ShEEP Request to Acquire Brainsonix Advanced Focused Ultrasound System

严重的抑郁症、创伤后应激障碍(PTSD)和中风影响着数百万人 每年都有退伍军人。这些情况中的每一种都与严重的损害有关。 在心理社会功能方面。此外，现有的治疗方法疗效不大， 退伍军人的结果比一般人更差，这突显了 需要开发创新的新疗法。退伍军人事务部神经修复研究与开发中心 和神经科技(CfNN)是普罗维登斯VAMC、 布朗大学、巴特勒医院、长寿医院和马萨诸塞州综合医院 将研究人员和临床医生统一起来，目标是推进和翻译 恢复失去的功能的神经技术。通过此共享设备评估 计划申请，我们打算购买Brainsonix聚焦超声系统。 该设备将为退伍军人管理局的研究人员提供开发下一代大脑的机会 刺激研究；目前的技术完全依赖于电磁刺激， 从而限制了他们直接刺激与抑郁有关的大脑区域的能力， 创伤后应激障碍和中风。因此，该装置将用于CfNN研究的新推力 开发、测试和转化新的神经技术，以促进康复 对退伍军人来说。 该设备的主要用途包括：(1)测试和部署聚焦超声 为了改善严重的抑郁症(菲利普博士)，(2)发展聚焦超声作为一种新的 直接刺激涉及创伤后应激障碍的脑深部区域的治疗(谢伊博士)，以及(3) 聚焦超声增强神经康复治疗退伍军人高位畸形 中风导致的四肢无力(霍奇伯格医生)获取此设备的支持将 支持收集新数据，围绕现有数据进行集成和进一步协作 CfNN的神经技术，并直接促进新技术的开发 用于VHA系统内的神经修复。

Major depression, posttraumatic stress disorder (PTSD) and stroke affect millions of Veterans every year. Each of these conditions is associated with significant impairments in psychosocial function. Furthermore, existing treatments have modest efficacy, with even poorer outcomes in Veterans compared to the general population, underscoring the need to develop innovative new treatments. The VA RR&D Center for Neurorestoration and Neurotechnology (CfNN) is a unique collaboration between Providence VAMC, Brown University, Butler Hospital, Lifespan, and Massachusetts General Hospital that unifies researchers and clinicians with the goal of advancing and translating neurotechnology to restore lost function. Through this Shared Equipment Evaluation Program application, we intend to purchase a Brainsonix focused ultrasound system. This device will provide VA researchers to develop the next generation of brain stimulation research; current technologies rely solely upon electromagnetic stimulation, thus limiting their ability to directly stimulate brain regions involved in depression, PTSD and stroke. Thus, this device would be used in a new thrust of CfNN research to develop, test, and translate novel neurotechnologies in order to facilitate rehabilitation for Veterans. Major uses of the device would include (1) testing and deployment of focused ultrasound to improve major depression (Dr. Philip), (2) developing focused ultrasound as a novel treatment to directly stimulate deep brain regions involved in PTSD (Dr. Shea), and (3) using focused ultrasound-enhanced neurorehabilitation for Veterans with upper extremity weakness due to stroke (Dr. Hochberg). Support to obtain this device would enable the collection of novel data, integrate and further collaboration around existing neurotechnologies at CfNN, and directly facilitate the development of novel technologies for Neurorestoration within the VHA System.