Mechanisms that underlie cross-modal sensory plasticity - Diversity Research Supplements to Promote Diversity in Health-Related Research

项目总结 发育过程中的感觉体验深刻地影响着成熟动物的感觉加工。自.以来 大多数动物的感觉体验是多通道的，一种感觉通道的活动通常会导致 另一种形态的长期变化。这种跨模式的可塑性不仅导致补偿 感觉功能在感觉剥夺的情况下，也允许正常个体做出正确的反应 在他们独特的环境或情况下对感觉刺激的影响，并导致个体在 对多感官线索的感知。尽管跨模式可塑性很重要，但潜在的电路和 分子机制还不是很清楚。家长资助R01NS104299的目标是确定 果蝇躯体感觉系统发育中跨模式可塑性的机制 并为指导其他物种未来的研究提供了电路和分子模型。中环 假设在发育过程中温和的机械感觉输入加强了5-羟色胺能抑制 从伤害性感受器到多感觉二级神经元的突触传递，即 是通过MSON中的特定基因实现的。为促进多样性而索要的研究副刊 在与健康相关的研究方面，将支持培训一名杰出的学士后毕业生。这项研究 拟议的研究将补充原先拟议的研究，以确保成功地实现其目标。 提议进行两项研究来补充最初的目标2：(1)确定是否需要FMRP 跨模型行为可塑性；以及(2)确定跨模型可塑性是否影响神经集合 活动。这些研究活动将扩大补充对象的研究经验。此外， 他们将为她提供学习科学写作、口头演示技能和网络的机会。 这些培训将为她从事与健康相关的研究事业奠定坚实的基础。

PROJECT SUMMARY Sensory experiences during development profoundly influence sensory processing in mature animals. Since most of an animal’s sensory experiences are multimodal, the activity of one sensory modality often causes long-term changes in another modality. Such cross-modal plasticity not only leads to compensation for sensory functions in the case of sensory deprivation, but also allows normal individuals to respond properly to sensory stimuli in their unique habitats or situations and contributes to individual’s differences in the perception of multisensory cues. Despite the importance of cross-modal plasticity, the underlying circuit and molecular mechanisms are poorly understood. The objective of the parent grant R01NS104299 is to identify the mechanisms that underlie cross-modal plasticity in the developing somatosensory system of Drosophila larvae, and provide circuit and molecular models for guiding future studies in other species. The central hypothesis is that gentle mechanosensory inputs during development strengthen serotonergic inhibition of the synaptic transmission from nociceptors to multisensory second-order neurons (MSONs), which is achieved through specific genes in the MSONs. The requested Research Supplement to Promote Diversity in Health-Related Research will support the training of an outstanding postbaccalaureate. The research proposed will supplement the originally proposed studies to ensure the successful attainment of its aims. Two studies are proposed to supplement the original Aim 2: (1) determine whether FMRP is required for cross-model behavioral plasticity; and (2) determine whether cross-modal plasticity affects neural ensemble activities. These research activities will expand the research experiences of the supplementee. Moreover, they will provide opportunities for her to learn scientific writing, oral presentation skills, and networking. These training will position her strongly for a health-related research career.