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MARTIN, WILLIAM H:1197753 [19-007542]

马丁·威廉 H:1197753 [19-007542]

基本信息

批准号：
10403413
负责人：
WILLIAM MARTIN
金额：
$ 4.4万
依托单位：
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-20 至 2022-09-19
项目状态：
已结题

项目摘要

The Contractor shall provide consulting support services to the NIH Blueprint Neurotherapeutics Network as follows: Assay Development Assay Development consultants will be expected to provide senior-level Process Chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through conference calls and by email. The role of the Process Chemistry consultant may include but is not limited to the following responsibilities and tasks: • Consultants may be required to evaluate bioactivity assays and recommend strategies and experiments to optimize and/or validate the assays for use in a medicinal chemistry campaign. • Assay development consultants may be asked to assist in the establishment of milestones related to assay optimization or validation. • Consultant may be required provide guidance on the design and interpretation of commonly used in vivo assays, such as cognitive and behavioral tests. • Serve as the assay development expert in order to identify potential developmental challenges and suggest strategies to address these challenges on realistic timelines. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage programs to facilitate lead optimization, IND enabling, and clinical studies. • Serve as a resource to lead development team members for assay requirements, and logistics to conduct drug development activities for small molecule compounds from the preclinical stage through to the initial clinical stage. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage programs to facilitate lead optimization, IND enabling, and clinical studies. • Serve as a resource to lead development team members for assay requirements, and logistics to conduct drug development activities for small molecule compounds from the preclinical stage through to the initial clinical stage. • Collaborate on the design of investigative studies in support of development compounds.

承包商应为NIH蓝图神经治疗网络提供以下咨询支持服务：化验技术进展预计化验开发顾问将提供高级过程化学专业知识，并通过电话会议和电子邮件向NIH和LDT成员提供关于项目的反馈和指导。过程化学顾问的角色可能包括但不限于以下职责和任务： ·可能需要顾问对生物活性分析进行评估，并建议优化和/或验证用于药物化学活动的分析的策略和实验。 ·可请化验发展顾问协助建立与化验优化或验证有关的里程碑。 ·可能需要顾问就常用的活体测试的设计和解释提供指导，如认知和行为测试。 ·担任化验开发专家，以确定潜在的发展挑战，并提出战略，以便在现实的时间表内应对这些挑战。 ·与其他顾问、承包商和NIH工作人员合作，提供建议、战略规划和管理项目，以促进领导优化、IND支持和临床研究。 ·作为资源，领导开发团队成员满足化验要求，并为小分子化合物从临床前阶段到临床初始阶段进行药物开发活动提供后勤支持。 ·与其他顾问、承包商和NIH工作人员合作，提供建议、战略规划和管理项目，以促进领导优化、IND支持和临床研究。 ·作为资源，领导开发团队成员满足化验要求，并为小分子化合物从临床前阶段到临床初始阶段进行药物开发活动提供后勤支持。 ·合作设计调查性研究，以支持开发化合物。