CAREER DEVELOPMENT AWARD IN PERINATAL HIV PREVENTION

描述(改编自申请人的描述)：本报告的目的 导师以患者为本的研究职业发展奖是为 妇产科讲师杰弗里·斯特林格博士 阿拉巴马大学伯明翰分校(UAB)妇科，有足够的 受保护的时间1)在理论上建立广泛的理解基础 和临床研究的实际方面；2)在实践中积累经验 在发展中国家进行方法学严谨的临床研究， 特别是在围产期艾滋病毒预防领域；以及3)进一步发展 他在决策分析、成本效益分析和产科方面的技能 结果研究。这些技能将以系统的方式获得，因为 在这份研究事业奖的申请中概述了。斯特林格博士将寻求 加州大学伯克利分校公共卫生理科硕士学位 流行病学和国际卫生，特别强调决策 分析、结果研究和临床试验设计。除了这一点， 在他的导师斯坦·弗蒙德博士的指导下，进行了正式的教学培训， 斯特林格博士将负责一项试点临床试验的所有方面 赞比亚卢萨卡围产期艾滋病毒预防战略，包括规划、 实施、实施和分析。这一经历将为您提供 具有宝贵的实践经验和现场专业知识的候选人 在发展中国家开展临床研究。此外，在 在他的合作导师罗伯特·戈登伯格博士的指导下，他将进行一项 亚临床型绒毛膜羊膜炎与 自发性早产和艾滋病毒垂直传播，具有特殊的 强调一些妊娠中期标志物测试的预测价值， 利用从一项大型随机临床试验中收集的样本。 这一经验将为应聘者提供许多方面的专业知识 重要的实验室技术、标本管理和复杂的统计学 分析。这一奖项的累积效应将使斯特林格博士 为了成功竞争NIH的个人研究经费，并最终 帮助提高妇女及其婴儿的健康和地位 发展中世界。

DESCRIPTION (Adapted from applicant's description): The purpose of this Mentored Patient-Oriented Research Career Development Award is to provide Dr. Jeffrey Stringer, Instructor in the Department of Obstetrics and Gynecology at the University of Alabama at Birmingham (UAB), with sufficient protected time to 1) develop a broad base of understanding in the theoretical and practical aspects of clinical research; 2) gain experience in the conduct of methodologically-rigorous clinical research in the developing world, particularly in the area of perinatal HIV prevention; and 3) further develop his skills in decision analysis, cost-effectiveness analysis, and obstetrical outcomes research. These skills will be obtained in a systematic fashion, as outlined in this research career award application. Dr. Stringer will seek the Master's of Science degree in Public Health (MSPH) from UAB's Department of Epidemiology and Intemational Health, with a special emphasis on decision analysis, outcomes research, and clinical trials design. In addition to this formal didactic training, under the direction of his mentor, Dr. Sten Vermund, Dr. Stringer will be responsible for all aspects of a pilot clinical trial of perinatal HIV prevention strategies in Lusaka, Zambia, including planning, implementation, conduct, and analysis. This experience will provide the candidate with valuable practical experience and field expertise in the conduct of clinical research in the developing world. Additionally, under the direction of his Co-mentor, Dr. Robert Goldenberg, he will undertake an investigation of the relationships among subclinical chorioamnionitis, spontaneous preterm birth, and vertical HIV transmission, with special emphasis on the predictive value of a number of mid-pregnancy marker tests, utilizing specimens collected ancillary to a large randomized clinical trial. This experience will provide the candidate with expertise in a number of important laboratory techniques, specimen management, and complex statistical analyses. The cumulative effect of this award will be to enable Dr. Stringer to compete successfully for individual investigator NIH funding and ultimately to help advance the health and status of women and their infants in the developing world.