Microbe-driven Development of GALT

微生物驱动的 GALT 开发

基本信息

  • 批准号:
    10399453
  • 负责人:
  • 金额:
    $ 46.18万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-05-25 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

Abstract Microbiota are required for the development of secondary lymphoid tissues, including gut- associated lymphoid tissues (GALT). Interactions between GALT and the microbiota are especially important in rabbits, as B cells proliferate and mutate their V(D)J genes in response to select commensal bacteria. Further, VHa B cells, identified because they utilize VH1, are selectively expanded in GALT as a result of specific commensal bacteria. In contrast, other B cells, designated VHn, do not expand in GALT. VHa and VHn B cells differ primarily in the external surface of framework regions (FR) 1 and 3, and we propose that VHa-specific amino acids on the external surfaces of FR1 and FR3 form a binding motif that together with TLR signaling through MyD88, mediates selective expansion of VHa B cells by binding bacterial cell surface molecules. We hypothesize that this innate-like, non-antigen-specific stimulation through the B cell receptor (BCR) facilitates selective expansion of VHa B cells and diversification of the primary Ab repertoire. In Aim 1, we will test this hypothesis by identifying bacteria in GALT that selectively bind to and activate VHa but not VHn B cells. Aim 2 will test if the identified bacteria specifically drive expansion of VHa B cells in vivo; and in Aim 3, we will explore the mechanism by which the bacteria stimulate VHa B cells. The results will elucidate a new mechanism by which bacteria interact with B cells to promote development of the immune system.
摘要

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Death of tonsillar B cells by NETosis.
  • DOI:
    10.1038/s41420-023-01402-4
  • 发表时间:
    2023-03-30
  • 期刊:
  • 影响因子:
    7
  • 作者:
    Bukhari A;Kalinina O;Knight KL
  • 通讯作者:
    Knight KL
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Katherine L. Knight其他文献

Genetic control of alpha chains of rabbit IgA: allotypic specificities on the variable and the constant regions.
兔 IgA α 链的遗传控制:可变区和恒定区的同种异型特异性。
Exopolysaccharide-treated Dendritic Cells Effectively Ameliorate Acute Graft vs Host Disease.
胞外多糖处理的树突状细胞可有效改善急性移植物抗宿主病。
  • DOI:
    10.1016/j.jtct.2023.10.023
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    O. Kalinina;L. Minter;Anne I. Sperling;M. K. Hollinger;Phong Le;Barbara A. Osborne;Shubin Zhang;Patrick Stiff;Katherine L. Knight
  • 通讯作者:
    Katherine L. Knight
Identification and genetic control of two rabbit high-density lipoprotein allotypes
  • DOI:
    10.1007/bf00486087
  • 发表时间:
    1972-10-01
  • 期刊:
  • 影响因子:
    1.600
  • 作者:
    Alice Gilman-Sachs;Katherine L. Knight
  • 通讯作者:
    Katherine L. Knight
Intestinal bacteria and development of the B-lymphocyte repertoire
  • DOI:
    10.1016/j.it.2005.06.001
  • 发表时间:
    2005-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Dennis K. Lanning;Ki-Jong Rhee;Katherine L. Knight
  • 通讯作者:
    Katherine L. Knight
Contribution of the allelicMtz 3 andMtz 4 allotype genes to the formation of individual rabbit serum α2-macroglobulin molecules
  • DOI:
    10.1007/bf00486080
  • 发表时间:
    1972-10-01
  • 期刊:
  • 影响因子:
    1.600
  • 作者:
    Bernard H. Berne;Sheldon Dray;Katherine L. Knight
  • 通讯作者:
    Katherine L. Knight

Katherine L. Knight的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Katherine L. Knight', 18)}}的其他基金

Development of a mucosal vaccine to prevent Clostridium difficile infection using papilloma pseudovirus as a vector.
使用乳头状瘤假病毒作为载体开发粘膜疫苗以预防艰难梭菌感染。
  • 批准号:
    10213890
  • 财政年份:
    2020
  • 资助金额:
    $ 46.18万
  • 项目类别:
Prevention of GVHD by a probiotic exopolysaccharide.
通过益生菌胞外多糖预防 GVHD。
  • 批准号:
    10081555
  • 财政年份:
    2020
  • 资助金额:
    $ 46.18万
  • 项目类别:
Microbe-driven Development of GALT
微生物驱动的 GALT 开发
  • 批准号:
    9924442
  • 财政年份:
    2018
  • 资助金额:
    $ 46.18万
  • 项目类别:
Commensal Exopolysaccharide Protection from Inflammation
共生胞外多糖预防炎症
  • 批准号:
    8888736
  • 财政年份:
    2015
  • 资助金额:
    $ 46.18万
  • 项目类别:
Protection from enteric pathogens by beneficial microbes
通过有益微生物预防肠道病原体
  • 批准号:
    8546976
  • 财政年份:
    2012
  • 资助金额:
    $ 46.18万
  • 项目类别:
Protection from enteric pathogens by beneficial microbes
通过有益微生物预防肠道病原体
  • 批准号:
    8256331
  • 财政年份:
    2012
  • 资助金额:
    $ 46.18万
  • 项目类别:
Somatic Diversification of Immunoglobulin Genes in Galt
Galt 免疫球蛋白基因的体细胞多样化
  • 批准号:
    8321129
  • 财政年份:
    2011
  • 资助金额:
    $ 46.18万
  • 项目类别:
Maintaining B cell immunity with aged B lymphocytes
用老化的 B 淋巴细胞维持 B 细胞免疫
  • 批准号:
    7878421
  • 财政年份:
    2009
  • 资助金额:
    $ 46.18万
  • 项目类别:
Maintaining B cell immunity with aged B lymphocytes
用老化的 B 淋巴细胞维持 B 细胞免疫
  • 批准号:
    8015990
  • 财政年份:
    2007
  • 资助金额:
    $ 46.18万
  • 项目类别:
Maintaining B cell immunity with aged B lymphocytes
用老化的 B 淋巴细胞维持 B 细胞免疫
  • 批准号:
    7365169
  • 财政年份:
    2007
  • 资助金额:
    $ 46.18万
  • 项目类别:

相似海外基金

Double Incorporation of Non-Canonical Amino Acids in an Animal and its Application for Precise and Independent Optical Control of Two Target Genes
动物体内非规范氨基酸的双重掺入及其在两个靶基因精确独立光学控制中的应用
  • 批准号:
    BB/Y006380/1
  • 财政年份:
    2024
  • 资助金额:
    $ 46.18万
  • 项目类别:
    Research Grant
Quantifying L-amino acids in Ryugu to constrain the source of L-amino acids in life on Earth
量化 Ryugu 中的 L-氨基酸以限制地球生命中 L-氨基酸的来源
  • 批准号:
    24K17112
  • 财政年份:
    2024
  • 资助金额:
    $ 46.18万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Molecular recognition and enantioselective reaction of amino acids
氨基酸的分子识别和对映选择性反应
  • 批准号:
    23K04668
  • 财政年份:
    2023
  • 资助金额:
    $ 46.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Basic research toward therapeutic strategies for stress-induced chronic pain with non-natural amino acids
非天然氨基酸治疗应激性慢性疼痛策略的基础研究
  • 批准号:
    23K06918
  • 财政年份:
    2023
  • 资助金额:
    $ 46.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molecular mechanisms how arrestins that modulate localization of glucose transporters are phosphorylated in response to amino acids
调节葡萄糖转运蛋白定位的抑制蛋白如何响应氨基酸而被磷酸化的分子机制
  • 批准号:
    23K05758
  • 财政年份:
    2023
  • 资助金额:
    $ 46.18万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Design and Synthesis of Fluorescent Amino Acids: Novel Tools for Biological Imaging
荧光氨基酸的设计与合成:生物成像的新工具
  • 批准号:
    2888395
  • 财政年份:
    2023
  • 资助金额:
    $ 46.18万
  • 项目类别:
    Studentship
Collaborative Research: RUI: Elucidating Design Rules for non-NRPS Incorporation of Amino Acids on Polyketide Scaffolds
合作研究:RUI:阐明聚酮化合物支架上非 NRPS 氨基酸掺入的设计规则
  • 批准号:
    2300890
  • 财政年份:
    2023
  • 资助金额:
    $ 46.18万
  • 项目类别:
    Continuing Grant
Structurally engineered N-acyl amino acids for the treatment of NASH
用于治疗 NASH 的结构工程 N-酰基氨基酸
  • 批准号:
    10761044
  • 财政年份:
    2023
  • 资助金额:
    $ 46.18万
  • 项目类别:
Lifestyle, branched-chain amino acids, and cardiovascular risk factors: a randomized trial
生活方式、支链氨基酸和心血管危险因素:一项随机试验
  • 批准号:
    10728925
  • 财政年份:
    2023
  • 资助金额:
    $ 46.18万
  • 项目类别:
Single-molecule protein sequencing by barcoding of N-terminal amino acids
通过 N 端氨基酸条形码进行单分子蛋白质测序
  • 批准号:
    10757309
  • 财政年份:
    2023
  • 资助金额:
    $ 46.18万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了