An integrated theranostic system for breast cancer
乳腺癌综合治疗诊断系统
基本信息
- 批准号:10405593
- 负责人:
- 金额:$ 42.85万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-06-11 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AblationAddressAftercareAgeAnesthesia proceduresAnimalsBenignBloodBreastBreast Cancer ModelBreast Cancer PatientBreast Cancer TreatmentBreast conservationBypassCancer EtiologyCessation of lifeCicatrixClinicClinicalCoagulation ProcessDetectionDiagnosisDiagnosticDiseaseEarly treatmentElasticityElderly womanEngineeringEnsureFemale Breast CarcinomaFocused UltrasoundFocused Ultrasound TherapyGeneral AnesthesiaGenerationsHistologyHumanImageIn SituInterruptionIonsLesionLocal TherapyMagnetic Resonance ImagingMalignant - descriptorMalignant NeoplasmsMammary Gland ParenchymaMammary NeoplasmsMastectomyMechanicsMethodologyMethodsModelingMonitorMorbidity - disease rateMotionMusNonmetastaticNormal tissue morphologyOperative Surgical ProceduresOutpatientsPatientsPerformancePopulationProceduresRadiationRecoveryRiskRoleSafetySpecimenSpeedSurvival RateSystemTechniquesTechnologyTestingTherapeuticThermal Ablation TherapyThermometryTimeTranslationsWomanbasebreast imagingbreast surgerycancer diagnosisclinical translationcomparativecostcost efficientdiagnostic valuehigh riskimage guidedin vivomalignant breast neoplasmminimally invasivemortality riskpreservationreal time monitoringside effectskin damagestandard caresurgical risktheranosticstumortumor growthultrasoundyoung woman
项目摘要
Breast cancer is the most frequently diagnosed cancer (excluding skin cancer) in women, and
is the second leading cause of cancer death among women in the U.S. Currently, one woman
in seven will develop breast cancer in her lifetime. Surgical intervention is warranted in most
cases. However, as tumors are being detected at increasingly earlier stages, new methods for
less invasive and more focal treatments are warranted. In sharp contrast with its premise, the
translation of high-intensity focused ultrasound (HIFU) to the clinic has been comparatively
anemic due to the unreliable (B-mode-based) or extremely costly and slow (MRI-based)
monitoring techniques available. There has thus been an urgent need for a simple, cost-
efficient technology that can reliably and efficiently monitor HIFU treatment and thereby ensure
its clinical translation. In order to address both needs and maintain the low cost of HIFU while
preserving all its advantages, we have developed the radiation-force-based technique of
Harmonic Motion Imaging (HMI) that can be used seamlessly with HIFU for simultaneous
tumor targeting and generation and monitoring of ablation, namely HMI for Focused
Ultrasound (HMIgFUS). In the proposed study, we will integrate the HMIgFUS into a clinical
system that will facilitate translation of HMIFU for the focal, thermal treatment of breast tumors.
The underlying hypothesis is that HMIgFUS using parallel beamforming will be capable of
optimally monitoring HIFU ablation in a clinical setting where speed of application is key. The
team assembled encompasses ultrasound, breast imaging, breast surgery, mouse tumor
models and histopathological analysis. Our group has demonstrated that motion estimation
using parallel beamforming is feasible 1) at extremely high framerates (up to 5000 fps)
ensuring highest quality of motion estimation including 2) high precision displacements, 3)
coherent compounding for SNR increase, 4) 2D capability as well as 5) real-time
implementation. Such a reliable monitoring technique could prove pivotal in rendering an
entirely noninvasive treatment accessible to a wide population of breast cancer patients for the
first time by propelling it into fast and reliable outpatient procedure for the focal treatment of
benign or small, non-metastatic breast cancer, thus minimizing mortality and risk.
乳腺癌是女性最常被诊断出的癌症(不包括皮肤癌),
是美国女性癌症死亡的第二大原因。
七分之一的人会在有生之年患上乳腺癌。手术干预是必要的,
例然而,随着肿瘤在越来越早的阶段被检测到,
需要更少的侵入性和更集中的治疗。与其前提形成鲜明对比的是,
高强度聚焦超声(HIFU)在临床上的应用
由于不可靠(基于B模式)或极其昂贵和缓慢(基于MRI)导致贫血
现有的监测技术。因此,迫切需要一个简单的,成本-
能够可靠有效地监测HIFU治疗,从而确保
临床翻译为了满足这两种需求并保持HIFU的低成本,
在保留其所有优点的基础上,我们开发了基于辐射力的技术,
谐波运动成像(HMI),可与HIFU无缝配合使用,
肿瘤靶向以及消融的生成和监测,即用于聚焦的HMI
超声(HMIgFUS)。在拟议的研究中,我们将把HMIgFUS整合到临床上,
该系统将促进用于乳腺肿瘤的局灶性热治疗的HIFU的平移。
基本假设是使用并行波束成形的HMIgFUS将能够
在应用速度是关键的临床环境中最佳地监测HIFU消融。的
组建的团队包括超声、乳腺成像、乳腺手术、小鼠肿瘤
模型和组织病理学分析。我们的团队已经证明运动估计
使用并行波束成形是可行的1)在极高的帧速率(高达5000 fps)
确保最高质量的运动估计,包括2)高精度位移,3)
相干复合以增加SNR,4)2D能力以及5)实时
实施.这种可靠的监测技术可以证明是关键的,
乳腺癌患者的广泛人群可以获得完全无创治疗,
首次将其推进到快速可靠的门诊程序中,用于重点治疗
良性或小的非转移性乳腺癌,从而最大限度地降低死亡率和风险。
项目成果
期刊论文数量(14)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Imaging of Single Transducer-Harmonic Motion Imaging-Derived Displacements at Several Oscillation Frequencies Simultaneously.
- DOI:10.1109/tmi.2022.3178897
- 发表时间:2022-11
- 期刊:
- 影响因子:10.6
- 作者:
- 通讯作者:
Technical Note: In vivo Young's modulus mapping of pancreatic ductal adenocarcinoma during HIFU ablation using harmonic motion elastography (HME).
技术说明:使用谐波运动弹性成像 (HME) 对 HIFU 消融过程中的胰腺导管腺癌进行体内杨氏模量测绘。
- DOI:10.1002/mp.13170
- 发表时间:2018
- 期刊:
- 影响因子:3.8
- 作者:Nabavizadeh,Alireza;Payen,Thomas;Saharkhiz,Niloufar;McGarry,Matthew;Olive,KennethP;Konofagou,ElisaE
- 通讯作者:Konofagou,ElisaE
Harmonic motion imaging of human breast masses: an in vivo clinical feasibility.
人体乳腺肿块的谐波运动成像:体内临床可行性。
- DOI:10.1038/s41598-020-71960-5
- 发表时间:2020
- 期刊:
- 影响因子:4.6
- 作者:Saharkhiz,Niloufar;Ha,Richard;Taback,Bret;Li,XiaoyueJudy;Weber,Rachel;Nabavizadeh,Alireza;Lee,StephenA;Hibshoosh,Hanina;Gatti,Vittorio;Kamimura,HermesAS;Konofagou,ElisaE
- 通讯作者:Konofagou,ElisaE
An analytical model of full-field displacement and strain induced by amplitude-modulated focused ultrasound in harmonic motion imaging.
- DOI:10.1088/1361-6560/abddd1
- 发表时间:2021-04-06
- 期刊:
- 影响因子:3.5
- 作者:McGarry MDJ;Campo A;Payen T;Han Y;Konofagou EE
- 通讯作者:Konofagou EE
Harmonic Motion Imaging-Guided Focused Ultrasound Ablation: Comparison of Three Focused Ultrasound Interference Filtering Methods.
- DOI:10.1016/j.ultrasmedbio.2023.09.012
- 发表时间:2023-10
- 期刊:
- 影响因子:2.9
- 作者:X. Li;M. Hossain;Stephen Alexander Lee;Niloufar Saharkhiz;E. Konofagou
- 通讯作者:X. Li;M. Hossain;Stephen Alexander Lee;Niloufar Saharkhiz;E. Konofagou
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Elisa E. Konofagou其他文献
Microbubble ultrasound maps hidden signs of heart disease
微泡超声可映射出心脏病的隐匿迹象
- DOI:
10.1038/d41586-024-01194-2 - 发表时间:
2024-05-06 - 期刊:
- 影响因子:48.500
- 作者:
Elisa E. Konofagou - 通讯作者:
Elisa E. Konofagou
DOSSIER IMAGERIE ACOUSTIQUE ET OPTIQUE DES MILIEUX BIOLOGIQUES OPTICAL AND ACOUSTICAL IMAGING OF BIOLOGICAL MEDIA Elastography
DOSIER IMAGERIE ACUSTIQUE ET OPTIQUE DE MILIEUX BIOLOGIQUES 生物介质的光学和声学成像 弹性成像
- DOI:
- 发表时间:
2001 - 期刊:
- 影响因子:0
- 作者:
Jonathan Ophir;F. Kallel;Tomy Varghese;Elisa E. Konofagou;S. Alam;Thomas A. Krouskop;Brian S. Garra;R. Righetti - 通讯作者:
R. Righetti
Characterization of microbubble cavitation in theranostic ultrasound-mediated blood-brain barrier opening for gene delivery
治疗超声介导血脑屏障开放用于基因递送中微泡空化的表征
- DOI:
10.1016/j.jconrel.2025.113986 - 发表时间:
2025-09-10 - 期刊:
- 影响因子:11.500
- 作者:
Fotios N. Tsitsos;Alec J. Batts;Daniella A. Jimenez;Craig A. Macsemchuk;Chunqi Li;Robin Ji;Sua Bae;Gillian L. Ciaccio;Angeliki Theodorou;Rashell K. Ramirez;Samantha L. Gorman;Chloe L. Lugg;Elisa E. Konofagou - 通讯作者:
Elisa E. Konofagou
Amplitude-Modulation Frequency Optimization for Enhancing Harmonic Motion Imaging Performance of Breast Tumors in the Clinic
- DOI:
10.1016/j.ultrasmedbio.2024.09.021 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:
- 作者:
Yangpei Liu;Md Murad Hossain;Xiaoyue Judy Li;Elisa E. Konofagou - 通讯作者:
Elisa E. Konofagou
Elastography : Imagerie acoustique et optique des milieux biologiques
弹性成像:声学图像和生物环境光学
- DOI:
- 发表时间:
2001 - 期刊:
- 影响因子:0
- 作者:
Jonathan Ophir;F. Kallel;Tomy Varghese;Elisa E. Konofagou;S. Alam;Thomas A. Krouskop;Brian S. Garra;R. Righetti - 通讯作者:
R. Righetti
Elisa E. Konofagou的其他文献
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{{ truncateString('Elisa E. Konofagou', 18)}}的其他基金
Assessment of ultrasound-facilitated neurotherapeutics in Alzheimer's disease
超声辅助神经疗法治疗阿尔茨海默病的评估
- 批准号:
10901036 - 财政年份:2023
- 资助金额:
$ 42.85万 - 项目类别:
Mechanical characterization of carotid plaques for stroke risk assessment
用于中风风险评估的颈动脉斑块的机械特征
- 批准号:
10735746 - 财政年份:2023
- 资助金额:
$ 42.85万 - 项目类别:
A theranostic system for ultrasound-facilitated blood-brain barrier opening
超声促进血脑屏障开放的治疗诊断系统
- 批准号:
10541109 - 财政年份:2020
- 资助金额:
$ 42.85万 - 项目类别:
A theranostic system for ultrasound-facilitated blood-brain barrier opening
超声促进血脑屏障开放的治疗诊断系统
- 批准号:
10318649 - 财政年份:2020
- 资助金额:
$ 42.85万 - 项目类别:
A theranostic system for ultrasound-facilitated blood-brain barrier opening
超声促进血脑屏障开放的治疗诊断系统
- 批准号:
9917485 - 财政年份:2020
- 资助金额:
$ 42.85万 - 项目类别:
Mechanistic Monitoring of Ultrasound Neuromodulation
超声神经调节的机械监测
- 批准号:
10087928 - 财政年份:2019
- 资助金额:
$ 42.85万 - 项目类别:
Mechanistic Monitoring of Ultrasound Neuromodulation
超声神经调节的机械监测
- 批准号:
9765827 - 财政年份:2019
- 资助金额:
$ 42.85万 - 项目类别:
Mechanistic Monitoring of Ultrasound Neuromodulation
超声神经调节的机械监测
- 批准号:
10376177 - 财政年份:2019
- 资助金额:
$ 42.85万 - 项目类别:
Mechanistic Monitoring of Ultrasound Neuromodulation
超声神经调节的机械监测
- 批准号:
9906227 - 财政年份:2019
- 资助金额:
$ 42.85万 - 项目类别:
An integrated theranostic system for breast cancer
乳腺癌综合治疗诊断系统
- 批准号:
9975111 - 财政年份:2018
- 资助金额:
$ 42.85万 - 项目类别:
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