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Precision Mapping the Human Cerebellum for Neuromodulation and Understanding of Brain Disorders

精确绘制人类小脑的神经调节和理解脑部疾病

基本信息

批准号：
10400877
负责人：
RANDY L BUCKNER
金额：
$ 57.31万
依托单位：
HARVARD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10400877
关键词：
Address Anatomy Area Attention deficit hyperactivity disorder Biological Brain Brain Diseases Cerebellar Diseases Cerebellum Cerebral cortex Cerebrum Cognition Cognitive Communities Complex Data Development Emotions Foundations Future Goals Human Image Individual Intervention Island Language Link Lobule Magnetic Resonance Imaging Maps Mental Health Mental disorders Methods Modeling Motor Neuroanatomy Participant Pathway interactions Patient Care Patients Persons Positioning Attribute Reporting Research Resolution Scanning Schizophrenia Site Statistical Models Structure Symptoms Testing Time Visual Work autism spectrum disorder cerebellar lesion cognitive control cognitive function cranium expectation extrastriate improved innovation insight magnetic field millimeter neuroimaging neuropsychiatric disorder neuropsychiatry neuroregulation next generation nonhuman primate novel novel therapeutic intervention preservation response retinotopic social targeted treatment

项目摘要

PROJECT ABSTRACT/SUMMARY The cerebellum is the second largest structure in the human brain. Until recently, the cerebellum was considered solely a motor structure. Discoveries from neuroanatomy, study of patients with cerebellar lesions, and human neuroimaging have all converged to suggest that major zones of the cerebellum participate in advanced forms of cognition. Relevant to mental health, cerebellar dysfunction has been implicated in psychiatric illness and preliminary reports suggest noninvasive stimulation of the cerebellum may benefit symptoms in schizophrenia. However our detailed understanding of cerebellar organization is far behind that of the cerebral cortex, leading to debates about the spatial organization of cerebellar zones linked to human thought and emotion, and even debate about the degree to which the functional organization of the cerebellum is consistent from one person to the next. The goal of the present work is to provide a detailed understanding of cerebellar organization with particular focus on zones implicated in higher-order cognition that include regions accessible to neuromodulation. (1) First, advanced human high-field MRI methods will be used to map networks across the cerebellum fully within individuals preserving the anatomical details that would otherwise be lost with lower resolution approaches or by averaging findings across individuals. To achieve this level of precision each individual will be imaged repeatedly. (2) Second, to establish that the spatially separate regions of the cerebellum are functionally distinct, the same individuals will be administered challenging tasks that probe language, social, and memorial functions to rigorously establish separation between cerebellar zones that may be as little as a few millimeters apart. (3) Enabled by the precision maps of cerebellar organization, open debates will be resolved that include questions about how many times high-order cognitive zones repeat across the cerebellum and whether small, difficult to map, isolated zones of function contribute to the uniqueness of each person’s brain. (4) Critical to the long-term objective of this work to benefit patient care, the precision maps of each individual’s cerebellum will be used to model the possible effects of non-invasive stimulation. In doing so, a path from precision mapping of the cerebellum to neuromodulation will be provided openly as well as high-resolution maps and raw data that can be utilized by the community to further improve available methods for neuromodulation. Most broadly, the present work seeks to better understand the detailed organization of the human cerebellum to serve as a foundation for understanding and further developing novel interventions in the battle against mental illness.

项目摘要/总结

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Specialization of the Human Hippocampal Long Axis Revisited.

重新审视人类海马长轴的专业化。

DOI：
10.1101/2023.12.19.572264
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Angeli,PeterA;DiNicola,LaurenM;Saadon-Grosman,Noam;Eldaief,MarkC;Buckner,RandyL
通讯作者：
Buckner,RandyL

High-resolution fMRI at 7 Tesla: challenges, promises and recent developments for individual-focused fMRI studies.

DOI：
10.1016/j.cobeha.2021.01.011
发表时间：
2021-08
期刊：
Current opinion in behavioral sciences
影响因子：
5
作者：
Viessmann O;Polimeni JR
通讯作者：
Polimeni JR

Human Striatal Association Megaclusters.

人类纹状体协会巨团。

DOI：
10.1101/2023.10.03.560666
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Kosakowski,HeatherL;Saadon-Grosman,Noam;Du,Jingnan;Eldaief,MarkE;Buckner,RandyL
通讯作者：
Buckner,RandyL

Slice-direction geometric distortion evaluation and correction with reversed slice-select gradient acquisitions.

DOI：
10.1016/j.neuroimage.2022.119701
发表时间：
2022-12-01
期刊：
NEUROIMAGE
影响因子：
5.7
作者：
Blazejewska, Anna, I;Witzel, Thomas;Andersson, Jesper L. R.;Wald, Lawrence L.;Polimeni, Jonathan R.
通讯作者：
Polimeni, Jonathan R.

Functional specialization of parallel distributed networks revealed by analysis of trial-to-trial variation in processing demands.