Cancer Center Support Grant

项目摘要 这 21-026”。 表示“低”之义 耻辱 癌 癌 宫颈 癌 和 研究所 测量 宫颈 耶鲁 的 这 解释性 性 促进者 在 性 随机 探索 社区 成员 个人， 耻辱 减少 在 申请正在提交，以响应标识为“NOT-CA-”的特别利益通知（NOSI）。 宫颈癌是世界上最常见的女性癌症， 和中等收入国家，85%的宫颈癌病例发生在这些国家。癌症耻辱和性 可能是成功的癌症预防，筛查和治疗计划的障碍， 持续护理，特别是癌症筛查和治疗。宫颈癌与 而人类乳头状瘤病毒，一种常见的性传播感染（STI）， 癌因此，有必要了解癌症和性耻辱对宫颈癌的影响。 筛查和接受治疗，以制定干预措施，减少污名化并加强筛查 治疗耶鲁大学实施和预防科学方法中心，与 执行科学与卫生部和尼泊尔加德满都大学正在进行一项研究， 的可接受性、可行性、成本和可持续性，并探讨其因素和障碍， 在尼泊尔中部进行癌症筛查和治疗，由该补助金的母公司赠款提供支持， 癌症中心（YCC）P30 CA 016359，“耶鲁综合癌症中心支持补助金”， 本补充申请的主要研究者担任全球肿瘤学助理总监， 为配合这项研究的进行，我们建议推行一项 混合方法评估宫颈癌污名的影响，以及其他交叉 对宫颈癌筛查摄取和伴侣披露的耻辱，并探索驱动因素， 这样的耻辱。癌症耻辱量表和性传播感染耻辱和羞耻量表 尼泊尔进一步研究了癌症与癌症之间的潜在联系， 在424名女性中， 在尼泊尔中部Dhulikhel市选定30至60岁的妇女。目标2将 宫颈癌污名化的驱动因素、促进因素和表现， 在有目的地选择的妇女（n=8），家庭， （n=8）和社区领导人（n=8）在健康耻辱和歧视框架的指导下， 家庭、保健提供者和社区一级，旨在确定未来有希望的组成部分， 减少干预。这项研究将为今后的方案努力提供关键因素的见解， 在资源匮乏的环境中，提高妇女获得宫颈癌筛查和治疗的机会， 与此同时，进一步加强母基金的全球肿瘤学项目。 C C R . 目标1将验证 采用验证性因素分析;以及

PROJECT SUMMARY This 21-026”. low- stigma cancer cancer cervical cancer and Institute measure cervical Yale the this explanatory sexual facilitators in sexual randomly explore community members individual, stigma reduce at application is being submitted in response to the Notice of Special Interest (NOSI) identified as "NOT-CA- Cervical cancer is the most common cancer among women in the world, disproportionately affecting and middle-income ountries, where 85% of cervical cancer cases occur. Cancer stigma and sexual may be obstacles to successful cancer prevention, screening and treatment programs, undermining the care continuum, particularly with ervical cancer screening and treatment. The link between cervical and the human papilloma virus, a common sexually transmitted infection (STI), has further stigmatized cancer. I t is, therefore, necessary to understand the impact of cancer and sexual stigma on cervical screening and treatment uptake to develop interventions to educe stigma and strengthen screening treatment. The Yale Center for Methods in I mplementation and Prevention Science, in collaboration with f or Implementation Science and Health and Kathmandu University in Nepal, is conducting a study t o acceptability, feasibility, cost, and sustainability of, as well as to explore f acilitators and barriers to, cancer screening and treatment in central Nepal, supported by the parent grant to this supplement, Cancer Center's (YCC) P30 CA016359, “Yale Comprehensive Cancer Center Support Grant”, for which principal investigator of t his supplement application serves as Assistant Director, Global Oncology With research well underway to serve as a platform for the current study, we propose to implement an mixed-method approach to assess the i nfluence of cervical cancer stigma, and other intersecting stigmas on cervica l cancer screening uptake and partner disclosure, and explore the drivers and of such stigma. the cancer stigma scale and STI stigma and shame scale for use Nepal further, examine the prospective association of cancer and stigma with the uptake and disclosure to male partners of cervical cancer screening among 424 selected women of 30 to 60 years residing in the Dhulikhel municipality in central Nepal. Aim 2 will the drivers, facilitators and manifestations of cervical cancer stigma at individual, family, and level using qualitative in-depth interviews among purposively selected women (n=8), family (n=8) and community leaders (n=8) guided by the Health Stigma and Discrimination Framework at family, health provider and community level, aiming to identify promising components of a future reduction intervention. The study will provide insights into key factors for future programmatic efforts to stigma and improve access to cervical cancer screening and treatment in low resource settings, while, the same time, further strengthening the parent grant's Global Oncology Program. c c r . Aim 1 will validate using confirmatory factor analysis; and