Exploration of MRI measures of neurodegeneration within individuals over short intervals
Exploration of MRI measures of neurodegeneration within individuals over short intervals
批准号:
10605237
负责人:
RANDY L BUCKNER
金额:
$67.4万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-04-15 至 2025-03-31
关键词:
AccelerationAchievementAffectAgeAgingAlzheimer&aposs DiseaseAmericanAmyloid beta-ProteinAnatomyAtrophicBase SequenceBiological MarkersBrainBrain imagingBrain regionBrain scanClinicClinicalClinical TrialsClinical assessmentsDataDementiaDevelopmentDiagnosisDiseaseDisease ProgressionEarly identificationEventFocus GroupsGoalsHeadHippocampusHumanImaging TechniquesImpaired cognitionIndividualJointsMRI ScansMachine LearningMagnetic Resonance ImagingMeasurementMeasuresMedical ResearchMemory impairmentMethodologyModelingMonitorNerve DegenerationNeurosciences ResearchPathologyPatternPersonsPhasePositioning AttributePrimary Progressive AphasiaProceduresProgressive AphasiasProtocols documentationProxyResearchResolutionSafetySamplingScanningSemanticsStatistical ModelsStreamStructureTechniquesTestingTherapeutic EffectThickTimeUnmarried personVariantWorkamnestic mild cognitive impairmentbrain volumecerebral atrophyclinical translationcognitive changehippocampal atrophyimage reconstructionimaging approachmorphometryneuroimagingnormal agingnovelpre-clinicalrate of changesafety testingsecondary analysisstructural imagingtau Proteinstherapeutic developmenttime intervaltooltreatment response
中文摘要
项目摘要/总结
英文摘要
PROJECT ABSTRACT/SUMMARY
Alzheimer's disease and other forms of dementia affect over five million Americans. Alzheimer's disease
begins with changes in the brain more than a decade before the disease can be diagnosed from memory and
cognitive impairment in a clinic. The goal of this work is to provide a way to measure early signs of
neurodegeneration in individual people. The historical barrier to measure change in individuals is that each
person's brain is different with change accumulating too slowly to be picked over short intervals. As a result,
most research focuses on tracking averaged subject groups or tracking change over multiple years. The
present work optimizes new brain imaging techniques using MRI to make extremely fast, highly precise
repeated measurements of brain regions all within the same individual. The work then seeks to use the novel
imaging approach to measure neurodegeneration in individuals with early stages of Alzheimer's disease in six
months or less and also differentiate changes in people with Alzheimer's disease from less common forms of
dementia that have distinct anatomical changes in the brain. If successful, the present work will provide a new
means to track the early stages of neurodegeneration as would be used in clinical trials and translational
medical research.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Precision Mapping the Human Cerebellum for Neuromodulation and Understanding of Brain Disorders
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批准号:10400877
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项目类别:
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资助金额:$57.31万
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财政年份:2020
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负责人:RANDY L BUCKNER
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依托单位:
Exploration of MRI measures of neurodegeneration within individuals over short intervals
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批准号:10378583
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项目类别:
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资助金额:$69.51万
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财政年份:2020
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负责人:RANDY L BUCKNER
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依托单位:
Precision Mapping the Human Cerebellum for Neuromodulation and Understanding of Brain Disorders
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批准号:10028768
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项目类别:
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资助金额:$60.87万
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财政年份:2020
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负责人:RANDY L BUCKNER
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依托单位:
Translational Neuroscience Training for Clinicians
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批准号:10202393
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项目类别:
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资助金额:$40.11万
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财政年份:2018
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负责人:RANDY L BUCKNER
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依托单位:
Translational Neuroscience Training for Clinicians
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批准号:9905553
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项目类别:
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资助金额:$40.66万
-
财政年份:2018
-
负责人:RANDY L BUCKNER
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依托单位:
Translational Neuroscience Training for Clinicians
-
批准号:10401433
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项目类别:
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资助金额:$42.58万
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财政年份:2018
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负责人:RANDY L BUCKNER
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依托单位:
Upgrade Siemens MAGNETOM Trio to MAGNETOM Prisma Fit 3T Human MRI System
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批准号:8825137
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项目类别:
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资助金额:$60.0万
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财政年份:2015
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负责人:RANDY L BUCKNER
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依托单位:
Neural and Genetic Basis of Negative Valance Traits
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批准号:8573627
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项目类别:
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资助金额:$69.14万
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财政年份:2013
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负责人:RANDY L BUCKNER
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依托单位:
Neural and Genetic Basis of Negative Valance Traits
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批准号:8735195
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项目类别:
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资助金额:$69.55万
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财政年份:2013
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负责人:RANDY L BUCKNER
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依托单位:
Neural and Genetic Basis of Negative Valance Traits
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批准号:9100922
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项目类别:
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资助金额:$53.21万
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财政年份:2013
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负责人:RANDY L BUCKNER
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依托单位:
Neural Processes Underlying Cognitive Aging
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批准号:8523721
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项目类别:
-
资助金额:$49.16万
-
财政年份:2009
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负责人:RANDY L BUCKNER
-
依托单位:
Neural Processes Underlying Cognitive Aging
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批准号:8316217
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项目类别:
-
资助金额:$52.72万
-
财政年份:2009
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负责人:RANDY L BUCKNER
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依托单位:
Neural Processes Underlying Cognitive Aging
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批准号:7929455
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项目类别:
-
资助金额:$54.73万
-
财政年份:2009
-
负责人:RANDY L BUCKNER
-
依托单位:
Neural Processes Underlying Cognitive Aging
-
批准号:8132927
-
项目类别:
-
资助金额:$54.0万
-
财政年份:2009
-
负责人:RANDY L BUCKNER
-
依托单位:
Neural Processes Underlying Cognitive Aging
-
批准号:7728616
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项目类别:
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资助金额:$55.28万
-
财政年份:2009
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负责人:RANDY L BUCKNER
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依托单位:
Functional-anatomic exploration of cognitive control
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批准号:6872599
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项目类别:
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资助金额:$25.83万
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财政年份:2005
-
负责人:RANDY L BUCKNER
-
依托单位:
Functional-anatomic exploration of cognitive control
-
批准号:7279227
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项目类别:
-
资助金额:$24.49万
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财政年份:2005
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负责人:RANDY L BUCKNER
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依托单位:
Functional-anatomic exploration of cognitive control
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批准号:7407396
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项目类别:
-
资助金额:$24.0万
-
财政年份:2005
-
负责人:RANDY L BUCKNER
-
依托单位:
Functional-anatomic exploration of cognitive control
-
批准号:7887510
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项目类别:
-
资助金额:$24.0万
-
财政年份:2005
-
负责人:RANDY L BUCKNER
-
依托单位:
Functional-anatomic exploration of cognitive control
-
批准号:7021415
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项目类别:
-
资助金额:$25.22万
-
财政年份:2005
-
负责人:RANDY L BUCKNER
-
依托单位:
海外基金