Optimized Multi-Metabolite Edited MRS at 3T

3T 时优化的多代谢物编辑 MRS

• 批准号: 10410779
• 负责人: Mark Mikkelsen
• 金额: $ 8.32万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-18 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10410779
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PROJECT SUMMARY Magnetic resonance spectroscopy (MRS) can noninvasively measure the concentration of endogenous metabolites in the body and brain. Lower-concentration metabolites have weaker MR signals and therefore are more difficult to detect. Edited MRS simplifies the MR spectrum so that these weaker signals can be more easily quantified. However, usually only a single metabolite is edited, leading to multiple scans and longer examination times when targeting multiple low-concentration metabolites. This project involves the development and implementation of a highly optimized multiplexed editing technique, termed sLASER-HERCULES, for the simultaneous detection of up to 8 low-concentration brain metabolites in a single scan. The reproducibility of this approach will be rigorously assessed in vivo in a cohort of adult subjects. Additionally, software algorithms based on spatially resolved density-matrix simulations and advanced statistics will be developed for optimizing the acquisition parameters of this MRS technique to improve the reliable measurement of specific groups of editable metabolites detectable by sLASER-HERCULES. The technologies generated from this project will improve the efficiency of edited MRS and its applicability to clinical MR exams and will ultimately allow multiple hypotheses to be tested from biochemical measurements collected in a single scan. The candidate will undertake tuition and training in MR physics, MRS acquisition methodology, and pulse programming to successfully implement the sLASER-HERCULES sequence. The training and research proposed in this project will be undertaken in a highly supportive institutional environment, with extensive resources available for research and professional support. The candidate will have access to state-of-the-art MR facilities and will be mentored by world leaders in MRS and MRI. The long-term career objective of the candidate is to establish himself as an independent early stage investigator with a complete repertoire of skills in MRS methodology and applications.

项目摘要 磁共振波谱（MRS）可以无创地测量内源性 代谢物在身体和大脑中。较低浓度的代谢物具有较弱的MR信号，因此 更难被发现。编辑的MRS简化了MR频谱，使得这些较弱的信号可以更容易地被 量化。然而，通常只编辑单个代谢物，导致多次扫描和更长的检查 当靶向多种低浓度代谢物时，该项目涉及开发和 实施高度优化的多重编辑技术，称为sLASER-HERCULES，用于 在一次扫描中同时检测多达8种低浓度脑代谢物。这种重复性 方法将在成年受试者队列中进行严格的体内评估。此外，基于软件算法的 空间分辨密度矩阵模拟和先进的统计将开发优化 这种MRS技术的采集参数，以提高特定组的可编辑的 可通过sLASER-HERCULES检测的代谢物。该项目产生的技术将改善 编辑MRS的效率及其对临床MR检查的适用性，最终将允许多种假设 从单次扫描收集的生化测量中进行测试。候选人将承担学费， MR物理、MRS采集方法和脉冲编程培训，以成功实施 sLASER-HERCULES序列。本项目中提出的培训和研究将在一个高度 有利的体制环境，有广泛的资源可供研究和专业支助。 候选人将有机会获得最先进的MR设施，并将在MRS世界领导人的指导下 和MRI。候选人的长期职业目标是建立自己作为一个独立的早期阶段 在MRS方法和应用方面拥有完整技能的调查员。