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Prenatal Exposures and Child Health Outcomes: A Statewide Study

产前暴露和儿童健康结果：一项全州研究

基本信息

批准号：
10240599
负责人：
Charles James Barone
金额：
$ 290.16万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10240599
关键词：
Age Antibiotics Asthma Behavior Biological Birth Blood Body Weight Changes Body mass index Characteristics Chemicals Child Child Development Child Health Clinic Clinics and Hospitals Cognitive Collection Consent Data Development Diet Enrollment Environment Environmental Exposure Environmental Pollution Epigenetic Process Exposure to Family Feeding Patterns Fetus Freezing Generations Genetic Screening Grant Health Heavy Metals Hospitals Impaired cognition Infant Infection Inflammation Inflammatory Inflammatory Response Institution Interview Iodine Iron Learning Link Longitudinal cohort study Maternal Exposure Maternal-Fetal Exchange Measurement Measures Mediating Metals Michigan Mothers Neonatal Newborn Infant Nutrition Assessment Nutritional Obesity Outcome Parental Consent Pathway interactions Patient Self-Report Perchlorates Phase Pilot Projects Placenta Plasma Pregnancy Probability Samples Procedures Research Personnel Resources Risk Sampling Savings Serum Specimen Spottings Testing Thiocyanates Thyroid Gland Thyroid Hormones Tooth structure Toxin Urine Virus Diseases Weight Woman autism spectrum disorder biobank biological specimen archives cohort contaminated water early pregnancy epigenomics follow-up in utero infant gut microbiome lead exposure maternal obesity member microbiome microbiota neurodevelopment obesity in children perinatal outcomes perinatal period persistent organic pollutants pregnant prenatal prenatal exposure prevent psychologic psychosocial recruit social uptake

项目摘要

Project Summary For many environmental exposures the most sensitive period of risk for later child health is pregnancy and the perinatal period, and these exposures are best ascertained from maternal self-report, biological specimens and objective environmental data collected during pregnancy and immediately after birth. This study will examine this sensitive period, measuring environmental contaminants, nutritional factors and inflammation in some 2,000 mother infant pairs in the context of their social and psychological environment. We have two cohorts totaling nearly 1,000 women enrolled, interviewed and sampled early in pregnancy (most before 14 weeks) with biological specimens archived, and are now expanding the larger of our two cohorts to a statewide probability sample of Michigan hospitals and clinics to enroll 1,000 more pregnancies. We are in contact with more than 84% of our extant cohort members. We will use newborn dried blood spots (NDBS) from the Michigan Neonatal Biobank to further quantify environmental exposures, examine epigenomic changes, and, by accessing both the child's and the mother's newborn spots, study environmental effects across generations. In Flint, MI we will examine the effects of recent water contamination on fetus and child. We will focus on three important exposures in pregnancy. First, we will determine the effects of persistent organic pollutants (POPs) and heavy metals on cognitive outcomes. We hypothesize that the effects of these toxins will be mediated by epigenetic changes measured on NDBS, and will be amplified by grant-maternal exposure (measured on mother's blood spot when she was a newborn). We hypothesize that recent in utero lead exposure in Flint, MI, as assessed in NDBS, and in the shed teeth of exposed children, will also be associated with impaired cognitive outcomes. Second, we will assess the effect of maternal nutritional and weight status in pregnancy on cognitive outcomes and childhood obesity, with a special focus on low pregnancy iodine and/or iron status, agents interfering with thyroid iodine uptake (perchlorate, thiocyanate), abnormal thyroid hormone function and pregnancy-related weight changes. Finally, we will assess the effects of pregnancy viral infection and maternal obesity on perinatal outcomes and behavior related to the autism spectrum. The effects of viral infections and maternal obesity are hypothesized to be mediated by increased placental and neonatal inflammation. The infant gut microbiome will also be assessed, as we anticipate that it may be a pathway linking both nutritional factors and pregnancy inflammation to adverse child health outcomes.

项目总结