Understanding The Impact of Diabetes on Implant Performance: A Retrieval Study
了解糖尿病对植入物性能的影响:一项检索研究
基本信息
- 批准号:10396771
- 负责人:
- 金额:$ 0.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-15 至 2023-05-14
- 项目状态:已结题
- 来源:
- 关键词:AddressAdhesionsAdverse effectsAffectAgeAlloysAreaBiologicalBiological FactorsBone TissueCell ProliferationCellsCharacteristicsChemicalsChromiumClinicalCobaltCorrosionDepositionDevicesDiabetes MellitusDiet HabitsDislocationsEnvironmentExposure toFailureFutureGenderGlucoseGoalsHabitsImageImmune responseImpaired wound healingImplantInfectionInflammationInflammatory ResponseInvestigationKetonesLeadLife StyleMetalsMicroscopicMicroscopyModificationMorphologyMotionNecrosisNutritionalOpticsOrthopedicsOsseointegrationOxidesPatientsPerformancePhysical activityPopulationPreparationProceduresPropertyProtocols documentationPublicationsRecording of previous eventsRetrievalRoentgen RaysSamplingScanning Electron MicroscopySeriesSmokingSpecimenSpectrum AnalysisSuccinatesSurfaceSurface PropertiesSurgeonTechniquesTestingTimeTissuesTitaniumUreaVisualX ray spectroscopybasebonebone healingcollagenasecombatdesigndiabeticdiabetic patientdiet and exercisedrinkinghealinghigh riskimmunoregulationimplant materialimprovedin vitro testinginterestmacrophagemetallicitynon-diabeticoxidationresponsesuccess
项目摘要
Proposal Summary and Abstract
Orthopedic devices have often been considered a higher risk to diabetic patients due to impaired wound
healing abilities that can be caused by reduced macrophages, collagenase, and cell proliferation. It is still not
well understood exactly which biological factors determine how effective bone healing is surrounding
orthopedic implants within diabetic conditions. This can have adverse effects on the success and performance
of the implant due to corrosion of the surface, micro motion, dislocation, infection or necrosis of the
surrounding tissues, or even surgeon error. In order to better determine how future implants can become
more successful in diabetic patients we would like to establish a correlation between the amount of decay of
the implant surface and the environment that the implant was exposed to. The overall goal of this study is to
understand surface properties, morphological features and failure modes of implants removed from diabetic
patients.
In summary, the implants received for analysis will be first subjected to optical microscopy to identify the
degree of biological and metallic products present on the surface. This technique will also enable identification
of areas with interesting features for further analysis. Then the implants will be ranked for the degree of visual
biological and metallic/wear deposition. Specimens will be subsequently subjected to a series of cleaning steps
following previous protocols developed in our group for surface preparation. Specimens will be again imaged
with optical microscopy, areas of interest will be marked and ranked for degree of biological and wear
products. Then specimens will be investigated with Scanning Electron Microscopy, followed by Energy
Dispersive X-ray Spectroscopy and X-ray Photoelectron Spectroscopy (XPS) for analysis of the chemical
composition and oxidation state, respectively, of surfaces. Following this, specimens will be subjected to
electrochemical testing for investigation of the corrosion properties of the materials. Immunomodulation may
be an important mechanism to improve osseous healing under compromised systemic conditions. Further
investigation is warranted of the surface characteristics that can modulate the inflammatory response to
promote osseous healing.
提案摘要及摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Alexandra Arteaga其他文献
Alexandra Arteaga的其他文献
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{{ truncateString('Alexandra Arteaga', 18)}}的其他基金
Understanding The Impact of Diabetes on Implant Performance: A Retrieval Study
了解糖尿病对植入物性能的影响:一项检索研究
- 批准号:
9760101 - 财政年份:2019
- 资助金额:
$ 0.25万 - 项目类别:
Understanding The Impact of Diabetes on Implant Performance: A Retrieval Study
了解糖尿病对植入物性能的影响:一项检索研究
- 批准号:
9926078 - 财政年份:2019
- 资助金额:
$ 0.25万 - 项目类别:
Understanding The Impact of Diabetes on Implant Performance: A Retrieval Study
了解糖尿病对植入物性能的影响:一项检索研究
- 批准号:
10397567 - 财政年份:2019
- 资助金额:
$ 0.25万 - 项目类别:
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