Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving.
Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving.
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DOI：
10.3390/brainsci11111376
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发表时间：
2021-10-21
期刊：
影响因子：
3.3
通讯作者：
León I
中科院分区：
文献类型：
--
作者：
Herrero-Roldán S;Rodrigo MJ;Hernández-Cabrera JA;Mitchell C;López M;Alcoba-Florez J;Fisher J;Espinosa F;León I
DNA甲基化时钟被用作表观遗传年龄的分子估计，但在母亲中几乎没有证据，在疏忽的母亲中也没有证据。我们使用PhenoAge时钟研究了表观遗传年龄加速(EAA)和移情作用的差异。我们收集了极度无视孩子需求的母亲的唾液样本(疏忽组50人)和非疏忽照顾母亲的唾液样本(对照组87人)。母亲们完成了一份同理心量表，以及关于她们童年虐待、不良生活事件和精神障碍的问卷。潜在影响EAA的社会人口学变量也被测量。ANCOVA解决方案显示，在对产妇年龄、怀孕次数、经济援助、不良事件、儿童期虐待和精神障碍进行调整后，NG组的EAA显著高于CG组。群体互动效应显示，更多的同理心和更高的教育水平是积极因素的EAA减少，而生活在双亲家庭的母亲的EAA增加是一个危险因素，所有这些都在NG中。我们的发现开启了寻找与照顾者行为相关的EAA的保护因素，以减少健康脆弱性和糟糕的社会功能，特别是对于面临照顾不良风险的母亲。
DNA methylation clocks are used as molecular estimators of epigenetic age, but with little evidence in mothers and none in neglectful mothering. We investigated differences in epigenetic age acceleration (EAA) and the role of empathy using the PhenoAge clock. We collected saliva samples from mothers with extreme disregard for their child’s needs (50 in the neglect group, NG) and mothers with non-neglectful caregiving (87 in the control group, CG). Mothers completed an empathy scale, along with questionnaires of their own childhood maltreatment, adverse life events and psychiatric disorders. Sociodemographic variables potentially affecting EAA were also measured. The ANCOVA solution showed a significant increase in EAA in the NG compared to the CG, after adjustment for maternal age, number of pregnancies, financial assistance, adverse events, childhood maltreatment and psychiatric disorder. The group interaction effects showed a reduction in EAA for greater empathic concern and for a higher education level both as positive factors, and an increment in EAA for mothers living in a two-parent family as a risk factor, all in the NG. Our findings open the search for protective factors of EAA associated with caregiver behavior to reduce health vulnerabilities and poor social functioning, especially for mothers at risk of maladaptive caregiving.
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DOI：
10.1146/annurev-clinpsy-032816-045005
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 13
影响因子：
--
作者：
Jaffee, Sara R.
通讯作者：
Jaffee, Sara R.
影响因子：
4.7
作者：
Hannighofer J;Foran H;Hahlweg K;Zimmermann T
通讯作者：
Zimmermann T
影响因子：
2.1
作者：
Ewing, E. Stephanie Krauthamer;Herres, Joanna;Trentacosta, Christopher J.
通讯作者：
Trentacosta, Christopher J.
影响因子：
4.2
作者：
Gruehn, Daniel;Rebucal, Kristine;Diehl, Manfred;Lumley, Mark;Labouvie-Vief, Gisela
通讯作者：
Labouvie-Vief, Gisela
影响因子：
4.4
作者：
Dube, SR;Anda, RF;Croft, JB
通讯作者：
Croft, JB