P50-Admin Core-Harris/Garb

P50-管理核心-Harris/Garb

• 批准号: 10404443
• 负责人: John E Harris
• 金额: $ 21.24万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-12 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404443
• 关键词: Achievement; Advisory Committees; Affect; Atopic Dermatitis; Autoimmune Diseases; Autoimmunity; Budgets; Caregiver research; Cell Culture Techniques; Cells; Clinical Research; Collaborations; Communication; Communities; Complex; Data; Dermatologist; Disease; Disputes; Education; Ensure; Evaluation; Event; FDA approved; Funding; General Population; Generations; Genetic Risk; Goals; Grant; Human; Human Resources; Immunologist; Individual; Information Dissemination; Insulin-Dependent Diabetes Mellitus; Knowledge; Lead; Leadership; Left; Modeling; Multiple Sclerosis; Nature; Occupational activity of managing finances; Outcome; Participant; Pathogenesis; Patients; Physicians; Population; Progress Reports; Psoriasis; Publications; RNA; Research; Research Personnel; Resolution; Resources; Rheumatoid Arthritis; Sampling; Schedule; Scientific Advances and Accomplishments; Scientist; Signal Pathway; Signal Transduction; Skin; System; T-Cell Receptor; T-Lymphocyte; Time; Tissues; Translational Research; United States National Institutes of Health; Vitiligo; White Spots; Workload; chemokine; clinical care; cohesion; collaborative environment; experience; health disparity; improved; innovation; insight; interdisciplinary approach; meetings; multidisciplinary; multiple omics; neoantigens; outreach; outreach program; psychologic; research study; risk variant; skin disorder; skin lesion; success; tool; transcriptomics; treatment strategy

Over 70 million individuals worldwide suffer from vitiligo, a psychologically devastating autoimmune disease of the skin that causes disfiguring white spots and disproportionately affects those with darker skin. This, com- bined with a lack of FDA-approved treatments for vitiligo, creates a concerning health disparity for some of the most vulnerable of our population. Because of the accessibility of the skin, vitiligo provides a unique oppor- tunity for detailed, innovative translational research studies that provide insight into its pathogenesis and lead to improved treatment strategies. Further, vitiligo shares genetic risk alleles and other mechanisms with auto- immune diseases that are more complex and/or difficult to study using translational tools and thus provides an unparalleled model through which to understand mechanisms of human autoimmunity. We have generated preliminary data using a translational multi-omics approach that reveal thousands of new data points marking hundreds of new signaling pathways that coordinate autoimmunity in the skin during viti- ligo. What remains lacking, however, is an integrated, multidisciplinary approach to assemble this new data into a comprehensive understanding of disease pathogenesis within vitiligo skin lesions. Thus, there is a critical need to establish a coordinated, collaborative effort to reveal new, high-resolution insight into the pathogenesis of vitiligo and other autoimmune diseases that could support innovative, advanced treatment strategies. We will leverage our existing data, leading multidisciplinary investigative team, and cutting-edge research tools to accomplish this task within the Vitiligo Center of Research Translation (VCORT). Strong communication, coordination, fiscal management, education, and dissemination of information will be critical to the success of this multidisciplinary effort. The overall objective of the Administrative Core is to serve as an interface among VCORT participants to promote the generation and dissemination of knowledge among the collaborative inves- tigators, the broader scientific community, and the public. We will do this through the following specific aims: 1) Manage internal and external communication; 2) Advance scientific endeavors and ensure achieve- ment of specific milestones; 3) Effectively manage financial resources and ensure compliance. Thus, the Core will remove administrative and financial duties from the workload of VCORT scientists, allowing them to focus on research. The expected outcome is to have established and maintained a VCORT through which exceptional transla- tional science is conducted in a diverse, informed, and highly collaborative environment. This will have an im- portant positive impact on patients, caregivers, and the research community through progress toward under- standing and treating vitiligo, as well as establishing strong collaborations to expand the field of translational research in vitiligo and human autoimmunity.

全世界有超过7000万人患有白癜风，这是一种心理上毁灭性的自身免疫性疾病， 这种皮肤会导致毁容的白色斑点，并不成比例地影响那些皮肤较黑的人。这个，com- 结合缺乏FDA批准的白癜风治疗方法，为一些人创造了一个令人担忧的健康差距。 最脆弱的群体由于皮肤的可及性，白癜风提供了一个独特的机会- 为详细的，创新的转化研究提供了深入了解其发病机制和导致的研究， 改善治疗策略。此外，白癜风与自身免疫性白癜风具有遗传风险等位基因和其他机制。 更复杂和/或难以使用翻译工具研究的免疫疾病，因此提供了一种 这是一个无与伦比的模型，通过它可以了解人类自身免疫机制。 我们已经使用翻译多组学方法生成了初步数据，揭示了数千个新的 数据点标记了数百种新的信号通路，这些信号通路在维生素C缺乏症期间协调皮肤中的自身免疫， ligo。然而，仍然缺乏的是一种综合的、多学科的方法来收集这些新数据 从而全面了解白癜风皮损内的发病机制。因此，有一个关键的 需要建立一个协调的，合作的努力，揭示新的，高分辨率的发病机制的见解 白癜风和其他自身免疫性疾病，可以支持创新，先进的治疗策略。 我们将利用现有的数据、领先的多学科调查团队和尖端的研究工具 在白癜风研究翻译中心（VCORT）内完成这项任务。强有力的沟通， 协调、财政管理、教育和信息传播对成功实施这些战略至关重要。 这种多学科的努力。行政核心的总体目标是充当以下方面的接口： VCORT的参与者，以促进知识的产生和传播之间的合作投资， 老虎，更广泛的科学界和公众。我们将通过以下具体措施做到这一点： 目标：1）管理内部和外部沟通; 2）推进科学努力，确保实现- 3）有效管理财务资源，确保合规性。因此， 将从VCORT科学家的工作量中删除行政和财务职责，使他们能够专注于 做研究 预期的结果是建立和维持一个VCORT，通过它，特殊的transla- 国家科学是在一个多样化，知情和高度合作的环境中进行的。这将有一个IM- 对患者，护理人员和研究社区产生了重要的积极影响， 站在和治疗白癜风，以及建立强大的合作，以扩大翻译领域， 白癜风与人类自身免疫的研究。