Improving Survival in Oral Cancer by Disruption of Tumor Progression
Improving Survival in Oral Cancer by Disruption of Tumor Progression
批准号:
10631930
负责人:
Nisha J D'Silva
金额:
$101.38万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
未结题
起止时间:
2017-09-14 至 2025-06-30
关键词:
DevelopmentFoundationsHead and Neck CancerInvadedKnowledgeLinkMolecularPathway interactionsPatient SelectionPatientsRadiation ProtectionRecurrenceRecurrent Malignant NeoplasmResistanceResistance developmentRiskWorkcancer cellcancer recurrenceepithelial to mesenchymal transitionimprovedmalignant mouth neoplasmnovelnovel strategiestreatment strategytumortumor progression
中文摘要
摘要/项目摘要
侵袭是头颈癌(HNC)发展和扩散所必需的,但不幸的是有
没有有效针对入侵的战略。造成这一知识差距的原因是在确定和
了解控制入侵的潜在机制。虽然在建立
HNC细胞上皮细胞向间充质细胞的转变使它们能够扩散并对
治疗,关键的机械环节是未知的。目前也不清楚哪些肿瘤会扩散并成为
对治疗有抗药性。鉴于HNC患者的存活率持续较低,该项目将解决
以下问题:1)鼓励HNC传播的机制是什么;2)HNC是如何保护的
以及谁有可能产生耐药性;以及3)HNC是如何复发的。这项工作将提供
为新的基于机制的治疗策略改善HNC患者的生存奠定了基础。
英文摘要
ABSTRACT/ PROJECT SUMMARY
Invasion is required for development and spread of head and neck cancer (HNC) but unfortunately there are
no strategies that effectively target invasion. This knowledge gap is due to limited progress in identifying and
understanding the underlying mechanisms that control invasion. While progress has been made in establishing
that epithelial to mesenchymal transition in HNC cells allows them to spread and become resistant to
treatment, critical mechanistic links are unknown. It is also unclear which tumors will spread and become
resistant to treatment. Given the continued poor survival of patients with HNC, this project will address the
following questions: 1) what are the mechanisms that encourage HNC to spread; 2) how is HNC protected
from radiation and who is at risk for developing resistance; and 3) how does HNC recur. This work will provide
the foundation for novel mechanism-based treatment strategies to improve the survival of patients with HNC.
期刊论文(9)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1007/s13402-021-00631-y
发表时间:
2022-04
期刊:
CELLULAR ONCOLOGY
影响因子:
6.6
作者:
[de Medeiros, Marcell Costa, Liu, Min, Banerjee, Rajat, Bellile, Emily, D'Silva, Nisha J., Rossa Jr, Carlos]
通讯作者:
Rossa Jr, Carlos
DOI:
10.1177/0022034519877388
发表时间:
2019-11-01
期刊:
Advances in dental research
影响因子:
--
作者:
[D'Silva, N J, Gutkind, J S]
通讯作者:
Gutkind, J S
DOI:
10.1096/fba.2021-00046
发表时间:
2021-10
期刊:
FASEB bioAdvances
影响因子:
2.7
作者:
[Schmitd LB, Perez-Pacheco C, D'Silva NJ]
通讯作者:
D'Silva NJ
Downstream effects of HPV integration on survival/metastasis in oropharyngeal cancer
-
批准号:10660945
-
项目类别:
-
资助金额:$57.51万
-
财政年份:2020
-
负责人:Nisha J D'Silva
-
依托单位:
Downstream effects of HPV integration on survival/metastasis in oropharyngeal cancer
-
批准号:10204988
-
项目类别:
-
资助金额:$58.41万
-
财政年份:2020
-
负责人:Nisha J D'Silva
-
依托单位:
Downstream effects of HPV integration on survival/metastasis in oropharyngeal cancer
-
批准号:10066438
-
项目类别:
-
资助金额:$57.55万
-
财政年份:2020
-
负责人:Nisha J D'Silva
-
依托单位:
Downstream effects of HPV integration on survival/metastasis in oropharyngeal cancer
-
批准号:10438782
-
项目类别:
-
资助金额:$58.46万
-
财政年份:2020
-
负责人:Nisha J D'Silva
-
依托单位:
Improving Survival in Oral Cancer by Disruption of Tumor Progression
-
批准号:10405550
-
项目类别:
-
资助金额:$100.13万
-
财政年份:2017
-
负责人:Nisha J D'Silva
-
依托单位:
Impact of nerves on cancer initiating cells and tumor progression
-
批准号:8871714
-
项目类别:
-
资助金额:$19.38万
-
财政年份:2014
-
负责人:Nisha J D'Silva
-
依托单位:
Impact of nerves on cancer initiating cells and tumor progression
-
批准号:8722135
-
项目类别:
-
资助金额:$23.33万
-
财政年份:2014
-
负责人:Nisha J D'Silva
-
依托单位:
Role of EZH2 in Invasion and Migration in the Oral Mucosa
-
批准号:8743202
-
项目类别:
-
资助金额:$34.99万
-
财政年份:2013
-
负责人:Nisha J D'Silva
-
依托单位:
Role of EZH2 in Invasion and Migration in the Oral Mucosa
-
批准号:8576552
-
项目类别:
-
资助金额:$34.99万
-
财政年份:2013
-
负责人:Nisha J D'Silva
-
依托单位:
Role of EZH2 in Invasion and Migration in the Oral Mucosa
-
批准号:8893946
-
项目类别:
-
资助金额:$34.99万
-
财政年份:2013
-
负责人:Nisha J D'Silva
-
依托单位:
Biomarkers in Head and Neck Cancer Progression
-
批准号:7807128
-
项目类别:
-
资助金额:$9.45万
-
财政年份:2009
-
负责人:Nisha J D'Silva
-
依托单位:
Biomarkers in Head and Neck Cancer Progression
-
批准号:8432362
-
项目类别:
-
资助金额:$9.45万
-
财政年份:2009
-
负责人:Nisha J D'Silva
-
依托单位:
Biomarkers in Head and Neck Cancer Progression
-
批准号:8054173
-
项目类别:
-
资助金额:$9.45万
-
财政年份:2009
-
负责人:Nisha J D'Silva
-
依托单位:
Biomarkers in Head and Neck Cancer Progression
-
批准号:8234862
-
项目类别:
-
资助金额:$9.45万
-
财政年份:2009
-
负责人:Nisha J D'Silva
-
依托单位:
Biomarkers in Head and Neck Cancer Progression
-
批准号:7570766
-
项目类别:
-
资助金额:$9.45万
-
财政年份:2009
-
负责人:Nisha J D'Silva
-
依托单位:
Characterization of the Immunomic Profile of Head and Neck Cancer
-
批准号:7617672
-
项目类别:
-
资助金额:$19.0万
-
财政年份:2008
-
负责人:Nisha J D'Silva
-
依托单位:
Characterization of the Immunomic Profile of Head and Neck Cancer
-
批准号:7470452
-
项目类别:
-
资助金额:$22.8万
-
财政年份:2008
-
负责人:Nisha J D'Silva
-
依托单位:
Role of Rap1 in cadherin and integrin mediated cross-talk in oral keratinocytes
-
批准号:7302787
-
项目类别:
-
资助金额:$34.2万
-
财政年份:2007
-
负责人:Nisha J D'Silva
-
依托单位:
Role of Rap1 in cadherin and integrin mediated cross-talk in oral keratinocytes
-
批准号:7477789
-
项目类别:
-
资助金额:$33.82万
-
财政年份:2007
-
负责人:Nisha J D'Silva
-
依托单位:
Role of Rap1 in cadherin and integrin mediated cross-talk in oral keratinocytes
-
批准号:7628566
-
项目类别:
-
资助金额:$33.82万
-
财政年份:2007
-
负责人:Nisha J D'Silva
-
依托单位:
海外基金