UNC Center for AIDS Research Core I International

北卡罗来纳大学艾滋病研究中心 I 国际

• 批准号: 10404034
• 负责人: JEFFREY Samuel Allen STRINGER
• 金额: $ 20.54万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404034
• 关键词: AIDS clinical trial group; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Affect; Africa; Africa South of the Sahara; Asia; Attention; Award; Biomedical Research; China; Clinical; Collaborations; Country; Creativeness; Developing Countries; Development; Educational workshop; Ensure; Epidemic; Epidemiology; Evaluation; Exercise; Faculty; Fostering; Funding; Grant; HIV; HIV Seroprevalence; HIV Vaccine Trials Network; Health Services Research; Health system; Institution; Institutional Review Boards; International; International Maternal Pediatric Adolescent AIDS Clinical Trials; Investments; Laboratories; Laboratory Personnel; Leadership; Link; Logistics; Malawi; Mentorship; Mission; Modeling; Monitor; North Carolina; Policies; Population; Preparation; Procedures; Regulatory Affairs; Research; Research Activity; Research Ethics; Research Personnel; Research Proposals; Research Training; Resource-limited setting; Resources; Role; Scientist; Seeds; Services; Site; South Africa; Standardization; Strategic Planning; Surveys; Training; Training Activity; Translational Research; United States National Institutes of Health; Universities; Vietnam; Visit; Work; Writing; Zambia; assay development; base; behavioral health; biobank; burden of illness; career development; global health; innovation; interest; member; next generation; outreach; programs; quality assurance; success; training opportunity

PROJECT SUMMARY/ ABSTRACT – INTERNATIONAL CORE (CORE I) The UNC CFAR International Core facilitates translational, clinical, epidemiological, behavioral, and health services research between our North Carolina-based members and international investigators at the center of the epidemic. We connect UNC, FHI360, and RTI scientists to critical research populations overseas and connect in-country scientists to collaborations and training opportunities in North Carolina. The Core provides critical administrative and logistical support services to CFAR members working internationally, with particular attention to early stage investigators and faculty who are newly expanding their work into a global setting. Among the most important of the services provided by Core I is the management of international IRB relationships, which is centralized through a dedicated international regulatory affairs unit. This critical unit manages all aspects of research ethics and regulatory submissions for all international HIV research activities at UNC. The International core also serves as a coordinating body for international HIV-related research training activities. Our CFAR has a total of 10 active NIH training grants with major HIV/AIDS components. In the coming funding cycle, we will redouble our efforts to enhance the collective impact of these programs through regular convening of their leadership, sharing key resources, and coordinating trainee placement. Toward this end, we are proposing a new Co-Director for Training who will be primarily responsible for connecting trainees to appropriate CFAR mentorship and assisting them in developing new research proposals to our developmental Core and to the NIH. Other key functions of our core include ensuring that our CFAR’s international HIV/AIDS research is in line with local priorities. This will be done through establishing a new internal advisory board comprising membership from each of the 5 “focus countries” in which we work. The Core I leadership will also ensure engagement of local investigators in all aspects of our work, support dissemination of key findings to investigators and thought leaders at our international sites, and facilitate south-to-south exchange of research capacity. Since laboratory capacity is so important to research in international settings, our core has created a laboratory support unit based at our flagship lab site in Malawi. Key personnel from this laboratory are available to assist other HIV research sites in the deployment of new assays, development and monitoring of quality assurance procedures, preparation for monitoring visits, and troubleshooting of lab operational problems. Finally, Core I will continue to promote external collaboration through active participation in ongoing intra-CFAR activities and through linking our membership with other NIH-sponsored networks, such as ACTG, MTN, IMPAACT, HPTN, and HVTN.

项目摘要/摘要--国际核心(核心一) 北卡罗来纳大学CFAR国际核心促进翻译、临床、流行病学、行为和健康 我们在北卡罗来纳州的成员和国际调查人员之间的服务研究 这场流行病。我们将北卡罗来纳大学、Fhi360和RTI的科学家与海外的关键研究群体联系起来， 将国内科学家与北卡罗来纳州的合作和培训机会联系起来。核心提供 向在国际上工作的CFAR成员提供关键的行政和后勤支助服务，特别是 关注早期研究人员和教职员工，他们正在将工作扩展到全球环境。其中 Core I提供的最重要的服务是管理国际IRB关系，这 是通过一个专门的国际监管事务单位集中管理的。这个关键单元管理着 北卡罗来纳大学所有国际艾滋病毒研究活动的研究道德和监管提交。 国际核心组织还作为国际艾滋病毒相关研究培训活动的协调机构。 我们的CFAR总共有10笔现役NIH培训赠款，其中包括艾滋病毒/艾滋病的主要组成部分。在即将到来的资金中 我们将加倍努力，通过定期召开会议，加强这些方案的集体影响。 他们的领导力，共享关键资源，协调实习生安置。为此，我们正在 提议一名新的培训联合主任，主要负责将受训人员与适当的 CFAR指导并协助他们为我们的发展核心制定新的研究建议 美国国立卫生研究院。 我们核心的其他关键职能包括确保我们的CFAR的国际艾滋病毒/艾滋病研究与 地方优先事项。为此，将成立一个新的内部咨询委员会，成员包括 我们工作的5个“焦点国家”中的每一个。第一核心领导层还将确保与当地 在我们工作的各个方面，支持将关键发现传播给调查人员和思想领袖 在我们的国际站点，并促进南南研究能力的交流。由于实验室容量 对于国际环境下的研究是如此重要，我们的核心创建了一个实验室支持单位，总部设在我们的 马拉维的旗舰实验室基地。该实验室的主要人员可以协助其他艾滋病毒研究地点 部署新的化验方法，开发和监测质量保证程序，准备 监督探访，并解决实验室操作问题。 最后，第一核心将继续通过积极参与正在进行的CFAR来促进外部合作 并通过将我们的成员与其他NIH赞助的网络，如ACTG，MTN， IMPAACT、HPTN和HVTN。