产前大麻使用：流行率、特征和结果-猫眼课题宝

产前大麻使用：流行率、特征和结果

批准号：

10401104

负责人：

Charles James Barone

金额：

$12.08万

依托单位：

MICHIGAN STATE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2016

资助国家：

美国

项目状态：

已结题

起止时间：

2016-09-21 至 2023-08-31

来源：

https://reporter.nih.gov/project-details/10401104

关键词：

Adult Adverse drug effect Affect Agreement Anemia Anxiety Archives Biological Birth Cannabis Characteristics Child Child Health Childhood Classification Clinical Conflict (Psychology)Data Databases Demographic Factors Discipline of obstetrics Dose Drug usage Exposure to Fetal Growth Fetal health Fetus Fright Funding Gestational Age Gestational Diabetes Goals Health Health Policy Health Promotion Infant Health Knowledge Laws Legal Light Maternal Health Maternal and Child Health Measurement Measures Medical Medical Records Mental Depression Methodology Methods Michigan Monitor Mothers Outcome Participant Patient Self-Report Personal Satisfaction Placenta Policies Population Populations at Risk Pregnancy Pregnant Women Prenatal care Prevalence Process Protocols documentation Public Health Questionnaires Research Risk Risk Assessment Sampling Selection Bias Social Desirability Socioeconomic Status Stress Surveys System THC concentration Testing Tetrahydrocannabinol Therapeutic Therapeutic Uses Tobacco Tobacco use Toxicology Training United States United States National Institutes of Health Urine Weight Gain Woman base career clinical practice cohort design fetal marijuana exposure gestational weight gain health of the mother improved infant outcome innovation intervention program marijuana legalization marijuana use marijuana use in pregnancy marijuana user maternal outcome neonatal health neonatal outcome pregnant prenatal prenatal exposure prevent preventive intervention prospective psychosocial substance use trend virtual warning label

中文摘要

翻译

项目摘要/摘要随着越来越多的州将大麻合法化，怀孕期间使用大麻在美国成为一个日益严重的公共卫生问题和娱乐用途。它的产前使用对母亲及其发育中的孩子的健康有重大影响。四氢大麻酚(THC)是大麻的主要精神活性成分，通过胎盘有更大的转移在怀孕的早期阶段。因此，重要的是要了解产前大麻的流行率和影响。使用客观方法，因为产前是预防不良新生儿的唯一机会之窗结果。这项研究将基于美国国立卫生研究院资助的MARCH(密歇根儿童健康研究档案) 代表密歇根州下半岛出生人口的分层随机抽样的开放队列。这个正在进行的队列，于2017年启动，从第一次产前检查开始收集问卷、医疗记录和生物样本直到童年后期，积累了大量关于产前暴露和结局的数据。考虑到这个丰富的数据库，我们建议审查以下具体目标：目标1：评估自我报告的大麻使用与尿毒学之间的一致性衡量和确定不披露的相关因素；目标2：评估流行率和相关特征 (社会经济地位、人口因素、心理健康和同时使用其他物质)大麻在怀孕期间使用大麻；目标3：评估产前使用大麻对关键新生儿结局的影响；目标4：探索产前使用大麻对重要的产科/产妇结局的影响。

英文摘要

Project summary/abstract Cannabis use during pregnancy is a growing public health concern in the United States as more states are legalizing medical and recreational use. Its prenatal use has significant implications for the health of the mother and her developing child. Tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis, crosses the placenta, with greater transfer during the early stages of pregnancy. Thus, it is important to understand the prevalence and effects of prenatal cannabis using objective methods, since the prenatal period is a unique window of opportunity to prevent adverse neonatal outcomes. The present study will be based on the NIH-funded MARCH (Michigan Archive for Research in Child Health) open cohort that represents a stratified random sample of births in the lower peninsula of Michigan. This ongoing cohort, initiated in 2017, collects questionnaires, medical records and biological samples beginning with the first prenatal visit until later childhood, accruing a wealth of data on prenatal exposures and outcomes. Given this rich database, we propose to examine the following specific aims: Aim 1: Assess agreement between self-reported cannabis use and urine toxicology measures and determine correlates of non-disclosure; Aim 2: Assess the prevalence and associated characteristics (socioeconomic status, demographic factors, psychosocial wellbeing, and concurrent use of other substances) of cannabis use during pregnancy; Aim 3: Assess the effect of prenatal cannabis use on key neonatal outcomes; and Aim 4: Explore the effect of prenatal cannabis use on important obstetric/maternal outcomes.

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