ShEEP Request to Acquire Brainsonix Advanced Focused Ultrasound System

ShEEP 请求收购 Brainsonix 高级聚焦超声系统

• 批准号: 9794295
• 负责人: Noah Stephen Philip
• 金额: --
• 依托单位: PROVIDENCE VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9794295
• 关键词: Affect; Area; Brain; Brain region; Collaborations; Collection; Data; Development; Devices; Electromagnetics; Equipment; Focused Ultrasound; General Hospitals; General Population; Goals; Health; Hospitals; Impairment; Investigation; Longevity; Major Depressive Disorder; Massachusetts; Mental Depression; Neurorehabilitation; Outcome; Post-Traumatic Stress Disorders; Program Evaluation; Psychiatrist; Recovery; Recovery of Function; Rehabilitation therapy; Research; Research Personnel; Sheep; Stroke; System; Technology; Testing; Translating; Universities; Upper Extremity; Veterans; functional outcomes; functional restoration; improved; innovation; insight; neuropsychiatric disorder; neuropsychiatry; neurorestoration; neurotechnology; new technology; next generation; novel; programs; psychosocial; research and development

Major depression, posttraumatic stress disorder (PTSD) and stroke affect millions of Veterans every year. Each of these conditions is associated with significant impairments in psychosocial function. Furthermore, existing treatments have modest efficacy, with even poorer outcomes in Veterans compared to the general population, underscoring the need to develop innovative new treatments. The VA RR&D Center for Neurorestoration and Neurotechnology (CfNN) is a unique collaboration between Providence VAMC, Brown University, Butler Hospital, Lifespan, and Massachusetts General Hospital that unifies researchers and clinicians with the goal of advancing and translating neurotechnology to restore lost function. Through this Shared Equipment Evaluation Program application, we intend to purchase a Brainsonix focused ultrasound system. This device will provide VA researchers to develop the next generation of brain stimulation research; current technologies rely solely upon electromagnetic stimulation, thus limiting their ability to directly stimulate brain regions involved in depression, PTSD and stroke. Thus, this device would be used in a new thrust of CfNN research to develop, test, and translate novel neurotechnologies in order to facilitate rehabilitation for Veterans. Major uses of the device would include (1) testing and deployment of focused ultrasound to improve major depression (Dr. Philip), (2) developing focused ultrasound as a novel treatment to directly stimulate deep brain regions involved in PTSD (Dr. Shea), and (3) using focused ultrasound-enhanced neurorehabilitation for Veterans with upper extremity weakness due to stroke (Dr. Hochberg). Support to obtain this device would enable the collection of novel data, integrate and further collaboration around existing neurotechnologies at CfNN, and directly facilitate the development of novel technologies for Neurorestoration within the VHA System.

重度抑郁症、创伤后应激障碍（PTSD）和中风影响着数百万人