Modeling of Acute Ischemic Stroke for Improving Mechanical Thrombectomy
急性缺血性中风建模以改善机械血栓切除术
基本信息
- 批准号:9885461
- 负责人:
- 金额:$ 67.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-04 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdhesionsAnatomyAngiographyBiomechanicsBloodBlood Chemical AnalysisBlood PlateletsBlood VesselsBlood specimenCerebrovascular systemCerebrumCharacteristicsClinicalClinical DataCoagulation ProcessCollagenComplexComputer ModelsDataDepositionDevelopmentDevicesDistalEmbolismEndotheliumExcisionExperimental ModelsGeometryGlycerolGrowthHemostatic functionHistologicIn VitroInferior vena cava structureIschemic StrokeKnowledgeLeadMeasuresMechanicsMethodologyModelingModificationOperative Surgical ProceduresOutcomePatient-Focused OutcomesPatientsPerformancePeriodicityPhysiologicalProceduresProcessPropertyPublic HealthResearchSiliconesSiteStentsSurfaceSurgical complicationTechniquesTechnologyTestingTherapeutic EmbolizationThrombectomyThrombosisThrombusTimeUltrasonographyUnited StatesWaterX-Ray Computed Tomographyanalogbasecerebral arterycomputer frameworkhemodynamicsimprovedin vivoinsightmechanical propertiespredictive modelingstroke patientsuccesstechnology/techniquetoolvascular injury
项目摘要
Summary
For the estimated 700,000 acute ischemic strokes (AIS) that occur each year in the United States, new stent
retriever devices have shown an increase in recanalization of occluded cerebral arteries. However, over 15%
of thromboemboli are still unable to be cleared and another 17% of patients die within 90 days despite
successful recanalization. To date, there is little understanding of the upstream thrombosis and embolization
processes that lead to AIS and why some thromboemboli are successfully removed and others are not. To
better understand the entire progression of AIS, we will develop computational models of the upstream
thrombosis, thrombus embolization, lodging and adhesion in the cerebral vasculature, and removal via applied
forces from a thrombectomy device. These models will be validated with ex vivo mock circulatory flow loops
that enable real-time tracking of thrombus growth and embolization and for AIS occlusion to be simulated in
physiologically accurate scenarios. Furthermore, patient-specific anatomy and blood chemistry will be used.
The results of these studies will provide insight to AIS occlusion but provide an opportunity to improve overall
patient outcomes.
总结
对于美国每年发生的估计70万例急性缺血性卒中(AIS),
回收器装置已经显示出增加了闭塞的脑动脉的再通。然而,超过15%
的血栓栓塞仍然无法清除,另有17%的患者在90天内死亡,
成功再通。迄今为止,对上游血栓形成和栓塞的了解很少
导致AIS的过程以及为什么一些血栓栓塞被成功清除而另一些则没有。到
为了更好地了解AIS的整个进展,我们将开发上游的计算模型,
血栓形成、血栓栓塞、脑血管系统中的倒伏和粘连,以及通过应用
血栓切除器械的作用力。这些模型将使用离体模拟循环流动回路进行验证
这使得能够实时跟踪血栓生长和栓塞,并模拟AIS闭塞,
生理上准确的场景。此外,将使用患者特定解剖结构和血液化学。
这些研究的结果将为AIS闭塞提供深入了解,但也为总体改善提供了机会
患者结局。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Francesco Costanzo其他文献
Francesco Costanzo的其他文献
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{{ truncateString('Francesco Costanzo', 18)}}的其他基金
Modeling of Acute Ischemic Stroke for Improving Mechanical Thrombectomy
急性缺血性中风建模以改善机械血栓切除术
- 批准号:
10158507 - 财政年份:2020
- 资助金额:
$ 67.59万 - 项目类别:
Modeling of Acute Ischemic Stroke for Improving Mechanical Thrombectomy
急性缺血性中风建模以改善机械血栓切除术
- 批准号:
10399628 - 财政年份:2020
- 资助金额:
$ 67.59万 - 项目类别:
Modeling of Acute Ischemic Stroke for Improving Mechanical Thrombectomy
急性缺血性中风建模以改善机械血栓切除术
- 批准号:
10613506 - 财政年份:2020
- 资助金额:
$ 67.59万 - 项目类别:
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