MARTIN, WILLIAM H:1197753 [19-007542]

承包商应向 NIH 蓝图神经治疗网络提供如下咨询支持服务： 检测开发 检测开发顾问将提供高级过程化学专业知识，并通过电话会议和电子邮件向 NIH 和 LDT 成员提供项目反馈和指导。过程化学顾问的角色可能包括但不限于以下职责和任务： • 顾问可能需要评估生物活性测定并推荐策略和实验来优化和/或验证药物化学活动中使用的测定。 • 可能会要求检测开发顾问协助建立与检测优化或验证相关的里程碑。 • 可能需要顾问提供有关常用体内检测的设计和解释的指导，例如认知和行为测试。 • 担任检测开发专家，以确定潜在的开发挑战，并提出在现实的时间内应对这些挑战的策略。 • 与其他顾问、承包商和 NIH 工作人员合作，提供建议、战略规划和管理项目，以促进先导化合物优化、IND 实施和临床研究。 • 作为资源，引导开发团队成员满足化验要求，并提供后勤支持，以开展小分子化合物从临床前阶段到初始临床阶段的药物开发活动。 • 与其他顾问、承包商和 NIH 工作人员合作，提供建议、战略规划和管理项目，以促进先导化合物优化、IND 实施和临床研究。 • 作为资源，引导开发团队成员满足化验要求，并提供后勤支持，以开展小分子化合物从临床前阶段到初始临床阶段的药物开发活动。 • 合作设计调查研究以支持开发化合物。

The Contractor shall provide consulting support services to the NIH Blueprint Neurotherapeutics Network as follows: Assay Development Assay Development consultants will be expected to provide senior-level Process Chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through conference calls and by email. The role of the Process Chemistry consultant may include but is not limited to the following responsibilities and tasks: • Consultants may be required to evaluate bioactivity assays and recommend strategies and experiments to optimize and/or validate the assays for use in a medicinal chemistry campaign. • Assay development consultants may be asked to assist in the establishment of milestones related to assay optimization or validation. • Consultant may be required provide guidance on the design and interpretation of commonly used in vivo assays, such as cognitive and behavioral tests. • Serve as the assay development expert in order to identify potential developmental challenges and suggest strategies to address these challenges on realistic timelines. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage programs to facilitate lead optimization, IND enabling, and clinical studies. • Serve as a resource to lead development team members for assay requirements, and logistics to conduct drug development activities for small molecule compounds from the preclinical stage through to the initial clinical stage. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage programs to facilitate lead optimization, IND enabling, and clinical studies. • Serve as a resource to lead development team members for assay requirements, and logistics to conduct drug development activities for small molecule compounds from the preclinical stage through to the initial clinical stage. • Collaborate on the design of investigative studies in support of development compounds.