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Mechanisms that underlie cross-modal sensory plasticity

跨模式感觉可塑性的机制

基本信息

批准号：
10440450
负责人：
BING YE
金额：
$ 32.73万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10440450
关键词：
Animals Behavior Behavioral Childhood Clinical Complement Complex Cues Defect Development Disease Drosophila genus Financial compensation Future Genes Genetic Genetic Screening Glucose Habitats Imaging Techniques Individual Individual Differences Interneurons Knowledge Larva Mission Modality Modeling Molecular Molecular Genetics Neurodevelopmental Disorder Neurons Nociception Nociceptors Output Patch-Clamp Techniques Pathogenesis Pathway interactions Perception Play Preparation Process Public Health Research Role Sensory Sensory Deprivation Signal Transduction Somatosensory Cortex Stimulus Symptoms Synapses Synaptic Transmission Synaptic plasticity System Tactile Techniques Testing United States National Institutes of Health V1 neuron Vision Visually Impaired Persons area striata behavioral plasticity developmental plasticity experience gene function genetic analysis genetic approach genome editing improved innovation insight mature animal molecular modeling multidisciplinary multimodality multisensory nervous system disorder neural circuit neuroregulation neurotransmitter release new technology novel recruit sensory stimulus sensory system somatosensory spatiotemporal synaptic inhibition transmission process ubiquitin ligase

项目摘要

Sensory experiences during development profoundly influence sensory processing in mature animals. Since most of an animal’s sensory experiences are multimodal, the activity of one sensory modality often causes long-term changes in another modality. Such cross-modal plasticity not only leads to compensation for sensory functions in the case of sensory deprivation, but also allows normal individuals to respond properly to sensory stimuli in their unique habitats or situations and contributes to individual’s differences in the perception of multisensory cues. Despite the importance of cross-modal plasticity, the underlying circuit and molecular mechanisms are poorly understood. In the proposed research, a novel form of cross-modal plasticity has been discovered in Drosophila and developed into a system for studying the underlying mechanisms at the behavioral, circuit, synaptic, and molecular levels. This system allows for comparison of cross-modal and modality-specific plasticity in the same sensory system. A genetic screen has identified novel regulators of cross-modal plasticity. The objective of the proposed research is to identify the mechanisms that underlie cross-modal plasticity in the developing somatosensory system of Drosophila larvae, and provide circuit and molecular models for guiding future studies in other species. The central hypothesis is that gentle mechanosensory inputs during development strengthen serotonergic inhibition of the synaptic transmission from nociceptors to multisensory second-order neurons (MSONs), which is achieved through specific genes in the MSONs. This hypothesis will be tested by identifying the circuit (Aim 1) and molecular (Aim 2) mechanisms that underlie cross-modal plasticity. The proposed research is innovative because it proposes the novel concept of distinct mechanisms that underlie cross-modal and modality-specific plasticity and will use a novel system that is amenable to the use of genetic screens to study cross-modal plasticity. This research is significant because it is expected to: 1) elucidate how cross- modal and modality-specific plasticity co-exist in a developing sensory system and demonstrate the role of neuromodulatory interneurons in establishing cross-modal plasticity during development; 2) identify a novel molecular mechanism that underlies cross-modal plasticity, particularly one that distinguishes it from modality-specific plasticity within the same neural circuit; 3) yield a multidisciplinary, state-of-the-art experimental system for identifying the principles that govern the experience--dependent assembly of neural circuits for multisensory integration. Moreover, because a common problem of many neurodevelopmental disorders is dysregulated multisensory integration, the proposed study will offer insights into the pathogenesis of these disorders.

发育过程中的感觉体验深刻影响着成熟动物的感觉加工。自

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Identification of Neuronal Lineages in the Drosophila Peripheral Nervous System with a "Digital" Multi-spectral Lineage Tracing System.

用“数字”多光谱谱系追踪系统鉴定果蝇周围神经系统中的神经元谱系。

DOI：
10.1016/j.celrep.2019.10.124
发表时间：
2019
期刊：
Cell reports
影响因子：
8.8
作者：
Veling,MacyW;Li,Ye;Veling,MikeT;Litts,Christopher;Michki,Nigel;Liu,Hao;Ye,Bing;Cai,Dawen
通讯作者：
Cai,Dawen

isoTarget: A Genetic Method for Analyzing the Functional Diversity of Splicing Isoforms In Vivo.