CHANGE OF GRANTEE INSTITUTION K23 HL146890 A Systems Approach to Align ICU Care with Patient Treatment Goals
受资助机构变更 K23 HL146890 使 ICU 护理与患者治疗目标保持一致的系统方法
基本信息
- 批准号:10406185
- 负责人:
- 金额:$ 18.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-05-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAdultAwardBehaviorBehavior TherapyBypassCaringCessation of lifeChronicClinicalClinical TrialsCollaborationsCommunicationCommunication ToolsComplexConduct Clinical TrialsCritical CareCritical IllnessDecision MakingDependenceDevelopment PlansElderlyEngineeringEnvironmentExtramural ActivitiesFaceFailureFamilyFamily PhysiciansFoundationsFundingFutureGoalsHealthcareIncidenceIndividualIntensive Care UnitsInterventionK-Series Research Career ProgramsKnowledgeLeadLearningLifeLungMedicalMedicineMentored Patient-Oriented Research Career Development AwardMentorsMentorshipMethodsModelingMulticenter TrialsOperative Surgical ProceduresOrgan failureOutcomes ResearchOutcomes and Health Services ResearchPatient CarePatient PreferencesPatientsPersonsPhysiciansPrevalenceProceduresProcessPropertyQuality of lifeReportingResearchResearch InfrastructureResearch PersonnelResourcesRiskSchoolsSeriesSiteStructureStudy modelsSurgeonSyndromeSystemTestingTrainingUnited StatesUniversitiesWorkacceptability and feasibilitycareercareer developmentclinical practicedesignend of lifeend of life careend-of-life decision makingengineering designexperiencefeasibility testingfunctional independencehealth care deliveryimprovedinterestmedical schoolsnovelnovel strategiesolder patientpatient orientedpatient populationpilot testpreferenceprogramsshared decision makingsimulationskillssocialtherapy designtherapy developmenttooluser centered design
项目摘要
ABSTRACT
The support of this career development award will help Jacqueline M Kruser, MD MS become an independent
physician-investigator with the training and experience necessary to improve communication and treatment
decision making for patients with critical illness. Dr. Kruser will use this award to build on her existing
foundation in health services and outcomes research to achieve two career development goals: (1) Develop
expertise in the application of systems engineering principles and methods in healthcare, and (2) Gain
knowledge and experience in the conduct of clinical trials of complex behavioral interventions. These skills will
expand Dr. Kruser's research focus beyond individual-level interventions to address the complex, system-level
factors that influence treatment decision making and end-of-life care for patients with life-threatening illness,
specifically in chronic critical illness. Dr. Kruser will achieve these career objectives through a 5-year career
development plan that involves structured didactics, patient-oriented experiential research, and intensive
mentoring. Dr. Kruser's career development will be mentored by Jane L Holl MD MPH, a physician with
experience in applying systems engineering methods in healthcare, with over 20 years of sustained extramural
funding, and an outstanding record of mentorship. The co-mentors of this award are experts in clinical trials
and outcomes research in critical care (Richard G Wunderink, MD), and end-of-life decision making and
behavioral intervention development (Margaret Schwarze, MD MPP). Dr. Kruser's career development will be
supported by the exceptional institutional environment of Northwestern University, including the (1) Dedicated
resources from the Division of Pulmonary and Critical Care Medicine and Department of Medicine, (2) Strong
research infrastructure of the interprofessional Center for Healthcare Studies (directed by Dr. Holl), and (3)
Established, productive collaborations between the McCormick School of Engineering and the Feinberg School
of Medicine. Nearly 400,000 people in the US develop chronic critical illness each year, and most older adults
with this condition will not survive beyond one year. Studies suggest that many older adults with chronic critical
illness who are near the end of life receive unwanted care that does not reflect their goals, values, or
preferences, referred to as “goal-discordant” care. Thus, the overall research objective of this award is to apply
the tools of systems engineering to adapt an existing individual-level communication tool, “Best Case/Worst
Case,” to reduce goal-discordant care in older adults at risk for chronic critical illness. Specific Aim 1 will
identify the most impactful ICU system failures in communication and treatment decision-making through a
Failure Mode, Effects, and Criticality Analysis. Next, Specific Aim 2 will use user-centered design engineering
and simulation testing to adapt “Best Case/Worst Case” to the complex ICU system. Finally, Specific Aim 3 will
test the feasibility and acceptability of the novel intervention through a two-site, pilot clinical trial.
摘要
这个职业发展奖的支持将帮助Jacqueline M Kruser,MD MS成为一名独立的
医生-研究人员,具有改善沟通和治疗所需的培训和经验
危重病人的决策。Kruser博士将利用这一奖项在她现有的基础上
保健服务和成果研究基金会,以实现两个职业发展目标:(1)发展
在医疗保健中应用系统工程原理和方法的专业知识,以及(2)收获
在进行复杂行为干预的临床试验方面的知识和经验。这些技能将
将Kruser博士的研究重点从个人层面的干预扩展到复杂的系统层面
影响危及生命的疾病患者的治疗决策和临终关怀的因素
尤其是在慢性危重疾病中。Kruser博士将通过5年的职业生涯实现这些职业目标
发展计划,包括结构化教学、以患者为导向的体验式研究和强化
辅导。克鲁斯博士的职业发展将由简·L·霍尔医学博士指导,她是一名
在医疗保健中应用系统工程方法的经验,有20多年的持续校外工作经验
资金,以及杰出的导师记录。该奖项的共同导师是临床试验专家。
重症监护和结局研究(理查德·G·温德因克,医学博士),以及临终决策和
行为干预发展(玛格丽特·施瓦茨,医学硕士)。克鲁瑟博士的职业发展将是
由西北大学特殊的制度环境支持,包括(1)致力于
来自肺和重症监护医学司和医学部的资源,(2)强大
跨专业医疗研究中心的研究基础设施(由霍尔博士指导),以及(3)
麦考密克工程学院和范伯格学院之间建立的卓有成效的合作
医学部。在美国,每年有近40万人患上慢性危重疾病,大多数老年人
这种情况下将无法存活超过一年。研究表明,许多患有慢性危重病的老年人
生命接近尾声的疾病接受不必要的护理,这些护理不能反映他们的目标、价值观或
偏好,指的是“目标不协调”的关怀。因此,该奖项的总体研究目标是应用
系统工程的工具,以适应现有的个人级别的沟通工具,“最佳情况/最坏情况”
案例:“减少有慢性危重疾病风险的老年人的目标不协调的护理。具体目标1将
通过以下方式确定通信和治疗决策中影响最大的ICU系统故障
故障模式、影响和危害性分析。接下来,《特定目标2》将采用以用户为中心的设计工程
以及模拟测试,使最好/最坏情况适应复杂的ICU系统。最后,具体目标3将
通过两个地点的先导性临床试验,测试新干预措施的可行性和可接受性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Jacqueline Marie Kruser其他文献
Jacqueline Marie Kruser的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Jacqueline Marie Kruser', 18)}}的其他基金
Optimizing Time-Limited Trials of Mechanical Ventilation in Acute Respiratory Failure: A Mixed Methods Observational Study
优化急性呼吸衰竭机械通气的限时试验:混合方法观察研究
- 批准号:
10633823 - 财政年份:2023
- 资助金额:
$ 18.84万 - 项目类别:
CHANGE OF GRANTEE INSTITUTION K23 HL146890 A Systems Approach to Align ICU Care with Patient Treatment Goals
受资助机构变更 K23 HL146890 使 ICU 护理与患者治疗目标保持一致的系统方法
- 批准号:
10324027 - 财政年份:2020
- 资助金额:
$ 18.84万 - 项目类别:
CHANGE OF GRANTEE INSTITUTION K23 HL146890 A Systems Approach to Align ICU Care with Patient Treatment Goals
受资助机构变更 K23 HL146890 使 ICU 护理与患者治疗目标保持一致的系统方法
- 批准号:
10625915 - 财政年份:2020
- 资助金额:
$ 18.84万 - 项目类别:
A Systems Approach to Align ICU Care with Patient Treatment Goals
使 ICU 护理与患者治疗目标保持一致的系统方法
- 批准号:
9918968 - 财政年份:2019
- 资助金额:
$ 18.84万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 18.84万 - 项目类别:
Research Grant