Combined Transcranial Direct Current Stimulation and Virtual Reality for PTSD
Combined Transcranial Direct Current Stimulation and Virtual Reality for PTSD
批准号:
10401243
负责人:
Noah Stephen Philip
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-04-01 至 2023-03-31
关键词:
AddressAmygdaloid structureAreaBrainBrain regionChronicChronic Post Traumatic Stress DisorderClinicalCoupledCuesDataDevicesEnvironmentEvaluationExposure toFamilyFreedomFrightFunctional Magnetic Resonance ImagingGalvanic Skin ResponseGenerationsGoalsHealthInterventionKnowledgeLearningMeasuresMedicalMemoryMental disordersMissionModelingNeurobiologyNeuronsNeurosciencesOccupationalOutcomePathologicPost-Traumatic Stress DisordersPrefrontal CortexPrevalenceProceduresProcessPsychophysiologyPsychotherapyPublic HealthQuality of lifeRandomizedRandomized Controlled TrialsRegimenRegulationRehabilitation therapyResearchRestRodent ModelSafetySeveritiesSocial WorkSocietiesStandardizationStimulusSymptomsTechnologyTestingTherapeuticTraumaTreatment EffectivenessVeteransWorkadaptive learningbaseclinical applicationcomorbiditydesignefficacy evaluationefficacy testingevidence baseexperiencefunctional outcomeshabituationhealthy volunteerimplementation researchimprovedimproved outcomeinnovationneural circuitneuroimagingneuropsychiatryneuroregulationnoninvasive brain stimulationnovelnovel strategiesoperationpreventprospectiverandomized controlled studyreduce symptomsresponsesham-controlled studysocialsocial deficitsstress related disordersuccesstrauma exposurevirtual realityvirtual reality exposure
中文摘要
创伤后应激障碍(PTSD)是一种非常普遍的慢性精神障碍,它会给患者带来严重的精神疾病
英文摘要
Posttraumatic Stress Disorder (PTSD) is a highly prevalent, chronic psychiatric disorder that imposes a
major health burden on our returning Veterans. Moreover, PTSD is associated with marked occupational and
social dysfunction, and high degrees of psychiatric and medical comorbidity. Despite its prevalence and
devastating impact, available treatments, including evidence-based psychotherapy, are not sufficiently
efficacious. Therefore, innovative interventions for the treatment of PTSD are sorely needed for Veterans
suffering from PTSD.
The application of non-invasive neuromodulation technologies is developing rapidly across neuro-
psychiatry. The availability of new devices, coupled with increased knowledge of underlying neurocircuitry
relevant to psychiatric illness, sets the stage for economically advantageous and innovative clinical applications
of technologies for PTSD rehabilitation. Furthermore, rodent models and our previous pilot research indicate
the therapeutic potential for combining non-invasive brain stimulation with exposure for PTSD. However to
determine the real-world utility of combining brain stimulation with exposure, it is essential to examine how
this combination reduces PTSD symptoms and improves quality of life or social and occupational function
(QOL/SOF).
The aim of the proposed research is to examine whether non-invasive brain stimulation can be
combined with standardized, virtual-reality (VR) based exposure as an intervention for PTSD in Veterans. This
study will use transcranial direct current stimulation (tDCS) targeting brain regions involved in PTSD, with
stimulation delivered during VR. tDCS+VR holds particular promise for PTSD as this combination leverages
the potential efficacy of both interventions, and provides a standardized exposure regimen that can be
systemically evaluated. This application builds on our pilot work, demonstrating the technical feasibility of
tDCS+VR, by proposing an adequately powered, randomized controlled trial of tDCS+VR in which 90 Veterans
with PTSD will be randomized to receive either active tDCS or sham during VR. Three Specific Aims will be
evaluated: 1) Prospectively examine the efficacy of tDCS+VR in Veterans with chronic PTSD, 2) Examine the
relationship between PTSD-related psychophysiology, PTSD symptoms and QOL/SOF, and 3) Explore the
relationship between changes in neural circuitry, PTSD and QOL/SOF. Addressing these Aims will provide the
necessary data and experience to guide implementation research of tDCS+VR to reduce PTSD symptoms and
improve QOL/SOF. Ultimately, this line of research can be expected to have an important positive impact
toward achieving our long-term goal of integrating neuromodulation into PTSD treatment as a valuable,
practical, and accessible option to improve the lives of our Veterans.
!
!
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
Low intensity focused ultrasound: a new paradigm for depression and anxiety
-
批准号:10209047
-
项目类别:
-
资助金额:$61.05万
-
财政年份:2021
-
负责人:Noah Stephen Philip
-
依托单位:
Low intensity focused ultrasound: a new paradigm for depression and anxiety
-
批准号:10414943
-
项目类别:
-
资助金额:$58.31万
-
财政年份:2021
-
负责人:Noah Stephen Philip
-
依托单位:
Low intensity focused ultrasound: a new paradigm for depression and anxiety
-
批准号:10612008
-
项目类别:
-
资助金额:$58.53万
-
财政年份:2021
-
负责人:Noah Stephen Philip
-
依托单位:
Combined Transcranial Magnetic Stimulation and Brief Cognitive Therapy to Reduce Veteran Suicide
-
批准号:10209958
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Noah Stephen Philip
-
依托单位:
ShEEP Request to Acquire Brainsonix Advanced Focused Ultrasound System
-
批准号:9794295
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2019
-
负责人:Noah Stephen Philip
-
依托单位:
Pilot Testing of Theta-Burst Neuromodulation for Chronic PTSD
-
批准号:9250637
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2016
-
负责人:Noah Stephen Philip
-
依托单位:
PTSD and the Default Network: Developing Imaging Phenotypes
-
批准号:8669727
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2013
-
负责人:Noah Stephen Philip
-
依托单位:
PTSD and the Default Network: Developing Imaging Phenotypes
-
批准号:8540740
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2013
-
负责人:Noah Stephen Philip
-
依托单位:
PTSD and the Default Network: Developing Imaging Phenotypes
-
批准号:9336820
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2013
-
负责人:Noah Stephen Philip
-
依托单位: