Hypertensive Disorders of Pregnancy and Subsequent Risk of Vascular Dementia, Alzheimer's Disease, or Related Dementia: A Retrospective Cohort Study Taking into Account Mid-Life Mediating Factors.

妊娠期高血压疾病和随后的血管性痴呆、阿尔茨海默氏病或​​相关痴呆的风险：一项考虑中年中介因素的回顾性队列研究。

• 批准号: 10401478
• 负责人: Karen C. Schliep
• 金额: $ 12.15万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10401478
• 关键词: Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease care; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American; Applications Grants; Area; Award; Blood Vessels; Chronic Disease; Classification; Clinical; Cognitive; Cohort Studies; County; Data; Data Analyses; Data Set; Databases; Dementia; Diagnosis; Eclampsia; Elderly; Epidemiology; Etiology; Family; Fertility; Fostering; Frontotemporal Dementia; Future; Goals; Gold; Health; Health Status; Hypertension; Image; Individual; Inflammatory; International; Intervention; Knowledge; Lead; Lewy Body Dementia; Life Cycle Stages; Life course epidemiology; Link; Longevity; Maternal-fetal medicine; Mediating; Medical; Medical Records; Memory; Menopause; Mental Depression; Mentored Research Scientist Development Award; Mentors; Methods; Modeling; Neurologic; Neurological outcome; Neurologist; Neuropsychology; Outcome; Patients; Population; Population Database; Population Research; Population Study; Positioning Attribute; Pre-Eclampsia; Pregnancy; Pregnancy Complications; Prevalence; Principal Investigator; Psychosocial Factor; Public Health; Recording of previous events; Records; Reproductive Health; Research; Research Methodology; Research Personnel; Retrospective Studies; Retrospective cohort study; Risk; Risk Factors; Sensitivity and Specificity; Sex Differences; Social Environment; Testing; Training; Universities; Utah; Validation; Vascular Dementia; Woman; Women' s Health; administrative database; aging population; base; biomedical informatics; career; clinical diagnostics; cohort; comorbidity; cost; dementia risk; epidemiology study; experience; family genetics; health assessment; health difference; high risk; hypertension treatment; hypertensive; improved; improved outcome; lifetime risk; machine learning model; machine learning prediction; men; middle age; mortality risk; normotensive; novel; population based; pregnancy disorder; pregnancy hypertension; prevent; professor; programs; prospective; reproductive; reproductive system disorder; sex; skills; sociodemographics

PROJECT SUMMARY/ABSTRACT This is an application for a K01 award for Dr. Karen Schliep, a tenure-line Assistant Professor of Public Health at the University of Utah. Dr. Schliep is establishing herself as a young investigator in women’s life-course epidemiology, specifically in a novel area of aging research—to improve our understanding of women’s increased risk of Alzheimer’s disease (AD) and related dementias (RD) and create women-specific interventions to mitigate risk and improve outcomes. This award will allow Dr. Schliep to achieve her goal of research independence by providing her support to accomplish the following training aims: 1) develop expertise in biomedical informatics and population-based research methods; 2) gain experience in the conduction of clinical cognitive health assessments; 3) enhance knowledge of modifiable factors affecting women’s mid- and late-life cognitive health; and 4) expand skills to independently lead and manage a successful research program. Dr. Schliep has assembled a mentoring team comprising a primary mentor, Dr. Michael Varner, an obstetrician and nationally renowned maternal-fetal medicine investigator with expertise in pregnancy complications including hypertensive disorders of pregnancy (HDP), and two co-mentors: Dr. Norman Foster, a cognitive neurologist and geriatric neurologist and recognized leader in dementia research, and Dr. Ken Smith, an internationally known expert in population-based analyses and genetic/family epidemiology. Dr. Schliep has five advisors with expertise in classification modeling, ADRD neuropsychology, mid-life women’s health, longitudinal and survival data analysis, and chronic disease epidemiology. Little is known regarding the association between HDP, estimated to complicate 2–8% of all pregnancies, and long-term adverse maternal neurological outcomes with similar inflammatory vascular etiologies, including ADRD. An estimated 5.4 million Americans currently suffer from ADRD, two-thirds of whom are women. As the US aging population increases, prevalence of dementia is expected to approach 13.2 to 16.0 million cases by 2050. Why ADRD disproportionately affects women is not known. Dr. Schliep’s research objective is to develop classification models for the various dementia subtypes (including AD, vascular dementia, Lewy body dementia, and frontotemporal dementia) to analyze longitudinal, individual-level data to better understand how HDP may increase a woman’s risk for ADRD. Dr. Schliep will accomplish this through the following research aims: 1) increase accuracy of ADRD diagnoses within health administrative databases; and 2) investigate the association between HDP and ADRD, and mid-life mediating factors. The proposal’s expected outcomes include 1) a novel method to accurately capture dementia cases within large linked health administrative databases; 2) clarity on how HDP may be linked with specific dementia subtypes; and 3) skills, experience, and preliminary data for Dr. Schliep to support future studies identifying other sex-specific risk factors for dementia and mediating factors amenable to interventions.

项目总结/文摘