A Synchrotron Radiation Structural Biology Resource

同步辐射结构生物学资源

• 批准号: 10579751
• 负责人: KEITH O HODGSON
• 金额: $ 26.59万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10579751
• 关键词: Area; Automation; Biological; Biomedical Research; Clinic; Collaborations; Communities; Complement; Computer software; Cryoelectron Microscopy; Crystallography; Data; Data Analyses; Data Collection; Detection; Development; Education and Outreach; Educational workshop; Facility Accesses; Funding; Generations; Goals; Grant; Health; Human; Image; Imaging Device; Individual; Instruction; Investments; Laboratories; Leadership; Life; Light; Measurement; Membrane Lipids; Mentors; Methodology; Methods; Molecular Biology; National Institute of General Medical Sciences; Peer Review; Performance; Privatization; Process; Productivity; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Roentgen Rays; Schools; Science; Services; Site; Source; Spectrum Analysis; Structure; Synchrotrons; Techniques; Technology; Time; Training; Training Programs; Training Support; United States National Institutes of Health; Work; X ray spectroscopy; X-Ray Crystallography; absorption; base; biological systems; computer cluster; computerized data processing; data quality; detector; experience; experimental study; flexibility; human disease; innovation; instrument; instrumentation; new technology; novel therapeutics; online resource; operation; outreach; outreach program; programs; ranpirnase; spectroscopic imaging; structural biology; success; synchrotron radiation; technological innovation; theories; tool; web portal; web-based tool; x-ray free-electron laser

Summary/Abstract - P30GM133894 Synchrotron radiation (SR) is an extremely bright and tunable x-ray source that enables forefront research in structural molecular biology (SMB). The goal of “A Synchrotron Structural Biology Resource" at the Stanford Synchrotron Radiation Lightsource (SSRL), hereafter referred to as simply “Resource”, is to provide users access to integrated, mature SMB capabilities utilizing state-of-the-art synchrotron beam line facilities for macromolecular crystallography, x-ray absorption/emission/imaging spectroscopy and small angle x-ray scattering/diffraction. These three areas comprise the Resource’s three Technical Operations Cores. Special emphasis is to create streamlined user access, provide dedicated user support and services, to train users, and to perform outreach on the scientific benefits of the capabilities of these specialized, yet mature facilities to the biomedical research community. Multiple innovative access mechanisms are being provided, that include both single- and multiple-technique approaches to access the Cores, based on a transparent and robust external peer-review process. A multifaceted training and outreach program includes individual training, workshops, summer schools, on-the-road, and support clinic segments by experienced scientific and technical staff. A Resource web portal provides streamlined scientific, technical, training, outreach and administrative material and other relevant information. A principal aim is to optimize and maintain, for reliable and forefront performance, experimental facilities and instrumentation, detectors, software and computing and network capabilities on the Resource’s 8+ beam lines at SSRL, capitalizing on the high SR x-ray performance of SSRL’s 3rd generation storage ring SPEAR3, and at the MFX station at LCLS. A multi-facility proposal mechanism facilitates access to complementary Cryo-EM and LCLS stations on-site at SLAC. With a specialized focus on user training, support and service, the Resource enables the scientific success for challenging and routine projects in the biomedical sciences.

摘要/摘要-P30GM133894 同步辐射(SR)是一种非常明亮和可调的X射线源，它使最前沿 结构分子生物学(SMB)研究。《同步加速器结构生物学》的目标 斯坦福大学同步辐射光源(SSRL)的资源，以下称为 简单地说，资源就是为用户提供对集成的、成熟的中小企业功能的访问 用于大分子结晶学的最先进的同步加速器束线设备 吸收/发射/成像光谱学和小角X射线散射/衍射。这些 三个领域构成了资源的三个技术运营核心。特别强调的是 创建简化的用户访问，提供专门的用户支持和服务，培训用户，以及 就这些专业但成熟的人的能力的科学益处进行外联 为生物医学研究社区提供设施。多种创新的接入机制是 这包括访问核心的单一技术方法和多技术方法， 基于透明和强有力的外部同行审查程序。多方面的培训和 外展计划包括个人培训、工作坊、暑期学校、在路上，以及 由经验丰富的科学和技术人员为诊所部门提供支持。资源门户网站 提供简化的科学、技术、培训、宣传和管理材料以及其他 相关信息。主要目标是优化和维护，以实现可靠和领先 性能、实验设施和仪器、探测器、软件和计算以及 资源在SSRL的8+束线上的网络功能，充分利用了高SR X射线 SSRL的第三代存储环SPEAR3的性能，以及在LCLS的MFX站。一个 多设施建议书机制便于获取互补的低温EM和LCLS 在SLAC的现场站点。专注于用户培训、支持和服务， 资源使生物医学领域具有挑战性的常规项目获得科学上的成功 科学。