ShEEP Request to Acquire Brainsonix Advanced Focused Ultrasound System

严重抑郁症、创伤后应激障碍和中风影响着数百万人， 退伍军人每年每一种情况都与严重的损伤有关 在心理社会功能上。此外，现有的治疗方法具有适度的疗效， 与普通人群相比，退伍军人的结果更差，强调了 需要开发创新的新疗法。VA RR&D神经修复中心 和神经技术（CfNN）是普罗维登斯VAMC， 布朗大学、巴特勒医院、Lifespan和马萨诸塞州总医院， 将研究人员和临床医生团结在一起， 神经技术来恢复失去的功能。通过此次共享设备评估 计划申请，我们打算购买Brainsonix聚焦超声系统。 该设备将为VA研究人员开发下一代大脑提供 刺激研究;目前的技术仅依赖于电磁刺激， 从而限制了它们直接刺激与抑郁有关的大脑区域的能力， 创伤后应激障碍和中风。因此，该设备将用于CfNN研究的新推力， 开发，测试和翻译新的神经技术，以促进康复 对于退伍军人。 该设备的主要用途包括（1）测试和部署聚焦超声 改善抑郁症（菲利普博士），（2）开发聚焦超声作为一种新的 治疗直接刺激涉及PTSD的脑深部区域（Shea博士），以及（3） 使用聚焦超声增强神经康复的退伍军人与上 中风导致的四肢无力（Hochberg博士）。获得该设备的支持将 能够收集新的数据，整合和进一步合作，围绕现有的 在CfNN的神经技术，并直接促进新技术的发展 用于VHA系统内的神经修复。

Major depression, posttraumatic stress disorder (PTSD) and stroke affect millions of Veterans every year. Each of these conditions is associated with significant impairments in psychosocial function. Furthermore, existing treatments have modest efficacy, with even poorer outcomes in Veterans compared to the general population, underscoring the need to develop innovative new treatments. The VA RR&D Center for Neurorestoration and Neurotechnology (CfNN) is a unique collaboration between Providence VAMC, Brown University, Butler Hospital, Lifespan, and Massachusetts General Hospital that unifies researchers and clinicians with the goal of advancing and translating neurotechnology to restore lost function. Through this Shared Equipment Evaluation Program application, we intend to purchase a Brainsonix focused ultrasound system. This device will provide VA researchers to develop the next generation of brain stimulation research; current technologies rely solely upon electromagnetic stimulation, thus limiting their ability to directly stimulate brain regions involved in depression, PTSD and stroke. Thus, this device would be used in a new thrust of CfNN research to develop, test, and translate novel neurotechnologies in order to facilitate rehabilitation for Veterans. Major uses of the device would include (1) testing and deployment of focused ultrasound to improve major depression (Dr. Philip), (2) developing focused ultrasound as a novel treatment to directly stimulate deep brain regions involved in PTSD (Dr. Shea), and (3) using focused ultrasound-enhanced neurorehabilitation for Veterans with upper extremity weakness due to stroke (Dr. Hochberg). Support to obtain this device would enable the collection of novel data, integrate and further collaboration around existing neurotechnologies at CfNN, and directly facilitate the development of novel technologies for Neurorestoration within the VHA System.