Diversity Supplement: SCH: Context-aware Freezing of Gait mitigation in real-world setting

多样性补充：SCH：现实环境中的情境感知冻结步态缓解

• 批准号: 10405314
• 负责人: Leslie J Cloud
• 金额: $ 6.82万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10405314
• 关键词: Address; Anxiety; Automobile Driving; Awareness; Behavior; Custom; Diagnosis; Elevator; Environmental Risk Factor; Freezing; Future; Gait; Health; Individual; Intention; Literature; Measures; Medical; Neuropsychology; Operative Surgical Procedures; Outcome; Parkinson Disease; Psychological Factors; Research; Role; Sleep; Sleep disturbances; Therapeutic; Time; Visual; Walking; anxious; experience; foot; indexing; psychologic; public health priorities; response; sleep health; symptomatology

Project Summary This proposal is submitted in response to PA-21-071: Research Supplements to Promote Diversity in Health- Related Research. This supplement seeks to examine neuropsychological contributors to freezing of gait (FoG), which is suffered by over 50% of people living with Parkinson’s Disease (PD) in order to reduce FoG burden. FoG, a common, devastating manifestation of PD for which there is no cure or adequate medical or surgical treatment, has been defined as a “brief, episodic absence or marked reduction of forward progression of the feet, despite the intention to walk.” It is widely known that FoG episodes are frequently triggered by various environmental and psychological factors. The most commonly recognized triggers include start hesitation (freezing upon gait initiation), walking through tight quarters, turn hesitation (freezing when changing directions), approaching a visual target, dual tasking, and stressful, time-sensitive situations such as entering an elevator before the doors close. Each individual with PD is unique with regard to how sensitive they are to these various triggers, underscoring the need for customized therapeutic approaches. As such, increased understanding of modifiable factors underlying FoG for increased understanding of individual nuances in experiences of FoG is warranted. Although anxiety has been established as an important psychological mechanism driving FoG behavior, there remains little to no research on neuropsychological factors that may precede FoG-inducing anxious symptomatology. Indeed, although it is known that anxiety is a precursor to FoG behaviors in individuals diagnosed with Parkinson’s Disease, less is known about the mechanisms contributing to this anxiety and underlying the association between anxiety and FoG outcomes broadly. An emerging body of research suggests that objectively and subjectively measured sleep is associated with both 1) anxiety and 2) FoG outcomes in individuals diagnosed with PD. In order to address key research gaps, this supplement will collect subjective and objective indices of anxiety, sleep, and other neuropsychological factors that influence FoG outcomes in individuals living with PD to promote increased understanding of and inform treatment targeted toward reduced burden associated with this phenomenon.

项目摘要 本提案是根据PA-21-071：促进卫生多样性的研究补充材料提交的。 相关研究。本附录旨在研究导致步态冻结(雾)的神经心理学因素， 超过50%的帕金森氏病(PD)患者都患有这种疾病，以减轻雾气负担。 雾是帕金森病的一种常见的破坏性表现，目前尚无治愈或适当的药物或手术治疗 治疗被定义为“短暂的、间歇性的足部前移消失或明显减少， 尽管有步行的意图。众所周知，雾事件经常是由各种不同的 环境和心理因素。最常见的触发因素包括开始犹豫 (步态开始时冻结)，在狭窄的区域行走，转弯犹豫(改变方向时冻结)， 接近视觉目标，双重任务，压力大，时间敏感的情况，如进入电梯 在门关上之前。每一个帕金森病患者都是独一无二的，他们对这些 触发因素，强调了定制治疗方法的必要性。因此，增加了对 雾背后的可修改因素是为了增加对雾经历中个体细微差别的理解 这是正当的。尽管焦虑已被确定为驱使雾气的重要心理机制 行为方面，对可能在致雾之前的神经心理因素的研究仍然很少或根本没有 焦虑的症状学。事实上，尽管我们知道焦虑是个体迷雾行为的先兆 被诊断为帕金森氏症，人们对导致这种焦虑的机制知之甚少 焦虑和雾结果之间的广泛联系。一项新兴的研究表明 客观和主观测量的睡眠与1)焦虑和2)雾结果有关 被诊断为帕金森病的个人。为了解决关键的研究差距，本附录将收集主观和 影响雾化结局的焦虑、睡眠和其他神经心理因素的客观指标 促进对帕金森病患者的了解，并告知针对减少的治疗目标的治疗 与这一现象相关的负担。