Modeling of Acute Ischemic Stroke for Improving Mechanical Thrombectomy

急性缺血性中风建模以改善机械血栓切除术

• 批准号: 10399628
• 负责人: Francesco Costanzo
• 金额: $ 60.57万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-04 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10399628
• 关键词: Acute; Adhesions; Anatomy; Angiography; Biomechanics; Blood; Blood Chemical Analysis; Blood Platelets; Blood Vessels; Blood specimen; Cerebrovascular system; Cerebrum; Characteristics; Clinical; Clinical Data; Coagulation Process; Collagen; Complex; Computer Models; Data; Deposition; Development; Devices; Distal; Embolism; Endothelium; Excision; Experimental Models; Geometry; Glycerol; Growth; Hemostatic function; Histologic; In Vitro; Inferior vena cava structure; Ischemic Stroke; Knowledge; Lead; Measures; Mechanics; Methodology; Modeling; Modification; Operative Surgical Procedures; Outcome; Patient-Focused Outcomes; Patients; Performance; Periodicity; Physiological; Procedures; Process; Property; Public Health; Research; Silicones; Site; Stents; Surface; Surgical complication; Techniques; Technology; Testing; Therapeutic Embolization; Thrombectomy; Thrombosis; Thrombus; Time; United States; Water; X-Ray Computed Tomography; analog; base; cerebral artery; computer framework; hemodynamics; improved; in vivo; insight; mechanical properties; predictive modeling; stroke patient; success; technology/technique; tool; ultrasound; vascular injury

Summary For the estimated 700,000 acute ischemic strokes (AIS) that occur each year in the United States, new stent retriever devices have shown an increase in recanalization of occluded cerebral arteries. However, over 15% of thromboemboli are still unable to be cleared and another 17% of patients die within 90 days despite successful recanalization. To date, there is little understanding of the upstream thrombosis and embolization processes that lead to AIS and why some thromboemboli are successfully removed and others are not. To better understand the entire progression of AIS, we will develop computational models of the upstream thrombosis, thrombus embolization, lodging and adhesion in the cerebral vasculature, and removal via applied forces from a thrombectomy device. These models will be validated with ex vivo mock circulatory flow loops that enable real-time tracking of thrombus growth and embolization and for AIS occlusion to be simulated in physiologically accurate scenarios. Furthermore, patient-specific anatomy and blood chemistry will be used. The results of these studies will provide insight to AIS occlusion but provide an opportunity to improve overall patient outcomes.

总结