A Synchrotron Radiation Structural Biology Resource

同步辐射结构生物学资源

• 批准号: 10668710
• 负责人: KEITH O HODGSON
• 金额: $ 310.02万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10668710
• 关键词: Area; Automation; Biological; Biomedical Research; Clinic; Collaborations; Communities; Complement; Computer software; Cryoelectron Microscopy; Crystallography; Data; Data Analyses; Data Collection; Detection; Development; Education and Outreach; Educational workshop; Facility Accesses; Funding; Generations; Goals; Grant; Health; Human; Image; Imaging Device; Individual; Instruction; Investments; Laboratories; Leadership; Life; Light; Measurement; Membrane Lipids; Mentors; Methodology; Methods; Molecular Biology; National Institute of General Medical Sciences; Peer Review; Performance; Privatization; Process; Productivity; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Roentgen Rays; Schools; Science; Services; Site; Source; Spectrum Analysis; Structure; Synchrotrons; Techniques; Technology; Time; Training; Training Programs; Training Support; United States National Institutes of Health; Work; X ray spectroscopy; X-Ray Crystallography; absorption; base; biological systems; computer cluster; computerized data processing; data quality; detector; experience; experimental study; flexibility; human disease; innovation; instrument; instrumentation; new technology; novel therapeutics; online resource; operation; outreach; outreach program; programs; ranpirnase; spectroscopic imaging; structural biology; success; synchrotron radiation; technological innovation; theories; tool; web portal; web-based tool; x-ray free-electron laser

Summary/Abstract - P30GM133894 Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL), hereafter referred to as simply “Resource”, is to provide users access to integrated, mature SMB capabilities utilizing state-of-the-art synchrotron beam line facilities for macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small angle x-ray scattering/diffraction. These three areas comprise the Resource’s three Technical Operations Cores. Special emphasis is to create streamlined user access, provide dedicated user support and services, to train users, and to perform outreach on the scientific benefits of the capabilities of these specialized, yet mature facilities to the biomedical research community. Multiple innovative access mechanisms are being provided, that include both single- and multiple-technique approaches to access the Cores, based on a transparent and robust external peer-review process. A multifaceted training and outreach program includes individual training, workshops, summer schools, on-the-road, and support clinic segments by experienced scientific and technical staff. A Resource web portal provides streamlined scientific, technical, training, outreach and administrative material and other relevant information. A principal aim is to optimize and maintain, for reliable and forefront performance, experimental facilities and instrumentation, detectors, software and computing and network capabilities on the Resource’s 8+ beam lines at SSRL, capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3, and at the MFX station at LCLS. A multi-facility proposal mechanism facilitates access to complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user training, support and service, the Resource enables the scientific success for challenging and routine projects in the biomedical sciences.

摘要/摘要-P30 GM 133894 同步辐射（SR）是一种非常明亮和可调谐的X射线源， 结构分子生物学（SMB）“同步加速器结构生物学”的目标是 资源”在斯坦福大学同步辐射光源（SSRL），以下简称为 简称“资源”，是为用户提供对集成的成熟SMB功能的访问， 用于高分子晶体学、x射线和 吸收/发射/成像光谱和小角X射线散射/衍射。这些 三个领域构成了资源的三个技术操作核心。特别强调的是 创建简化的用户访问，提供专门的用户支持和服务，以培训用户，以及 对这些专业化的，但成熟的能力的科学效益进行推广， 生物医学研究社区的设施。多种创新的准入机制， 提供的，包括单一和多种技术方法来访问核心， 基于透明和强有力的外部同行审查程序。多方面的培训和 外展计划包括个人培训，讲习班，暑期学校，在路上， 由经验丰富的科学和技术人员支持诊所部门。资源门户网站 提供精简的科学、技术、培训、外联和行政材料以及其他 相关信息一个主要的目标是优化和维护，为可靠和前沿 性能、实验设施和仪器、探测器、软件和计算， 在SSRL的资源的8+波束线上的网络能力，利用高SR X射线 SSRL的第三代储存环SPEAR 3的性能，并在LCLS的MFX站。一 多设施提案机制促进获得互补的Cryo-EM和LCLS 在SLAC的站点。通过专注于用户培训、支持和服务， 资源使生物医学领域具有挑战性的常规项目取得科学成功 以理工科为重