the self-tuning brain: cellular and circuit mechanisms of behavioral resilience
自调节大脑:行为弹性的细胞和回路机制
基本信息
- 批准号:10405344
- 负责人:
- 金额:$ 11.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2022-11-30
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAdultAffectAgingAnimalsBehaviorBehavioralBehavioral MechanismsBirdsBrainCell NucleusClinicalComplexComputer ModelsDataDetectionDiseaseElectrophysiology (science)EnsureExposure toFeedbackFunctional ImagingFutureGene DeliveryGeneticGoalsImageInjuryInterneuronsIon ChannelLearningMaintenanceMeasurableMeasuresMediatingMethodsModelingMotorMotor outputNervous System TraumaNeuronsNeurosciencesNoiseOutputPathologicPatternProductionPropertyRecoveryRecurrenceResearchSleepSongbirdsStereotypingSurfaceSynapsesTheoretical modelTimeauditory feedbackfunctional lossgenetic manipulationin vivoin vivo imaginginsightmotor behaviormotor learningmotor recoverynervous system disorderneuronal patterningoptogeneticspreventprogramsresilienceresponserestorationscaffoldtoolzebra finch
项目摘要
ABSTRACT
A major goal in clinical neuroscience is to develop efficient treatments to prevent or minimize the loss of
brain function caused by pathological decreases or increases of neuronal activity, which are hallmarks of a
wide variety of neurological disorders. Interestingly, in some instances, the brain has evolved mechanisms
to partially correct abnormal neuronal function. Understanding the adaptive mechanisms that restore brain
function would not only provide insight into the functioning of the normal brain but also guide future
approaches to ameliorate loss of brain function caused by disease or injury. We propose to start a research
program to investigate the cellular and circuit mechanisms by which the brain maintains constant behavioral
output, even when neuronal activity is naturally variable or it is perturbed. Our preliminary evidence with
songbirds indicate that the brain circuits involved in song production demonstrate a high level of behavioral
resilience both at short and long timescales. At the short timescale the patterns of firing of premotor
neurons directly involved in song production vary from day to day, although there is no measurable
variability in the song. At the long timescale, we genetically perturbed the activity of these premotor neurons
and this caused a dramatic disruption of song. However, manipulated birds fully recovered from the
perturbation, and were able to produce their original song after around 10 days. We will build on these
results to explore the neuronal mechanisms that ensure behavioral resilience in a brain circuit involved in a
complex behavior using gene delivery, optogenetics, in vivo functional imaging, behavioral analysis, and
computational modelling.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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Adrienne L Fairhall其他文献
Adrienne L Fairhall的其他文献
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{{ truncateString('Adrienne L Fairhall', 18)}}的其他基金
the self-tuning brain: cellular and circuit mechanisms of behavioral resilience
自调节大脑:行为弹性的细胞和回路机制
- 批准号:
10318583 - 财政年份:2017
- 资助金额:
$ 11.89万 - 项目类别:
the self-tuning brain: cellular and circuit mechanisms of behavioral resilience
自调节大脑:行为弹性的细胞和回路机制
- 批准号:
10058287 - 财政年份:2017
- 资助金额:
$ 11.89万 - 项目类别:
the self-tuning brain: cellular and circuit mechanisms of behavioral resilience
自调节大脑:行为弹性的细胞和回路机制
- 批准号:
9451082 - 财政年份:2017
- 资助金额:
$ 11.89万 - 项目类别:
the self-tuning brain: cellular and circuit mechanisms of behavioral resilience
自调节大脑:行为弹性的细胞和回路机制
- 批准号:
10673470 - 财政年份:2017
- 资助金额:
$ 11.89万 - 项目类别:
Computing and the brain: training the next generation of neuroscientists
计算和大脑:培养下一代神经科学家
- 批准号:
8312488 - 财政年份:2011
- 资助金额:
$ 11.89万 - 项目类别:
Computing and the Brain: Training the next generation of neuroscientists
计算和大脑:培训下一代神经科学家
- 批准号:
8723794 - 财政年份:2011
- 资助金额:
$ 11.89万 - 项目类别:
Undergraduate and graduate training in neural computation and engineering
神经计算和工程本科生和研究生培训
- 批准号:
9767102 - 财政年份:2011
- 资助金额:
$ 11.89万 - 项目类别:
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