Multi-modal magnetic resonance imaging in progressive supranuclear palsy (PSP)

进行性核上性麻痹 (PSP) 的多模态磁共振成像

• 批准号: 10408127
• 负责人: Alexander Y. Pantelyat
• 金额: $ 19万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408127
• 关键词: Affect; Alzheimer' s disease related dementia; Bilateral; Biological Markers; Brain imaging; Caring; Characteristics; Clinical; Clinical Trials; Cognition; Cognition Disorders; Contralateral; Corpus striatum structure; Data; Deterioration; Development; Diagnosis; Differential Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; Dorsal; Educational workshop; Functional Magnetic Resonance Imaging; Goals; Grant; Heterogeneity; Image; Image Analysis; Imaging Techniques; Impairment; Inferior; Language; Language Disorders; Leadership; Longevity; Magnetic Resonance Imaging; Manuscripts; Measures; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Methods; Midbrain structure; Movement Disorders; Neurodegenerative Disorders; Neurologist; Outcome; Outcome Measure; Outcomes Research; Parietal Lobe; Patients; Preparation; Progressive Supranuclear Palsy; Public Health; Quality of life; Research; Research Design; Research Personnel; Research Project Grants; Research Proposals; Rest; Side; Speech; Statistical Data Interpretation; Syndrome; Therapeutic Intervention; Time; Training; Work; Writing; base; career; clinical diagnostics; corticobasal syndrome; diagnostic accuracy; diagnostic criteria; executive function; experience; experimental study; frontal lobe; frontotemporal degeneration; gray matter; imaging study; improved; innovation; meetings; motor control; multimodality; network dysfunction; neuroimaging; neuroimaging marker; programs; response; responsible research conduct; skills; treatment response

PROJECT SUMMARY/ABSTRACT This is an application for a Mentored Patient-Oriented Research Career Development Award (K23). The goal of the proposed project is to provide the candidate with skills necessary to develop an independent research program dedicated to the development of neuroimaging biomarkers in Progressive Supranuclear Palsy (PSP) and other Alzheimer disease-related dementias. To facilitate this long-term career goal the candidate will: 1) identify multimodal (volumetric, structural and functional connectivity) magnetic resonance imaging (MRI) differences among 3 PSP subtypes (PSP-Richardson syndrome (PSP-RS), PSP-Speech/Language Disorder (PSP-SL), and PSP-Corticobasal syndrome (PSP-CBS)) as delineated in the recently revised PSP diagnostic criteria, and 2) examine the associations between these imaging features with cross-sectional characteristics and 1-year clinical change. The candidate proposes a comprehensive training plan, combining formal coursework, meetings and tutorials overseen by his mentors, participation in applied training experiences, and involvement in seminars and workshops. Specific training goals include: 1) training in neuroimaging methods and image analysis; 2) advanced training in experimental study design and statistical analysis; 3) advanced training in clinical trials methodology; 4) training in manuscript preparation, grant writing and leadership capability; and 5) continued training in the responsible conduct of research. The training plan will be implemented in coordination with a research project based on preliminary data collected by the applicant. The primary hypotheses to be examined are: 1) In PSP-RS, there will be greater structural and functional connectivity disruptions in bilateral dorsal midbrain and frontostriatal gray matter compared with other PSP subtypes, and significant associations between baseline bilateral diffusion tensor imaging (DTI) dorsal midbrain/resting state-fMRI (rs-fMRI) frontostriatal connectivity and executive function; 2) In PSP-SL, there will be greater structural and functional connectivity disruptions in the dominant inferior frontal cortex and its subcortical speech network connections, and significant associations between baseline DTI and rs-fMRI measures in the dominant inferior frontal lobe and language function; and 3) In PSP-CBS, there will be greater structural and functional connectivity disruptions in the parietal lobe-dorsolateral striatum network contralateral to the most affected side, and significant associations between baseline DTI and rs-fMRI measures in the parietal lobe-dorsolateral striatum and praxis. Results from this research will be used to develop a R01 research proposal that will facilitate the candidate’s transition to an independent researcher.

项目总结/文摘

项目成果

Association of Progressive Supranuclear Palsy Rating Scale with Progressive Supranuclear Palsy Quality of Life Scale.

• DOI: 10.1159/000514519
• 发表时间: 2020
• 期刊: Neuro-degenerative diseases
• 作者: Pantelyat A;Higginbotham L;Rosenthal L;Lanham D;Nesspor V;AlSalihi M;Bang J;Wang J;Albert M
• 通讯作者: Albert M