MARTIN, WILLIAM H:1197753 [19-007542]

马丁·威廉 H:1197753 [19-007542]

• 批准号: 10664816
• 负责人: WILLIAM MARTIN
• 金额: $ 1万
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-20 至 2022-09-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10664816
• 关键词: Address; Biological Assay; Chemistry; Clinical; Clinical Research; Consult; Contractor; Development; Electronic Mail; Feedback; Lead; Logistics; Pharmaceutical Chemistry; Process; Resources; Role; Services; Strategic Planning; TimeLine; United States National Institutes of Health; Validation; assay development; behavior test; cognitive testing; design; drug development; experimental study; in vivo; lead optimization; member; pre-clinical; programs; small molecule; symposium

The Contractor shall provide consulting support services to the NIH Blueprint Neurotherapeutics Network as follows: Assay Development Assay Development consultants will be expected to provide senior-level Process Chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through conference calls and by email. The role of the Process Chemistry consultant may include but is not limited to the following responsibilities and tasks: • Consultants may be required to evaluate bioactivity assays and recommend strategies and experiments to optimize and/or validate the assays for use in a medicinal chemistry campaign. • Assay development consultants may be asked to assist in the establishment of milestones related to assay optimization or validation. • Consultant may be required provide guidance on the design and interpretation of commonly used in vivo assays, such as cognitive and behavioral tests. • Serve as the assay development expert in order to identify potential developmental challenges and suggest strategies to address these challenges on realistic timelines. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage programs to facilitate lead optimization, IND enabling, and clinical studies. • Serve as a resource to lead development team members for assay requirements, and logistics to conduct drug development activities for small molecule compounds from the preclinical stage through to the initial clinical stage. • In partnership with other consultants, contractors, and the NIH staff, advise, strategically plan, and manage programs to facilitate lead optimization, IND enabling, and clinical studies. • Serve as a resource to lead development team members for assay requirements, and logistics to conduct drug development activities for small molecule compounds from the preclinical stage through to the initial clinical stage. • Collaborate on the design of investigative studies in support of development compounds.

承包商应向NIH Blueprint Neurotherapeutics Network提供以下咨询支持服务： 检测开发 检测开发顾问将提供高级工艺化学专业知识，并通过电话会议和电子邮件向NIH和LDT成员提供项目反馈和指导。工艺化学顾问的职责可能包括但不限于以下职责和任务： · 可能需要顾问评估生物活性测定并推荐策略和实验，以优化和/或验证用于药物化学活动的测定。 · 可能要求检测开发顾问协助建立与检测优化或验证相关的里程碑。 · 可能需要顾问就常用的体内试验（如认知和行为测试）的设计和解释提供指导。 · 作为检测试剂盒开发专家，以识别潜在的开发挑战，并提出在现实时间表内解决这些挑战的策略。 · 与其他顾问，承包商和NIH工作人员合作，提供建议，战略规划和管理计划，以促进铅优化，IND启用和临床研究。 · 作为一种资源，领导开发团队成员的分析要求，并从临床前阶段到初始临床阶段进行小分子化合物的药物开发活动的物流。 · 与其他顾问，承包商和NIH工作人员合作，提供建议，战略规划和管理计划，以促进铅优化，IND启用和临床研究。 · 作为一种资源，领导开发团队成员的分析要求，并从临床前阶段到初始临床阶段进行小分子化合物的药物开发活动的物流。 · 合作设计调查研究，以支持开发化合物。