Partner2Lose: A randomized controlled trial to evaluate partner involvement on long-term weight loss.

Partner2Lose 的主要结果：一项评估伴侣参与长期减肥的随机对照试验。

• DOI: 10.21203/rs.3.rs-4001003/v1
• 发表时间: 2024
• 期刊: Research square
• 作者: Voils,Corrine;Shaw,Ryan;Gavin,Kara;Hetzel,Scott;Lewis,Megan;Pabich,Samantha;Johnson,Heather;Elwert,Felix;Mao,Lu;Gray,Kristen;Yuroff,Alice;Garza,Katya;Yancy,William;Porter,Laura
• 通讯作者: Porter,Laura