A Synchrotron Radiation Structural Biology Resource

摘要/摘要 - P30GM133894 同步辐射 (SR) 是一种极其明亮且可调谐的 X 射线源，可实现前沿 结构分子生物学（SMB）研究。 “同步加速器结构生物学”的目标 斯坦福同步辐射光源 (SSRL) 的资源”，以下简称 简单来说就是“资源”，就是为用户提供访问集成的、成熟的 SMB 功能的机会 最先进的同步加速器光束线设施，用于大分子晶体学、X 射线 吸收/发射/成像光谱和小角度 X 射线散射/衍射。这些 三个领域构成了该资源的三个技术运营核心。特别强调的是 创建简化的用户访问，提供专门的用户支持和服务，培训用户，以及 就这些专业但成熟的能力的科学效益进行宣传 为生物医学研究界提供设施。多种创新准入机制 正在提供，包括访问核心的单技术和多技术方法， 基于透明且稳健的外部同行评审流程。多方面的培训和 外展计划包括个人培训、研讨会、暑期学校、在途培训和 由经验丰富的科学和技术人员为临床部门提供支持。资源门户网站 提供精简的科学、技术、培训、外展和行政材料以及其他 相关信息。主要目标是优化和维护，以实现可靠和前沿 性能、实验设施和仪器、探测器、软件和计算以及 SSRL 资源的 8 条光束线上的网络功能，利用高 SR X 射线 SSRL 第三代存储环 SPEAR3 的性能，以及 LCLS 的 MFX 站。一个 多设施提案机制有助于获得互补的 Cryo-EM 和 LCLS SLAC 现场站。专门关注用户培训、支持和服务， 资源使生物医学领域具有挑战性的常规项目取得科学成功 科学。

Summary/Abstract - P30GM133894 Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL), hereafter referred to as simply “Resource”, is to provide users access to integrated, mature SMB capabilities utilizing state-of-the-art synchrotron beam line facilities for macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small angle x-ray scattering/diffraction. These three areas comprise the Resource’s three Technical Operations Cores. Special emphasis is to create streamlined user access, provide dedicated user support and services, to train users, and to perform outreach on the scientific benefits of the capabilities of these specialized, yet mature facilities to the biomedical research community. Multiple innovative access mechanisms are being provided, that include both single- and multiple-technique approaches to access the Cores, based on a transparent and robust external peer-review process. A multifaceted training and outreach program includes individual training, workshops, summer schools, on-the-road, and support clinic segments by experienced scientific and technical staff. A Resource web portal provides streamlined scientific, technical, training, outreach and administrative material and other relevant information. A principal aim is to optimize and maintain, for reliable and forefront performance, experimental facilities and instrumentation, detectors, software and computing and network capabilities on the Resource’s 8+ beam lines at SSRL, capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3, and at the MFX station at LCLS. A multi-facility proposal mechanism facilitates access to complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user training, support and service, the Resource enables the scientific success for challenging and routine projects in the biomedical sciences.