Air Pollution Exposures in Early Life and Brain Development in Children

生命早期的空气污染暴露与儿童大脑发育

• 批准号: 10405564
• 负责人: SARAH F. BENKI-NUGENT
• 金额: $ 53.79万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10405564
• 关键词: 3 year old; Africa South of the Sahara; Age; Air Pollutants; Air Pollution; Ancillary Study; Animal Model; Aromatic Polycyclic Hydrocarbons; Attention Deficit Disorder; Attention deficit hyperactivity disorder; Award; Biological Assay; Biological Markers; Brain; Carbon Black; Characteristics; Child; Child Development; Child Health; Childhood; Clinical Trials; Cognition; Cognitive; Communication; Conceptions; Country; Data; Development; Educational workshop; Environmental Health; Environmental Risk Factor; Evaluation; Experimental Models; Exposure to; Faculty; Fostering; Foundations; Future; Goals; Government; Household; Household Air Pollution; Hybrids; Impulsive Behavior; Income; Industrialization; Industry; Infant; Informal Social Control; Institution; Intellectual functioning disability; Intervention; Kenya; Laboratories; Language; Life; Link; Longevity; Maternal and Child Health; Measurement; Measures; Methods; Modeling; Monitor; Mothers; Motor; Motor Skills; Neurotoxins; Outcome; Particulate; Particulate Matter; Performance; Pilot Projects; Policies; Policy Maker; Policy Making; Pregnancy; Private Sector; Process; Program Sustainability; Prospective Studies; Prospective cohort; Public Policy; Research; Resource-limited setting; Science; Scientist; Screening procedure; Source; Students; Technical Expertise; Third Pregnancy Trimester; Time; Tissues; Ultrafine; Universities; Washington; Work; air monitoring; ambient air pollution; autism spectrum disorder; base; biobank; biological specimen archives; cofactor; cognitive performance; cohort; cooking; design; early childhood; early life exposure; epidemiology study; executive function; experience; fine particles; follow-up; infancy; innovation; low income country; mortality; neurodevelopment; neurotoxic; neurotoxicity; novel; pollutant; postnatal; prenatal; programs; prospective; repetitive behavior; research to practice; skills; student mentoring; ultrafine particle; urinary

ABSTRACT It is increasingly clear that ambient and household sources of combustion derived air pollutants threaten healthy neurodevelopment based on research conducted in high income settings. Advances describe the neurotoxic potential of traffic-derived emissions, components such as polycyclic aromatic hydrocarbons (PAHs), and physical characteristics such as ultrafine particulate (UFP) in experimental models, mechanistic studies, and observational epidemiological studies of ADHD, autism, and cognitive performance. However, in low resourced settings such as sub-Saharan Africa (SSA) where exposure magnitudes are among the highest worldwide, data and capacity are lacking. We seek to extend a highly productive 30 plus year University of Washington – University of Nairobi maternal child health research partnership to incorporate capacity building and research focused on air pollution and child neurodevelopment in urban Kenya. We leverage a unique pre conception cohort and apply both biomarkers (urinary PAH metabolites) and mobile monitoring approaches to understand air pollution exposure across the early life continuum (pregnancy/infancy) as well as describe the impact of sources from ambient and household origin. Follow up to age 3 years will determine the relationship between early life air pollution exposure and child motor, cognitive, self-regulation, and executive function skills. The design and engagement reflects 2 pilot projects awarded in the past year which yielded practical experience and extensive discussions with environmental scientists and maternal child health experts in Nairobi. The project fills current gaps in child neurodevelopmental assessments as well as exposure science and laboratory methods to promote maternal child environmental health research in SSA. The project will advance lab capacity for neurotoxic biomarkers at two key institutions, will establish innovative methods for ambient air pollution measurement, will develop a unique pre conception cohort with a biospecimen archive and detailed neurodevelopmental outcome data – each foundational components of long-term, well-executed studies of air pollution exposure and brain development across the lifespan. Our overarching goal is to establish a sustained research to practice program that connects high quality, regionally relevant research to program and policy to reduce modifiable environmental risks to healthy child neurodevelopment.

抽象的 越来越明显的是，环境和家庭燃烧源产生的空气污染物威胁着健康 基于在高收入环境中进行的研究的神经发育。进展描述了潜在的神经毒性 交通产生的排放、多环芳烃 (PAH) 等成分以及物理 实验模型、机理研究和观察中的超细颗粒 (UFP) 等特征 ADHD、自闭症和认知表现的流行病学研究。然而，在资源匮乏的环境中，例如 撒哈拉以南非洲 (SSA) 的暴露强度是全球最高的，数据和容量 缺乏。 我们力求延续华盛顿大学-内罗毕大学母婴30多年的高产 健康研究伙伴关系将能力建设和重点研究空气污染和儿童问题纳入其中 肯尼亚城市的神经发育。我们利用独特的受孕前队列并应用这两种生物标志物 （尿液 PAH 代谢物）和移动监测方法，以了解整个地区的空气污染暴露情况 早期生命的连续体（怀孕/婴儿期）以及描述环境和家庭来源的影响 起源。 3岁以下的随访将确定生命早期空气污染暴露与儿童之间的关系 运动、认知、自我调节和执行功能技能。设计和参与体现了 2 个飞行员 去年授予的项目产生了实践经验并与各方进行了广泛讨论 内罗毕的环境科学家和妇幼健康专家。该项目填补了目前儿童领域的空白 神经发育评估以及暴露科学和实验室方法，以促进孕产妇 SSA 儿童环境健康研究。该项目将提高神经毒性生物标志物的实验室能力 两个关键机构将建立环境空气污染测量的创新方法，将开发 独特的孕前队列，具有生物样本档案和详细的神经发育结果数据 - 每个 关于空气污染暴露和大脑发育的长期、执行良好的研究的基础组成部分 贯穿整个生命周期。我们的首要目标是建立一个持续的研究与实践计划，将 高质量、与区域相关的计划和政策研究，以减少可改变的环境风险 健康的儿童神经发育。