多巴胺系统作为冰毒滥用者艾滋病毒状况和炎症的报告者-猫眼课题宝

多巴胺系统作为冰毒滥用者艾滋病毒状况和炎症的报告者

批准号：

10398692

负责人：

Maria Cecilia Garibaldi Marcondes

金额：

$0.63万

依托单位：

SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

2021

资助国家：

美国

项目状态：

已结题

起止时间：

2021-02-01 至 2024-01-31

来源：

https://reporter.nih.gov/project-details/10398692

关键词：

Affinity Age Agonist Behavior Big Data Biological Process Blood Cells Blood donor Brain CCR5 gene Cell surface Cells Cellular Indexing of Transcriptomes and Epitopes by Sequencing Central Nervous System Diseases Cognitive Computer software Critical Thinking DNA DRD1 gene DRD4 gene Data Set Dopamine Dopamine Receptor Drug Exposure Environment Exercise Frequencies Genes Genetic Genetic Polymorphism Genetic Transcription Genomics Genotype HIV HIV Infections HIV Receptors Human IL6 gene Immune Immune Targeting Immune response Immune system In Vitro Individual Individual Differences Infection Inflammation Inflammatory Intake Interleukin-10 Internships Learning Leukocytes Life Expectancy Link METH abuser Mathematics Measures Methamphetamine Methods Microglia Modeling Molecular National Institute of Drug Abuse National NeuroAids Tissue Consortium Neuraxis Neuroimmune Neurologic Neurological outcome Neurotransmitters Opioid Organ Outcome Pathogenesis Pattern Performance Peripheral Peripheral Blood Mononuclear Cell Pharmaceutical Preparations Plasma Predisposition Protein Isoforms RARG gene RNA Reporter Rewards Risk Role S100A8 gene Sequence Alignment Signal Transduction Single Nucleotide Polymorphism Specimen Statistical Data Interpretation Statistical Models Students System Systems Biology Testing Training Viral Viral reservoir Virus Virus Diseases Virus Latency cell type chronic infection co-infection cognitive performance comorbidity cytokine dopamine system dopamine transporter drug abuser experimental study inflammatory marker inflammatory milieu innate immune function insight large datasets macrophage methamphetamine use methamphetamine user neuroAIDS neuroinflammation neuropathology peripheral blood polysubstance use programs receptor social substance use substance user summer internship summer research tool viral DNA viral RNA virology virtual

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2021 NIDA Summer Research Internship Program Systems Biology Approaches to identify Biological Processes associated with Genomic effects of Dopamine in HIV-infected Macrophages Abstract Macrophages, microglia and other immune cells that are targets of Human Immunodeficiency Virus infection express receptors to dopamine, a neurotransmitter that is highly increased in the brain of stimulant drug abusers, including Methamphetamine. Our lab has performed single cell CITE-seq experiments to determine the role of dopamine in reactivating on maintaining the viral reservoir. The Summer Internship student will learn to analyze large sets of data to produce integrated models of biomolecular networks. The student will be virtually trained to administer systems biology strategies to big data and learn state-of-the-art methods for predicting gene networks expressing synchronized behaviors. At the end of the internship, the student will master a systems biology software, while exercising critical thinking, and produce results from our data set.

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