Epigenetic Mediation of Adverse Social Context on Stress Response, Socioemotional Development, and Health in a Population-based Study of Minority and Low SES Children and Adolescents
在少数民族和低社会经济地位儿童和青少年的人口研究中,不良社会背景对压力反应、社会情感发展和健康的表观遗传调节
基本信息
- 批准号:10400673
- 负责人:
- 金额:$ 73.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2017
- 资助国家:美国
- 起止时间:2017-08-16 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:15 year old9 year oldAddressAdolescenceAdolescentAdultAffectAfrican ancestryAgeBase SequenceBehaviorBehavioralBiologicalBiological AssayBiological ProcessBirthBlack PopulationsBlack raceCharacteristicsChildChild DevelopmentChild RearingChild WelfareChildhoodCitiesCohort StudiesComplexDNADNA MethylationDataDevelopmentEpigenetic ProcessEthnic OriginEthnic groupEuropeanExposure toFamilyGenomeHealthHigh PrevalenceHispanicHispanic PopulationsHumanHydrocortisoneImprisonmentInequalityInternetInterviewLengthLinkLow incomeMeasurementMeasuresMediatingMediationMethylationMinorityModificationNeighborhoodsNot Hispanic or LatinoOutcomePersonal SatisfactionPopulationPopulation StudyPositioning AttributePovertyProblem behaviorRaceResearchResearch PersonnelRiskRisk-TakingSamplingSampling StudiesSocial ChangeSocial ConditionsSocial EnvironmentSocioeconomic StatusSourceStressTestingTimeVulnerable Populationsbehavior measurementbehavioral healthbehavioral responsebiological adaptation to stresscohortdehydroepiandrosteroneepigenomegenome-widehealth disparityhealth disparity populationsin uterolow socioeconomic statusmethylation patternmiddle childhoodminority childrenpopulation basedresilienceresponsesocialsocial adversitysupportive environmenttelomeretool
项目摘要
Project Abstract
Pronounced disparities exist by race, ethnicity, and SES in children and adolescents across a range of health
conditions, and many adult health disparities can be traced to childhood social contextual inequalities.
Epigenetics—modifications to the genome that are not changes in nucleotide sequence—holds great promise
as potential indicators of contextual effects and health condition, potentially uncovering health disparities long
before they are normally observable. Building on an existing representative study of children, this proposal will
directly respond to PAR-16-355 by: 1) assembling epigenome-wide data on 2,000 children at two points in
time, 2) describing methylation patterns in 3 race/ethnic groups and across SES levels, and 3) explicating
epigenetic associations with social adversity, biological processes, and socioemotional development. The
overarching hypothesis is that DNA methylation partially mediates the effect of adverse social context (i.e.
poverty, harsh parenting, neighborhood disorganization, family instability, and parental incarceration) on
biological processes related to stress response (telomere length and attrition, cortisol response, DHEA levels)
and stress responsive behaviors (behavioral problems, risk taking, and resilience). We further hypothesize
both differential exposure and differential response to adversity by race/ethnicity and SES explains some of the
disparity in stress response and socioemotional development—thereby requiring formal comparisons of
race/ethnicity and SES in the same study. To conduct this research we utilize the Fragile Families and Child
Wellbeing Study (FFCWS): a 20-city nationally and city representative sample of 4898 children born in 1998-
2000. FFCW provides a uniquely high prevalence of non-Hispanic Black (47%), Hispanic (27%), and
impoverished families, making the data particularly useful for studying race/ethnic and SES differences.
Families were interviewed at birth and at ages 1, 3, 5, 9, and 15—with biological data collected at ages 9 and
15. The expected results will be to provide estimates of: 1) population-based epigenome-wide DNA
methylation measures for 3 race/ethnic groups (Hispanic n=600, African ancestry n=980, European ancestry
n=420) in childhood and adolescence, 2) associations of social adversity across development (from in utero to
age 15) with DNA methylation, 3) associations between DNA methylation and biological measures of stress
response (i.e. telomere length and attrition, cortisol response, and DHEA levels), 4) associations
between development of stress response behaviors and methylation profiles, and 5) comparisons of all these
relationships in 3 race/ethnic groups and across a wide range of SES.
项目摘要
儿童和青少年在一系列健康问题上存在明显的种族、民族和社会经济地位差异,
许多成年人的健康差距可以追溯到儿童时期的社会背景不平等。
表观遗传学--对基因组进行的不改变核苷酸序列的修饰--有很大的希望
作为背景效应和健康状况的潜在指标,
才能被正常观察到在现有的一项关于儿童的代表性研究的基础上,这项建议将
通过以下方式直接响应PAR-16-355:1)收集2,000名儿童在两个时间点的表观基因组数据,
时间,2)描述3个种族/种族组和SES水平的甲基化模式,以及3)解释
表观遗传与社会逆境,生物过程和社会情感发展的联系。的
总体假设是DNA甲基化部分介导了不利的社会环境的影响(即,
贫困,严厉的养育,邻里混乱,家庭不稳定,和父母监禁)
与压力反应相关的生物学过程(端粒长度和磨损,皮质醇反应,DHEA水平)
和压力反应行为(行为问题,冒险和弹性)。我们进一步假设
种族/民族和SES对逆境的不同暴露和不同反应解释了一些
压力反应和社会情绪发展的差异,因此需要正式比较
种族/民族和SES在同一研究中。为了进行这项研究,我们利用脆弱家庭和儿童
幸福研究(FFCWS):一项全国20个城市和城市代表性样本,包括1998年出生的4898名儿童,
2000. FFCW提供了非西班牙裔黑人(47%),西班牙裔(27%)和
贫困家庭,使数据特别有用的研究种族/民族和社会经济地位的差异。
家庭在出生时和1岁,3岁,5岁,9岁和15岁时接受了采访,并在9岁和15岁时收集了生物数据。
15.预期的结果将提供估计:1)基于群体的表观基因组范围的DNA
3个人种/种族组的甲基化测量(西班牙裔n=600,非洲血统n=980,欧洲血统
n=420)在儿童和青少年,2)协会的社会逆境跨越发展(从子宫内到
15岁)与DNA甲基化,3)DNA甲基化和压力的生物措施之间的关联
反应(即端粒长度和磨损,皮质醇反应和DHEA水平),4)协会
应激反应行为的发展与甲基化谱之间的关系,以及5)所有这些的比较
3个种族/民族群体和广泛的社会经济地位之间的关系。
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving.
- DOI:10.3390/brainsci11111376
- 发表时间:2021-10-21
- 期刊:
- 影响因子:3.3
- 作者:Herrero-Roldán S;Rodrigo MJ;Hernández-Cabrera JA;Mitchell C;López M;Alcoba-Florez J;Fisher J;Espinosa F;León I
- 通讯作者:León I
Childhood violence exposure and social deprivation are linked to adolescent threat and reward neural function.
童年暴力暴露和社会剥夺与青少年威胁和奖励神经功能有关。
- DOI:10.1093/scan/nsaa144
- 发表时间:2020-12-17
- 期刊:
- 影响因子:4.2
- 作者:Hein TC;Goetschius LG;McLoyd VC;Brooks-Gunn J;McLanahan SS;Mitchell C;Lopez-Duran NL;Hyde LW;Monk CS
- 通讯作者:Monk CS
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COLTER M.S. MITCHELL其他文献
COLTER M.S. MITCHELL的其他文献
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{{ truncateString('COLTER M.S. MITCHELL', 18)}}的其他基金
The longitudinal impact of the COVID-19 pandemic and related multi-level mitigation and contextual factors on health and socioeconomic outcomes of individuals and families from a vulnerable population
COVID-19 大流行以及相关的多层次缓解措施和背景因素对弱势群体个人和家庭的健康和社会经济结果的纵向影响
- 批准号:
10705279 - 财政年份:2022
- 资助金额:
$ 73.42万 - 项目类别:
Epigenetic Mediation of Adverse Social Context on Stress Response, Socioemotional Development, and Health in a Population-based Study of Minority and Low SES Children and Adolescents
在少数民族和低社会经济地位儿童和青少年的人口研究中,不良社会背景对压力反应、社会情感发展和健康的表观遗传调节
- 批准号:
10162326 - 财政年份:2017
- 资助金额:
$ 73.42万 - 项目类别:
Epigenetic Mediation of Adverse Social Context on Stress Response, Socioemotional Development, and Health in a Population-based Study of Minority and Low SES Children and Adolescents
在少数民族和低社会经济地位儿童和青少年的人口研究中,不良社会背景对压力反应、社会情感发展和健康的表观遗传调节
- 批准号:
9386217 - 财政年份:2017
- 资助金额:
$ 73.42万 - 项目类别:
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