Optimized Multi-Metabolite Edited MRS at 3T

3T 时优化的多代谢物编辑 MRS

• 批准号: 10410779
• 负责人: Mark Mikkelsen
• 金额: $ 8.32万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-18 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10410779
• 关键词: Accounting; Adult; Algorithmic Software; Algorithms; Anaerobic Bacteria; Antioxidants; Area; Aspartate; Award; Behavior; Biochemical; Biometry; Brain; Chemicals; Clinical; Cognition; Computer software; Data; Detection; Development; Environment; Evolution; Foundations; Frequencies; Future; Glutamates; Glutathione; Health; Human; Imaging Techniques; Institutes; K-Series Research Career Programs; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant neoplasm of brain; Mathematics; Measurement; Measures; Mechanics; Mental disorders; Mentors; Methodology; Methods; Modernization; N-acetylaspartylglutamate; National Institute of Mental Health; Neurotransmitters; Pathway interactions; Phase; Physics; Physiologic pulse; Process; Psychology; Quantum Mechanics; Reproducibility; Research; Research Personnel; Research Project Grants; Resolution; Resources; Scanning; Scheme; Scientist; Signal Transduction; Spectrum Analysis; System; Techniques; Technology; Testing; Time; Training; United States National Institutes of Health; Update; Variant; Work; ascorbate; base; career; clinical examination; cohort; cost; density; design; gamma-Aminobutyric Acid; improved; in vivo; nervous system disorder; neuroimaging; neuropathology; new technology; novel; novel strategies; quantum; reconstruction; simulation; skills; statistics

PROJECT SUMMARY Magnetic resonance spectroscopy (MRS) can noninvasively measure the concentration of endogenous metabolites in the body and brain. Lower-concentration metabolites have weaker MR signals and therefore are more difficult to detect. Edited MRS simplifies the MR spectrum so that these weaker signals can be more easily quantified. However, usually only a single metabolite is edited, leading to multiple scans and longer examination times when targeting multiple low-concentration metabolites. This project involves the development and implementation of a highly optimized multiplexed editing technique, termed sLASER-HERCULES, for the simultaneous detection of up to 8 low-concentration brain metabolites in a single scan. The reproducibility of this approach will be rigorously assessed in vivo in a cohort of adult subjects. Additionally, software algorithms based on spatially resolved density-matrix simulations and advanced statistics will be developed for optimizing the acquisition parameters of this MRS technique to improve the reliable measurement of specific groups of editable metabolites detectable by sLASER-HERCULES. The technologies generated from this project will improve the efficiency of edited MRS and its applicability to clinical MR exams and will ultimately allow multiple hypotheses to be tested from biochemical measurements collected in a single scan. The candidate will undertake tuition and training in MR physics, MRS acquisition methodology, and pulse programming to successfully implement the sLASER-HERCULES sequence. The training and research proposed in this project will be undertaken in a highly supportive institutional environment, with extensive resources available for research and professional support. The candidate will have access to state-of-the-art MR facilities and will be mentored by world leaders in MRS and MRI. The long-term career objective of the candidate is to establish himself as an independent early stage investigator with a complete repertoire of skills in MRS methodology and applications.

项目总结