Mechanistic Monitoring of Ultrasound Neuromodulation

超声神经调节的机械监测

基本信息

  • 批准号:
    10087928
  • 负责人:
  • 金额:
    $ 64.74万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-04-04 至 2022-12-31
  • 项目状态:
    已结题

项目摘要

Central Nervous System diseases affect several millions of patients in the U.S. Current drug treatments are often associated with side-effects such as dyskinesia, confusion, dizziness, insomnia, depression, and pathological gambling among others. Neuromodulation can be achieved either with noninvasive techniques that are depth limited or invasive procedures that can go to large depths. Over the past few years, transcranial focused ultrasound (FUS) has been shown capable of both stimulating and suppressing brain activity in vivo. Ultrasound has several advantages over the aforementioned technologies for deep brain stimulation as it can penetrate the brain over several centimeters through the intact scalp and skull. Given its entirely noninvasive and nonionizing nature, the technique has been shown to be translatable to human brain studies with deep penetration (of several centimeters) without requiring introduction of electrodes or optic fibers inside the brain. In the proposed study, we will aim to harness from the technical expertise available by the group of investigators so as to develop monitoring of the underlying physical and physiological mechanisms in vivo and in real time and simultaneously sync technologies that will allow translation to humans. The three physical mechanisms to be investigated are radiation force, cavitation and perfusion, all of which can be monitored in conjunction with FUS modulation by the PI’s group. Therefore, the underlying hypothesis of the proposed studies is that if these underlying mechanisms, or the combination thereof, can be monitored during application, FUS can be more targeted and better monitored to improve on its reproducibility and optimization. To this end, we have assembled a highly complementary, multi-disciplinary team from ultrasound engineering, anatomical and functional imaging, neuroscience, neurology, neuroengineering and neurosurgery. The methodologies proposed require breakthroughs in current FUS methodologies used in order to selectively focus (on the order of a few millimeters) and steer across both shallow and deep-seated regions (on the order of several centimeters in depth) as well as informing on the physical (i.e., radiation force or cavitation - mechanical tissue effects exerted by ultrasound on the brain) and physiological (i.e., neuronal effects as a result of the aforementioned mechanical tissue effects) mechanism in real time. This study is thus aimed to optimize targeting and efficacy of FUS neuromodulation by mapping the physical mechanism so as to better explore noninvasive modulation of motor and motivation responses in humans for the first time for the ultimate treatment of conditions ranging from movement to psychiatric disorders.
在美国,中枢神经系统疾病影响着数百万患者

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Elisa E. Konofagou其他文献

Microbubble ultrasound maps hidden signs of heart disease
微泡超声可映射出心脏病的隐匿迹象
  • DOI:
    10.1038/d41586-024-01194-2
  • 发表时间:
    2024-05-06
  • 期刊:
  • 影响因子:
    48.500
  • 作者:
    Elisa E. Konofagou
  • 通讯作者:
    Elisa E. Konofagou
DOSSIER IMAGERIE ACOUSTIQUE ET OPTIQUE DES MILIEUX BIOLOGIQUES OPTICAL AND ACOUSTICAL IMAGING OF BIOLOGICAL MEDIA Elastography
DOSIER IMAGERIE ACUSTIQUE ET OPTIQUE DE MILIEUX BIOLOGIQUES 生物介质的光学和声学成像 弹性成像
  • DOI:
  • 发表时间:
    2001
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jonathan Ophir;F. Kallel;Tomy Varghese;Elisa E. Konofagou;S. Alam;Thomas A. Krouskop;Brian S. Garra;R. Righetti
  • 通讯作者:
    R. Righetti
Characterization of microbubble cavitation in theranostic ultrasound-mediated blood-brain barrier opening for gene delivery
治疗超声介导血脑屏障开放用于基因递送中微泡空化的表征
  • DOI:
    10.1016/j.jconrel.2025.113986
  • 发表时间:
    2025-09-10
  • 期刊:
  • 影响因子:
    11.500
  • 作者:
    Fotios N. Tsitsos;Alec J. Batts;Daniella A. Jimenez;Craig A. Macsemchuk;Chunqi Li;Robin Ji;Sua Bae;Gillian L. Ciaccio;Angeliki Theodorou;Rashell K. Ramirez;Samantha L. Gorman;Chloe L. Lugg;Elisa E. Konofagou
  • 通讯作者:
    Elisa E. Konofagou
Amplitude-Modulation Frequency Optimization for Enhancing Harmonic Motion Imaging Performance of Breast Tumors in the Clinic
  • DOI:
    10.1016/j.ultrasmedbio.2024.09.021
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    Yangpei Liu;Md Murad Hossain;Xiaoyue Judy Li;Elisa E. Konofagou
  • 通讯作者:
    Elisa E. Konofagou
Elastography : Imagerie acoustique et optique des milieux biologiques
弹性成像:声学图像和生物环境光学
  • DOI:
  • 发表时间:
    2001
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Jonathan Ophir;F. Kallel;Tomy Varghese;Elisa E. Konofagou;S. Alam;Thomas A. Krouskop;Brian S. Garra;R. Righetti
  • 通讯作者:
    R. Righetti

Elisa E. Konofagou的其他文献

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{{ truncateString('Elisa E. Konofagou', 18)}}的其他基金

Assessment of ultrasound-facilitated neurotherapeutics in Alzheimer's disease
超声辅助神经疗法治疗阿尔茨海默病的评估
  • 批准号:
    10901036
  • 财政年份:
    2023
  • 资助金额:
    $ 64.74万
  • 项目类别:
Mechanical characterization of carotid plaques for stroke risk assessment
用于中风风险评估的颈动脉斑块的机械特征
  • 批准号:
    10735746
  • 财政年份:
    2023
  • 资助金额:
    $ 64.74万
  • 项目类别:
A theranostic system for ultrasound-facilitated blood-brain barrier opening
超声促进血脑屏障开放的治疗诊断系统
  • 批准号:
    10541109
  • 财政年份:
    2020
  • 资助金额:
    $ 64.74万
  • 项目类别:
A theranostic system for ultrasound-facilitated blood-brain barrier opening
超声促进血脑屏障开放的治疗诊断系统
  • 批准号:
    10318649
  • 财政年份:
    2020
  • 资助金额:
    $ 64.74万
  • 项目类别:
A theranostic system for ultrasound-facilitated blood-brain barrier opening
超声促进血脑屏障开放的治疗诊断系统
  • 批准号:
    9917485
  • 财政年份:
    2020
  • 资助金额:
    $ 64.74万
  • 项目类别:
Mechanistic Monitoring of Ultrasound Neuromodulation
超声神经调节的机械监测
  • 批准号:
    9765827
  • 财政年份:
    2019
  • 资助金额:
    $ 64.74万
  • 项目类别:
Mechanistic Monitoring of Ultrasound Neuromodulation
超声神经调节的机械监测
  • 批准号:
    10376177
  • 财政年份:
    2019
  • 资助金额:
    $ 64.74万
  • 项目类别:
Mechanistic Monitoring of Ultrasound Neuromodulation
超声神经调节的机械监测
  • 批准号:
    9906227
  • 财政年份:
    2019
  • 资助金额:
    $ 64.74万
  • 项目类别:
An integrated theranostic system for breast cancer
乳腺癌综合治疗诊断系统
  • 批准号:
    9975111
  • 财政年份:
    2018
  • 资助金额:
    $ 64.74万
  • 项目类别:
An integrated theranostic system for breast cancer
乳腺癌综合治疗诊断系统
  • 批准号:
    10405593
  • 财政年份:
    2018
  • 资助金额:
    $ 64.74万
  • 项目类别:

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