Brain Plasticity and Clinical Consequences of Adult-Onset Asymmetric Hearing Loss

成人发病的不对称听力损失的大脑可塑性和临床后果

• 批准号: 10412442
• 负责人: STEVEN WAN CHEUNG
• 金额: $ 68.52万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10412442
• 关键词: Acoustic Neuroma; Address; Adult; Aftercare; Auditory; Binaural; Brain; Brain imaging; Clinical; Clinical assessments; Data; Diagnostic; Diffusion Magnetic Resonance Imaging; Ear; Ear Neoplasms; Environment; Functional Magnetic Resonance Imaging; Goals; Hearing; Hearing problem; Impairment; Knowledge; Location; Loudness; Magnetoencephalography; Neuraxis; Numeric Rating Scale; Observational Study; Occupational Noise; Organizational Change; Otosclerosis; Outcome; Outcome Study; Participant; Patients; Perception; Performance; Peripheral; Prevalence; Psychoacoustics; Research; Research Design; Rest; Risk; Severities; Side; Source; Stapedectomies; Stimulus; Structure; Techniques; Testing; Tinnitus; asymmetric hearing loss; base; cohort; deafness; hearing preservation; improved; indexing; innovation; multimodality; neural correlate; neuroimaging; normal hearing; sound; speech recognition; tool

PROJECT SUMMARY Permanent sensorineural asymmetric hearing loss (AHL) disrupts extraction of interaural information for binaural processing. Using a cutoff of at least 15 dB interaural difference as definition of AHL, prevalence estimates vary widely, from 1% to 50%. Among cohorts with occupational noise exposure, AHL prevalence ranges from 15%- 49%. Critical clinical consequences include difficulty with sound target identification in noisy environments and degradation of spatial hearing. Beyond those impairments, the aidable poorer ear in AHL is at risk for accelerated decline and often burdened by tinnitus. There is a wide gap in our understanding of the relationship between central nervous system changes along the continuum of AHL magnitudes, audiological and psychoacoustical outcomes, and tinnitus perception. Closing this knowledge gap would be the first step to advance diagnostic tools and inspire innovative treatments for AHL. Informed by anchoring neuroimaging and audiological data from normal hearing and single-sided deafness, the most extreme form of AHL, we propose to close this knowledge gap. A comprehensive study on the clinical consequences of AHL should address hearing performance under adverse conditions, spatial hearing, and tinnitus outcomes, and their central neural correlates. We propose a longitudinal within-subject neuroimaging features and clinical assessments study of AHL before and after treatment by amplification. We will use resting-state magnetoencephalographic imaging (RS-MEGI) and functional magnetic resonance imaging (RS-fMRI), task-based MEGI, and diffusion MRI to examine temporal, functional and structural features, and audiological and psychoacoustical tests to evaluate hearing performance and tinnitus outcomes. This observational study will collect data from participants who will be treated by routine amplification with individualized tinnitus sound therapies, as required, for AHL. We will evaluate test-retest reliability of neuroimaging features, and assess neuroimaging features, hearing performance, and tinnitus outcomes at baseline and at months 3, 6 and 12 following treatment. The specific aims of this research are to examine: 1) AHL clinical outcomes, 2) AHL auditory interhemispheric temporal organization using MEGI, and 3) AHL whole brain functional and structural neuroimaging features using resting-state MEGI and fMRI (functional), task-based MEGI (functional), and diffusion MRI (structural).

项目摘要 永久性感音神经性非对称性听力损失（阿勒）干扰双耳听觉系统的耳间信息提取 处理.使用至少15 dB的耳间差异作为阿勒的定义，患病率估计值各不相同 从1%到50%。在职业性噪声暴露人群中，阿勒患病率范围为15%- 百分之四十九严重的临床后果包括在嘈杂的环境中难以识别声音目标， 空间听觉退化。除了这些损伤，阿勒中的听力较差的耳朵有风险， 加速下降，并经常由耳鸣负担。我们对这种关系的理解有很大的差距 中枢神经系统之间的变化沿着连续的阿勒幅度，听力和 心理声学结果和耳鸣感知。缩小这一知识差距将是第一步， 先进的诊断工具和启发创新的治疗阿勒。通过锚定神经成像和 从正常听力和单侧耳聋（阿勒的最极端形式）的听力学数据中，我们建议 填补这一知识空白。 对阿勒临床后果的全面研究应解决不良反应下的听力表现， 条件，空间听力和耳鸣结果，以及它们的中枢神经相关性。我们提出了一个纵向的 阿勒治疗前后受试者内神经影像学特征和临床评估研究 放大我们将使用静息态脑磁图成像（RS-MEGI）和功能性磁共振成像（FMRI）。 共振成像（RS-fMRI），基于任务的MEGI和扩散MRI检查颞，功能和 结构特征，听力学和心理声学测试，以评估听力性能和耳鸣 结果。这项观察性研究将从将接受常规扩增治疗的参与者中收集数据 根据需要，为阿勒提供个性化的耳鸣声音治疗。我们将评估的重测信度 神经影像学特征，并评估神经影像学特征，听力表现和耳鸣结果， 基线和治疗后第3、6和12个月。本研究的具体目的是：1） 阿勒临床结局，2）使用MEGI的阿勒听觉半球间颞叶组织，3）阿勒整体 使用静息态MEGI和fMRI（功能性）的脑功能和结构神经成像特征，基于任务 MEGI（功能）和弥散MRI（结构）。

项目成果

Unification of sparse Bayesian learning algorithms for electromagnetic brain imaging with the majorization minimization framework.

• DOI: 10.1016/j.neuroimage.2021.118309
• 发表时间: 2021-10-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Hashemi A;Cai C;Kutyniok G;Müller KR;Nagarajan SS;Haufe S
• 通讯作者: Haufe S

Clinical Validation of the Champagne Algorithm for Evoked Response Source Localization in Magnetoencephalography.

• DOI: 10.1007/s10548-021-00850-4
• 发表时间: 2022-01
• 期刊: Brain topography
• 影响因子: 2.7
• 作者: Bhutada AS;Cai C;Mizuiri D;Findlay A;Chen J;Tay A;Kirsch HE;Nagarajan SS
• 通讯作者: Nagarajan SS

Emergence of canonical functional networks from the structural connectome.

• DOI: 10.1016/j.neuroimage.2021.118190
• 发表时间: 2021-08-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Xie X;Cai C;Damasceno PF;Nagarajan SS;Raj A
• 通讯作者: Raj A

Spectral graph theory of brain oscillations.

脑振荡的谱图理论。

• DOI: 10.1002/hbm.24991
• 发表时间: 2020
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Raj,Ashish;Cai,Chang;Xie,Xihe;Palacios,Eva;Owen,Julia;Mukherjee,Pratik;Nagarajan,Srikantan
• 通讯作者: Nagarajan,Srikantan