Multilevel Influences on HIV and Substance Use in a YMSM Cohort

雷达摘要： 这项雷达研究于2014年启动，旨在为艾滋病毒和艾滋病的风险和保护因素提供关键的见解 并查明促进者和障碍，以执行有效的战略，杜绝艾滋病毒 流行病。具体地说，雷达试图了解性传播感染之间的联系 (性传播感染)、物质使用和浪漫关系模式随时间的变化 男性(基督教青年会)和变性人女性。在我们最初的赠款期间，我们在以下方面非常有成效 关于招募、保留、科学产出和培养未来学者的问题。雷达招募了1200多名研究人员 参与者，并保持80%的保留率，自推出以来。到目前为止，有40多名科学家 出版物已经出版。雷达还作为创新研究的平台，拥有超过 通过NIDA C3PNO联盟进行的25项相关研究和7个概念。 该项目采用了多层次的研究设计，结合了生物学、二元性和网络组件 为艾滋病毒传播流行病学提供前所未有的视角。每隔一年对队列成员进行评估 六个月关于个人行为和风险；关系和性伴侣特征；以及社会，性， 和吸毒网络。成员还接受多项生物评估(药物和性传播感染检测以及 在每六个月的评估中)。雷达队列包括两名艾滋病毒阳性者 和阴性参与者，并继续建立艾滋病毒序列数据和生物谱系的储存库 从急性感染之前、期间和之后的时间点，可以促进未来的提案评估 物质使用、艾滋病毒风险、致病性和免疫力。

Radar Abstract: The RADAR study was launched in 2014 to provide critical insights into risk and protective factors for HIV and drug use and to identify facilitators and barriers to the implementation of an effective strategy to end the HIV epidemic. Specifically, RADAR seeks to understand the connections between sexually transmitted infections (STIs), substance use, and romantic relationship patterns over time among young men who have sex with men (YMSM) and transgender women. During our initial grant period, we were extremely productive in terms of recruitment, retention, scientific output, and training future scholars. RADAR recruited over 1,200 study participants and maintained a 80% retention rate since it was launched. To date, more than 40 scientific publications have been published. RADAR also served as a platform for innovative research, with more than 25 connected studies and seven concepts via the NIDA C3PNO consortium. The project utilizes a multilevel research design that incorporates biological, dyadic, and network components to provide an unprecedented view into HIV transmission epidemiology. Cohort members are assessed every six months on individual behavior and risk; relationship and sexual partner characteristics; and social, sexual, and drug-using networks. Members also receive multiple biological assessments (drug and STI testing and banking of plasma and DNA) at each six-month assessment. The RADAR cohort includes both HIV-positive and -negative participants, and it continues to build a repository of HIV sequence data and biospecimens from time points before, during, and after acute infection that can facilitate future proposals evaluating substance use, HIV risk, pathogenicity, and immunity.