Prenatal Cannabis Use: Prevalence, Characteristics, and Outcomes

产前大麻使用：流行率、特征和结果

• 批准号: 10401104
• 负责人: Charles James Barone
• 金额: $ 12.08万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10401104
• 关键词: Adult; Adverse drug effect; Affect; Agreement; Anemia; Anxiety; Archives; Biological; Birth; Cannabis; Characteristics; Child; Child Health; Childhood; Classification; Clinical; Conflict (Psychology); Data; Databases; Demographic Factors; Discipline of obstetrics; Dose; Drug usage; Exposure to; Fetal Growth; Fetal health; Fetus; Fright; Funding; Gestational Age; Gestational Diabetes; Goals; Health; Health Policy; Health Promotion; Infant Health; Knowledge; Laws; Legal; Light; Maternal Health; Maternal and Child Health; Measurement; Measures; Medical; Medical Records; Mental Depression; Methodology; Methods; Michigan; Monitor; Mothers; Outcome; Participant; Patient Self-Report; Personal Satisfaction; Placenta; Policies; Population; Populations at Risk; Pregnancy; Pregnant Women; Prenatal care; Prevalence; Process; Protocols documentation; Public Health; Questionnaires; Research; Risk; Risk Assessment; Sampling; Selection Bias; Social Desirability; Socioeconomic Status; Stress; Surveys; System; THC concentration; Testing; Tetrahydrocannabinol; Therapeutic; Therapeutic Uses; Tobacco; Tobacco use; Toxicology; Training; United States; United States National Institutes of Health; Urine; Weight Gain; Woman; base; career; clinical practice; cohort; design; fetal marijuana exposure; gestational weight gain; health of the mother; improved; infant outcome; innovation; intervention program; marijuana legalization; marijuana use; marijuana use in pregnancy; marijuana user; maternal outcome; neonatal health; neonatal outcome; pregnant; prenatal; prenatal exposure; prevent; preventive intervention; prospective; psychosocial; substance use; trend; virtual; warning label

Project summary/abstract Cannabis use during pregnancy is a growing public health concern in the United States as more states are legalizing medical and recreational use. Its prenatal use has significant implications for the health of the mother and her developing child. Tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, crosses the placenta, with greater transfer during the early stages of pregnancy. Thus, it is important to understand the prevalence and effects of prenatal cannabis using objective methods, since the prenatal period is a unique window of opportunity to prevent adverse neonatal outcomes. The present study will be based on the NIH-funded MARCH (Michigan Archive for Research in Child Health) open cohort that represents a stratified random sample of births in the lower peninsula of Michigan. This ongoing cohort, initiated in 2017, collects questionnaires, medical records and biological samples beginning with the first prenatal visit until later childhood, accruing a wealth of data on prenatal exposures and outcomes. Given this rich database, we propose to examine the following specific aims: Aim 1: Assess agreement between self-reported cannabis use and urine toxicology measures and determine correlates of non-disclosure; Aim 2: Assess the prevalence and associated characteristics (socioeconomic status, demographic factors, psychosocial wellbeing, and concurrent use of other substances) of cannabis use during pregnancy; Aim 3: Assess the effect of prenatal cannabis use on key neonatal outcomes; and Aim 4: Explore the effect of prenatal cannabis use on important obstetric/maternal outcomes.

项目概要/摘要 在美国，怀孕期间使用大麻是一个日益严重的公共卫生问题，因为越来越多的州将医疗保健合法化。 和娱乐用途。它的产前使用对母亲及其发育中的孩子的健康有重大影响。 大麻的主要精神活性成分四氢大麻酚（THC）穿过胎盘， 在怀孕的早期阶段因此，了解产前大麻的流行率和影响非常重要。 使用客观的方法，因为产前时期是一个独特的机会窗口，以防止不良新生儿 结果。目前的研究将基于NIH资助的MARCH（密歇根州儿童健康研究档案） 开放队列，代表密歇根州下半岛出生的分层随机样本。这个正在进行的队列， 从2017年开始，从第一次产前检查开始收集问卷，医疗记录和生物样本 直到童年后期，积累了大量关于产前暴露和结果的数据。鉴于这个丰富的数据库，我们建议 目的1：评估自我报告的大麻使用与尿液毒理学之间的一致性 衡量和确定不披露的相关因素;目标2：评估不披露的普遍性和相关特征 （社会经济地位、人口因素、心理健康和同时使用其他物质） 目标3：评估产前使用大麻对关键新生儿结局的影响;目标4：探索 产前使用大麻对重要的产科/孕产妇结果的影响。