Improving Survival in Oral Cancer by Disruption of Tumor Progression

通过破坏肿瘤进展来提高口腔癌的生存率

• 批准号: 10405550
• 负责人: Nisha J D'Silva
• 金额: $ 100.13万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-14 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10405550
• 关键词: Address; Development; Foundations; Head and Neck Cancer; Knowledge; Link; Molecular; Pathway interactions; Patients; Radiation; Recurrence; Resistance; Resistance development; Risk; Work; base; cancer cell; epithelial to mesenchymal transition; improved; malignant mouth neoplasm; novel; novel strategies; treatment strategy; tumor; tumor progression

ABSTRACT/ PROJECT SUMMARY Invasion is required for development and spread of head and neck cancer (HNC) but unfortunately there are no strategies that effectively target invasion. This knowledge gap is due to limited progress in identifying and understanding the underlying mechanisms that control invasion. While progress has been made in establishing that epithelial to mesenchymal transition in HNC cells allows them to spread and become resistant to treatment, critical mechanistic links are unknown. It is also unclear which tumors will spread and become resistant to treatment. Given the continued poor survival of patients with HNC, this project will address the following questions: 1) what are the mechanisms that encourage HNC to spread; 2) how is HNC protected from radiation and who is at risk for developing resistance; and 3) how does HNC recur. This work will provide the foundation for novel mechanism-based treatment strategies to improve the survival of patients with HNC.

摘要/项目摘要 头颈癌 (HNC) 的发展和扩散需要侵袭，但不幸的是， 没有有效针对入侵的策略。这种知识差距是由于在识别和识别方面进展有限。 了解控制入侵的潜在机制。虽然在建立 HNC 细胞中的上皮细胞到间质细胞的转变使它们能够扩散并产生耐药性 治疗中，关键的机制环节尚不清楚。目前还不清楚哪些肿瘤会扩散并成为 对治疗有抵抗力。鉴于 HNC 患者的生存率持续不佳，该项目将解决 以下问题：1）鼓励HNC传播的机制是什么？ 2）HNC如何受到保护 免受辐射以及有产生耐药性的风险的人； 3) HNC 如何复发。这项工作将提供 为提高 HNC 患者生存率的新型基于机制的治疗策略奠定了基础。