Childhood violence exposure and social deprivation are linked to adolescent threat and reward neural function.
Childhood violence exposure and social deprivation are linked to adolescent threat and reward neural function.
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童年暴力暴露和社会剥夺与青少年威胁和奖励神经功能有关。
DOI：
10.1093/scan/nsaa144
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发表时间：
2020-12-17
影响因子：
4.2
通讯作者：
Monk CS
中科院分区：
文献类型：
--
作者：
Hein TC;Goetschius LG;McLoyd VC;Brooks-Gunn J;McLanahan SS;Mitchell C;Lopez-Duran NL;Hyde LW;Monk CS
不幸的是，童年时期的逆境非常普遍，并与后来的精神病理密切相关。最近的理论认为，早期逆境的两个维度--威胁和剥夺--对大脑发育有不同的影响。目前的研究使用预先登记的开放科学方法，在一项前瞻性的、抽样充分的纵向队列中，评估了暴力暴露(威胁)和社会剥夺(剥夺)是否分别与青少年杏仁核和腹侧纹状体的激活有关。来自脆弱家庭和儿童福祉研究的167名青少年完成了功能磁共振成像(FMRI)扫描。3岁、5岁和9岁的前瞻性纵向数据被用来创建儿童暴力暴露和社会剥夺的指数。我们评估了这些维度是否与青少年对威胁和奖励面孔的反应的大脑功能有关。童年暴力暴露与青春期杏仁核习惯化(即更持久的激活)和对愤怒面孔的激活有关，而童年社交剥夺与青春期对快乐面孔的腹侧纹状体激活减少相关。当对逆境的另一个维度(例如，在检查与暴力暴露的关联时调整社会剥夺)、逆境的两个维度、性别、内化精神病理学和当前生活压力的相互作用时，这些关联仍然存在。与最近的理论一致，不同形式的早期逆境与大脑激活的区域差异有关。
Childhood adversity is, unfortunately, highly prevalent and strongly associated with later psychopathology. Recent theories posit that two dimensions of early adversity, threat and deprivation, have distinct effects on brain development. The current study evaluated whether violence exposure (threat) and social deprivation (deprivation) were associated with adolescent amygdala and ventral striatum activation, respectively, in a prospective, well-sampled, longitudinal cohort using a pre-registered, open science approach. One hundred and sixty-seven adolescents from the Fragile Families and Child Wellbeing Study completed functional magnetic resonance imaging (fMRI) scanning. Prospective longitudinal data from ages 3, 5 and 9 years were used to create indices of childhood violence exposure and social deprivation. We evaluated whether these dimensions were associated with adolescent brain function in response to threatening and rewarding faces. Childhood violence exposure was associated with decreased amygdala habituation (i.e. more sustained activation) and activation to angry faces in adolescence, whereas childhood social deprivation was associated with decreased ventral striatum activation to happy faces in adolescence. These associations held when adjusting for the other dimension of adversity (e.g., adjusting for social deprivation when examining associations with violence exposure), the interaction of the two dimensions of adversity, gender, internalizing psychopathology, and current life stress. Consistent with recent theories, different forms of early adversity were associated with region-specific differences in brain activation.
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影响因子：
4.2
作者：
Holz NE;Boecker-Schlier R;Buchmann AF;Blomeyer D;Jennen-Steinmetz C;Baumeister S;Plichta MM;Cattrell A;Schumann G;Esser G;Schmidt M;Buitelaar J;Meyer-Lindenberg A;Banaschewski T;Brandeis D;Laucht M
通讯作者：
Laucht M
影响因子：
5.7
作者：
Maldjian, JA;Laurienti, PJ;Burdette, JH
通讯作者：
Burdette, JH
影响因子：
--
作者：
Monk, Christopher S.;Telzer, Eva H.;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
5.7
作者：
Hein TC;Mattson WI;Dotterer HL;Mitchell C;Lopez-Duran N;Thomason ME;Peltier SJ;Welsh RC;Hyde LW;Monk CS
通讯作者：
Monk CS
影响因子：
10.6
作者：
Hanson JL;Hariri AR;Williamson DE
通讯作者：
Williamson DE