The behavioral microstructure of a memory-guided food-caching behavior and its relationship to hippocampal replay

记忆引导的食物缓存行为的行为微观结构及其与海马重放的关系

• 批准号: 10406272
• 负责人: Selmaan Chettih
• 金额: $ 7.48万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10406272
• 关键词: 3-Dimensional; Affect; Animals; Behavior; Behavior monitoring; Behavioral; Behavioral Model; Behavioral Paradigm; Biological Models; Birds; Cells; Cognition; Computer Models; Data; Detection; Electrophysiology (science); Elements; Episodic memory; Event; Exhibits; Food; Future; Grain; Hippocampus (Brain); Individual; Laboratories; Link; Location; Measurement; Measures; Memory; Memory impairment; Movement; Nature; Neurons; Pattern; Positioning Attribute; Posture; Process; Retrieval; Rodent; Role; Route; Series; Site; Space Models; Structure; Techniques; Time; Training; Work; base; behavior measurement; deep learning; experience; experimental study; extracellular; flexibility; gaze; improved; indexing; insight; kinematics; memory consolidation; memory retrieval; nervous system disorder; neuromechanism; novel strategies; optogenetics; tool; way finding

Project Summary The hippocampus is a critical site for rapid memory formation and retrieval, with extensively documented functions representing spatial and navigational variables, yet less is known of the means by which it guides behavior. Bursts of hippocampal activity identified in many species as sharp-wave ripple (SWR) events are promising neural mechanisms to link hippocampal activity and behavioral function, since during SWRs hippocampus can represent positions the animal previously experienced, or will traverse in the near future. This proposal considers the food-caching behaviors of chickadees, who use a hippocampal-dependent, one- shot memory to guide cache retrieval. This behavior is exceptionally promising to link hippocampal activity to individual experiences, which has been a barrier to determining the nature of representations during SWR and their function in previous studies. These studies will develop a comprehensive account of how chickadee behavior is affected by cache site memory, determine whether SWRs are related to memory-specific components of caching behavior, and determine whether SWRs represent individual cache sites to assist later retrieval. I hypothesize that memory-guided behavior is distinguishable from random foraging. I will use video tracking to measure the behavioral microstructure of chickadee caching behavior, including postural and gaze time series, and develop quantitative models of behavioral motifs and their temporal structure. Using these tools to compare memory-guided and random foraging behaviors, I will develop decoders that indicate precisely how and when behavior appears memory-guided. I hypothesize that SWRs occur more often, and are more predictive of behavior, when behavior is memory- guided. I will use electrophysiology in freely moving chickadees during caching to relate SWRs to the microstructural analysis of behavior and decoding of behavioral strategy. I hypothesize that SWRs reactivate representations of previous, individual caching events, and that this reactivation improves subsequent retrieval for that individual site. Using electrophysiological recordings in caching birds, I will relate reactivations to the accuracy of retrieval behavior. Using online SWR detection and suppression, I will further determine if SWRs causally affect later retrieval behavior.

项目摘要 海马体是快速记忆形成和提取的关键部位， 表示空间和导航变量的函数，但对它引导的方式知之甚少 行为在许多物种中，海马活动的爆发被鉴定为尖波涟漪（SWR）事件， 有希望的神经机制，连接海马活动和行为功能，因为在SWR 海马体可以代表动物以前经历过的位置，或者在不久的将来将要经历的位置。 这项建议考虑了山雀的食物储藏行为，山雀使用依赖于营地的一种， 引导缓存检索的快照内存。这种行为非常有希望将海马活动与 个人的经验，这一直是一个障碍，以确定表征的性质， 他们在以前的研究中的作用。这些研究将全面了解山雀 行为受缓存站点内存的影响，确定SWR是否与特定于内存的 缓存行为的组成部分，并确定SWR是否代表各个缓存站点，以便稍后提供帮助 检索 我假设记忆引导的行为与随机觅食是有区别的。我会用视频追踪 测量山雀缓存行为的行为微观结构，包括姿势和凝视时间序列， 并建立行为动机及其时间结构的定量模型。使用这些工具来 比较记忆引导和随机觅食行为，我将开发解码器，精确地指示如何 当行为出现记忆引导。 我假设，当行为是记忆时，SWR发生得更频繁，更能预测行为- 引导。我将使用电生理学在自由移动的山雀在缓存有关的SWR的 行为的微观结构分析和行为策略的解码。 我假设SWR重新激活了以前的单个缓存事件的表示， 重新激活改善了随后对该单个位点的检索。使用电生理记录 在缓存鸟类时，我将把重新激活与检索行为的准确性联系起来。使用在线驻波比检测和 抑制，我将进一步确定是否SWR因果影响以后的检索行为。