UNC Center for AIDS Research Core I International

项目概要/摘要-国际核心（核心I） 该中心的国际核心促进翻译，临床，流行病学，行为和健康 我们的北卡罗来纳州的成员和国际调查人员之间的服务研究中心， 疫我们将FHI 360和RTI的科学家与海外的关键研究人群联系起来， 将国内科学家与北卡罗来纳州的合作和培训机会联系起来。核心提供 向在国际上开展工作的CFAR成员提供重要的行政和后勤支助服务， 注意早期阶段的研究人员和教师谁是新扩大他们的工作到全球设置。之间 核心I提供的最重要的服务是管理国际IRB关系， 通过一个专门的国际监管事务单位进行集中管理。这一关键部门管理着 研究伦理和监管提交的所有国际艾滋病毒研究活动，在北京。 国际核心还充当与艾滋病毒有关的国际研究培训活动的协调机构。 我们的CFAR共有10个国家卫生研究院的培训赠款，主要是艾滋病毒/艾滋病。在未来的资金 我们将加倍努力，通过定期召开会议， 他们的领导，共享关键资源，并协调实习生安置。为此，我们 提议新的培训联合主任，主要负责将受训人员与适当的 CFAR导师，并协助他们制定新的研究建议，我们的发展核心， 美国国立卫生研究院。 我们的核心的其他关键职能包括确保我们的CFAR的国际艾滋病毒/艾滋病研究符合 地方优先事项。这将通过建立一个新的内部咨询委员会来实现，该委员会的成员包括 我们工作的5个“重点国家”中的每一个。核心一的领导层还将确保当地 在我们工作的各个方面，支持向调查人员和思想领袖传播关键调查结果 在我们的国际站点，并促进南南研究能力交流。由于实验室能力 是如此重要的研究在国际环境中，我们的核心已经创建了一个实验室支持单位，根据我们的 马拉维的旗舰实验室。该实验室的主要人员可协助其他艾滋病毒研究中心， 新检测试剂盒的部署，质量保证程序的开发和监测， 监测访问和实验室操作问题的故障排除。 最后，核心一将继续通过积极参与正在进行的框架内财务报告促进外部合作 活动，并通过链接我们的会员与其他NIH赞助的网络，如ACTG，MTN， IMPAACT、HPTN和HVTN。

PROJECT SUMMARY/ ABSTRACT – INTERNATIONAL CORE (CORE I) The UNC CFAR International Core facilitates translational, clinical, epidemiological, behavioral, and health services research between our North Carolina-based members and international investigators at the center of the epidemic. We connect UNC, FHI360, and RTI scientists to critical research populations overseas and connect in-country scientists to collaborations and training opportunities in North Carolina. The Core provides critical administrative and logistical support services to CFAR members working internationally, with particular attention to early stage investigators and faculty who are newly expanding their work into a global setting. Among the most important of the services provided by Core I is the management of international IRB relationships, which is centralized through a dedicated international regulatory affairs unit. This critical unit manages all aspects of research ethics and regulatory submissions for all international HIV research activities at UNC. The International core also serves as a coordinating body for international HIV-related research training activities. Our CFAR has a total of 10 active NIH training grants with major HIV/AIDS components. In the coming funding cycle, we will redouble our efforts to enhance the collective impact of these programs through regular convening of their leadership, sharing key resources, and coordinating trainee placement. Toward this end, we are proposing a new Co-Director for Training who will be primarily responsible for connecting trainees to appropriate CFAR mentorship and assisting them in developing new research proposals to our developmental Core and to the NIH. Other key functions of our core include ensuring that our CFAR’s international HIV/AIDS research is in line with local priorities. This will be done through establishing a new internal advisory board comprising membership from each of the 5 “focus countries” in which we work. The Core I leadership will also ensure engagement of local investigators in all aspects of our work, support dissemination of key findings to investigators and thought leaders at our international sites, and facilitate south-to-south exchange of research capacity. Since laboratory capacity is so important to research in international settings, our core has created a laboratory support unit based at our flagship lab site in Malawi. Key personnel from this laboratory are available to assist other HIV research sites in the deployment of new assays, development and monitoring of quality assurance procedures, preparation for monitoring visits, and troubleshooting of lab operational problems. Finally, Core I will continue to promote external collaboration through active participation in ongoing intra-CFAR activities and through linking our membership with other NIH-sponsored networks, such as ACTG, MTN, IMPAACT, HPTN, and HVTN.